**************************************************************************************************************************************************************************************************** MOTIFSIM - Motif Similarity Detection Tool Version 2.1 **************************************************************************************************************************************************************************************************** INPUT **************************************************************************************************************************************************************************************************** Input Parameters Number of files: 2 Number of top significant motifs: 10 Number of best matches: 10 Similarity cutoff: >= 0.75 Matching motif database: UniProbe Mus Musculus Phylogenetic tree: Yes Combined similar motifs: Yes Output file type: All Output file format: All Input files and motif counts File name Count of motifs Dataset # MEME-ChIP_DM721.txt 11 1 PScanChIP_DM721.txt 37 2 **************************************************************************************************************************************************************************************************** RESULTS **************************************************************************************************************************************************************************************************** *************************************************************** Combined Motifs for Top Best Match Motif ID 1 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 1 EWSR1-FLI1 Reverse Complement Reverse Complement MTTCCK CCTTCCTTCCTTCCTTCC TCCTTCCTTCCCTTCCTC Direction: Backward Position #: 12 Overlap #: 6 Alignment: -MTTCCK----------- CCTTCCTTCCTTCCTTCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Original Motif Original Motif TCCTTCCTTCCCTTCCTC BAACGTCCGC TMMCKTCCKCTCCTTCCT Direction: Backward Position #: 1 Overlap #: 10 Alignment: TCCTTCCTTCCCTTCCTC --------BAACGTCCGC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_5-13 Combined Motif Original Motif Reverse Complement TMMCKTCCKCTCCTTCCT BTHCCCCTYB TMMHKTCCSCTCCTTCCT Direction: Forward Position #: 4 Overlap #: 10 Alignment: TMMCKTCCKCTCCTTCCT ---BTHCCCCTYB----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NFKB1 Original Motif Original Motif TMMHKTCCSCTCCTTCCT GGGGRTTCCCC GKSVVTTCCCCTCCTTCCT Direction: Forward Position #: 2 Overlap #: 10 Alignment: -TMMHKTCCSCTCCTTCCT GGGGRTTCCCC-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Reverse Complement GKSVVTTCCCCTCCTTCCT TGRCCTKTGHCCKAB TGDCCDTTSCCCTMCTTCCT Direction: Forward Position #: 2 Overlap #: 14 Alignment: -GKSVVTTCCCCTCCTTCCT TGRCCTKTGHCCKAB----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 7 Combined Motif Reverse Complement Reverse Complement AGGAAGRAGGGSAADGGHCA GGGGMGGG GHCAGGGGMGGGAGGAAGRA Direction: Backward Position #: 5 Overlap #: 8 Alignment: AGGAAGRAGGGSAADGGHCA --------GGGGMGGG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 2 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 2 Motif 11 Reverse Complement Reverse Complement TGTRT TGTGTGTGTGTKTG TGTGTGTGTGTKTG Direction: Forward Position #: 5 Overlap #: 5 Alignment: ----TGTRT----- TGTGTGTGTGTKTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 9 Reverse Complement Original Motif CAYACACACACACA CACACAVRCACACA CACACACACACACA Direction: Forward Position #: 1 Overlap #: 14 Alignment: CAYACACACACACA CACACAVRCACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement TGTGTGTGTGTGTG BGRRRGRGGRTGRTTYGGGG TGTGKGKGDGKGTGRTTYGGGG Direction: Forward Position #: 3 Overlap #: 12 Alignment: TGTGTGTGTGTGTG-------- --BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Reverse Complement Reverse Complement CCCCMAAMCACYCDCRCRCACA AAAAAAACAAARRA CCCCAAAAMAMYMAMRVACACA Direction: Forward Position #: 5 Overlap #: 14 Alignment: CCCCMAAMCACYCDCRCRCACA ----AAAAAAACAAARRA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Original Motif CCCCAAAAMAMYMAMRVACACA HWDAGHACRHHVTGTHCCHVMV CCCCAAAAVAACAHMVHRYACMHVMV Direction: Forward Position #: 5 Overlap #: 18 Alignment: CCCCAAAAMAMYMAMRVACACA---- ----HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Reverse Complement VRVDYGTMMHBRHTGTTVTTTTGGGG TGRCCTKTGHCCKAB TGRCCTKTVCCBDHBGTTVTTTTGGGG Direction: Forward Position #: 2 Overlap #: 14 Alignment: -VRVDYGTMMHBRHTGTTVTTTTGGGG TGRCCTKTGHCCKAB------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ArntAhr Combined Motif Reverse Complement Reverse Complement CCCCAAAAVAACVHHBGGVAYAGGKCA CACGCM CCMCRMAAVAACVHHBGGVAYAGGKCA Direction: Forward Position #: 2 Overlap #: 6 Alignment: CCCCAAAAVAACVHHBGGVAYAGGKCA -CACGCM-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement CCMCRMAAVAACVHHBGGVAYAGGKCA MSGKKRCGCWDCABTGBBCD CCMCRMVRBDACVCHDVRVWBHBVKCA Direction: Forward Position #: 6 Overlap #: 20 Alignment: CCMCRMAAVAACVHHBGGVAYAGGKCA -----MSGKKRCGCWDCABTGBBCD-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Original Motif TGRVBHBWVKVDHGVGTDBMBRMGYGG TGAMCTTTGMMCYT TGAMCTTTGVVVHKVGTDBMBRMGYGG Direction: Forward Position #: 1 Overlap #: 14 Alignment: TGRVBHBWVKVDHGVGTDBMBRMGYGG TGAMCTTTGMMCYT------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Original Motif Reverse Complement TGAMCTTTGVVVHKVGTDBMBRMGYGG MGCCCCCTGMCA HGHCCCCTGVCAHKVGTDBMBRMGYGG Direction: Forward Position #: 1 Overlap #: 12 Alignment: TGAMCTTTGVVVHKVGTDBMBRMGYGG MGCCCCCTGMCA--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 3 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 3 EWSR1-FLI1 Original Motif Original Motif AGSCWGG GGAAGGAAGGAAGGAAGG AAGGAGGMAGGGGAAGGA Direction: Backward Position #: 5 Overlap #: 7 Alignment: -------AGSCWGG---- GGAAGGAAGGAAGGAAGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Reverse Complement Reverse Complement TCCTTCCCCTRCCTCCTT MGCCCCCTGMCA TCCKYCCCCTRCCWCCTT Direction: Forward Position #: 3 Overlap #: 12 Alignment: TCCTTCCCCTRCCTCCTT --MGCCCCCTGMCA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Tcfcp2l1 Reverse Complement Reverse Complement AAGGWGGMAGGGGMRGGA CKGGDTBDMMCTGG CWRGGWGVMASGGGMRGGA Direction: Forward Position #: 2 Overlap #: 13 Alignment: -AAGGWGGMAGGGGMRGGA CKGGDTBDMMCTGG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif CWRGGWGVMASGGGMRGGA TTCAGCACCATGGACAGCKCC TTCAGCACCATGGACAGSKHBVMASGGGMRGGA Direction: Forward Position #: 15 Overlap #: 7 Alignment: --------------CWRGGWGVMASGGGMRGGA TTCAGCACCATGGACAGCKCC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Reverse Complement Original Motif TCCKYCCCSTYVBDYSCTGTCCATGGTGCTGAA CCCCKCCCCC YCCBBCCCCYYVBDYSCTGTCCATGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 10 Alignment: TCCKYCCCSTYVBDYSCTGTCCATGGTGCTGAA CCCCKCCCCC----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif YCCBBCCCCYYVBDYSCTGTCCATGGTGCTGAA BBVGCCBVGGCCTV YCCBBCCBSCYBVGSCCTGTCCATGGTGCTGAA Direction: Forward Position #: 6 Overlap #: 14 Alignment: YCCBBCCCCYYVBDYSCTGTCCATGGTGCTGAA -----BBVGCCBVGGCCTV-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 7 Original Motif Original Motif YCCBBCCBSCYBVGSCCTGTCCATGGTGCTGAA CCCRCCCC CCCVCCCCSCYBVGSCCTGTCCATGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 8 Alignment: YCCBBCCBSCYBVGSCCTGTCCATGGTGCTGAA CCCRCCCC------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif TTCAGCACCATGGACAGGSCVBKGSGGGGVGGG VDBHMAGGTCACCCTGACCY TTCAGVACCHHGGWCAGSCYGVSBBGGGGVGGG Direction: Forward Position #: 6 Overlap #: 20 Alignment: TTCAGCACCATGGACAGGSCVBKGSGGGGVGGG -----VDBHMAGGTCACCCTGACCY-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RORA_1 Combined Motif Original Motif Original Motif TTCAGVACCHHGGWCAGSCYGVSBBGGGGVGGG AWVDAGGTCA TTCAGVAHCHAGGTCAGSCYGVSBBGGGGVGGG Direction: Forward Position #: 7 Overlap #: 10 Alignment: TTCAGVACCHHGGWCAGSCYGVSBBGGGGVGGG ------AWVDAGGTCA----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Reverse Complement CCCVCCCCBBSBCMGSCTGACCTHGDTVCTGAA GCCYCMCCCD BCCBCCCCCDSBCMGSCTGACCTHGDTVCTGAA Direction: Forward Position #: 1 Overlap #: 10 Alignment: CCCVCCCCBBSBCMGSCTGACCTHGDTVCTGAA GCCYCMCCCD----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 4 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 4 NR1H2RXRA Reverse Complement Original Motif KCAGAG AAAGGTCAAAGGTCAAC AAAGGTCARAGGTCAAC Direction: Forward Position #: 6 Overlap #: 6 Alignment: -----KCAGAG------ AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Original Motif AAAGGTCARAGGTCAAC BTRGGDCARAGGKCA VDRGGKCARAGGTCAAC Direction: Forward Position #: 1 Overlap #: 15 Alignment: AAAGGTCARAGGTCAAC BTRGGDCARAGGKCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Original Motif Reverse Complement VDRGGKCARAGGTCAAC AKGYYCAAAGRTCA VVRGBKCAAAGGTCAAC Direction: Forward Position #: 2 Overlap #: 14 Alignment: VDRGGKCARAGGTCAAC -AKGYYCAAAGRTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif VVRGBKCAAAGGTCAAC RGGBCAAAGKYCA VVGGBYMAARGBYMAAC Direction: Forward Position #: 2 Overlap #: 13 Alignment: VVRGBKCAAAGGTCAAC -RGGBCAAAGKYCA--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MIZF Combined Motif Original Motif Reverse Complement VVGGBYMAARGBYMAAC GCGGACGTTV VVGGBYMAARGGCSRACGTTV Direction: Forward Position #: 12 Overlap #: 6 Alignment: VVGGBYMAARGBYMAAC---- -----------GCGGACGTTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Original Motif Original Motif VVGGBYMAARGGCSRACGTTV TGYCAGGGGGCR VVKGBCARRGGGCRRACGTTV Direction: Forward Position #: 3 Overlap #: 12 Alignment: VVGGBYMAARGGCSRACGTTV --TGYCAGGGGGCR------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Original Motif Reverse Complement VVKGBCARRGGGCRRACGTTV GGGGGYGGGG VRKGKYDGGGGGCRRACGTTV Direction: Forward Position #: 1 Overlap #: 10 Alignment: VVKGBCARRGGGCRRACGTTV GGGGGYGGGG----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Reverse Complement Original Motif BAACGTMMGCCCCCHKYCYMV TTCAGCACCATGGACAGCKCC BAACKTCAGCMCCMHGGMCAGCKCC Direction: Forward Position #: 5 Overlap #: 17 Alignment: BAACGTMMGCCCCCHKYCYMV---- ----TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 8 Combined Motif Original Motif Reverse Complement BAACKTCAGCMCCMHGGMCAGCKCC TCCCAG CKCCKCCCAGBAACKTCAGCMCCMH Direction: Backward Position #: 5 Overlap #: 6 Alignment: BAACKTCAGCMCCMHGGMCAGCKCC ---------------TCCCAG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 5 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 5 RREB1 Reverse Complement Reverse Complement RARAT BGRRRGRGGRTGRTTYGGGG GRTTYGGGGRRGATBGRRRG Direction: Backward Position #: 10 Overlap #: 5 Alignment: ------RARAT--------- BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Reverse Complement Reverse Complement CMMMCBATCKMCCCCMAAMC AAAAAAACAAARRA CMMMCBATCKMCCCCAAAAMAACAAARRA Direction: Forward Position #: 16 Overlap #: 5 Alignment: CMMMCBATCKMCCCCMAAMC--------- ---------------AAAAAAACAAARRA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR4A2 Combined Motif Original Motif Original Motif CMMMCBATCKMCCCCAAAAMAACAAARRA AAGGTCAC CMMMCDAKVTCMCCCAAAAMAACAAARRA Direction: Forward Position #: 6 Overlap #: 8 Alignment: CMMMCBATCKMCCCCAAAAMAACAAARRA -----AAGGTCAC---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Original Motif Reverse Complement CMMMCDAKVTCMCCCAAAAMAACAAARRA AKGYYCAAAGRTCA AKSHHCMAAGRTCACCCAAAAMAACAAARRA Direction: Forward Position #: 3 Overlap #: 12 Alignment: --CMMMCDAKVTCMCCCAAAAMAACAAARRA AKGYYCAAAGRTCA----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MIZF Combined Motif Original Motif Original Motif AKSHHCMAAGRTCACCCAAAAMAACAAARRA BAACGTCCGC AKSHHCHAASGTCMSCCAAAAMAACAAARRA Direction: Forward Position #: 7 Overlap #: 10 Alignment: AKSHHCMAAGRTCACCCAAAAMAACAAARRA ------BAACGTCCGC--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Original Motif Original Motif AKSHHCHAASGTCMSCCAAAAMAACAAARRA AAAGGTCAAAGGTCAAC AARGBTCAAAGGTCAVCCAAAAMAACAAARRA Direction: Forward Position #: 2 Overlap #: 16 Alignment: -AKSHHCHAASGTCMSCCAAAAMAACAAARRA AAAGGTCAAAGGTCAAC--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Original Motif AARGBTCAAAGGTCAVCCAAAAMAACAAARRA BTRGGDCARAGGKCA VDRGGBCAAAGGTCAVCCAAAAMAACAAARRA Direction: Forward Position #: 1 Overlap #: 15 Alignment: AARGBTCAAAGGTCAVCCAAAAMAACAAARRA BTRGGDCARAGGKCA----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif VDRGGBCAAAGGTCAVCCAAAAMAACAAARRA TTCAGCACCATGGACAGCKCC THCAGSACMAWGGWCAGCCMMAAMAACAAARRA Direction: Forward Position #: 2 Overlap #: 20 Alignment: -VDRGGBCAAAGGTCAVCCAAAAMAACAAARRA TTCAGCACCATGGACAGCKCC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Original Motif THCAGSACMAWGGWCAGCCMMAAMAACAAARRA RGKTCABVVRGAGGTCA RGKTVRBVSMRAGGTCAGCCMMAAMAACAAARRA Direction: Forward Position #: 2 Overlap #: 16 Alignment: -THCAGSACMAWGGWCAGCCMMAAMAACAAARRA RGKTCABVVRGAGGTCA----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RORA_1 Combined Motif Original Motif Original Motif RGKTVRBVSMRAGGTCAGCCMMAAMAACAAARRA AWVDAGGTCA RGKTVRBDHVDAGGTCAGCCMMAAMAACAAARRA Direction: Forward Position #: 8 Overlap #: 10 Alignment: RGKTVRBVSMRAGGTCAGCCMMAAMAACAAARRA -------AWVDAGGTCA----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 6 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 6 REST Original Motif Original Motif CMGCRGC TTCAGCACCATGGACAGCKCC ATGGACAGCKCCCAGCASCTT Direction: Backward Position #: 13 Overlap #: 7 Alignment: --CMGCRGC------------ TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Original Motif Reverse Complement ATGGACAGCKCCCAGCASCTT GCGGACGTTV DYGGACRKHDCCCAGCASCTT Direction: Forward Position #: 1 Overlap #: 10 Alignment: ATGGACAGCKCCCAGCASCTT GCGGACGTTV----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Original Motif Reverse Complement DYGGACRKHDCCCAGCASCTT VAGGCCBBGGCVBB VMGGMCDKBVCCCVGCASCTT Direction: Forward Position #: 1 Overlap #: 14 Alignment: DYGGACRKHDCCCAGCASCTT VAGGCCBBGGCVBB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TFAP2A Combined Motif Original Motif Original Motif VMGGMCDKBVCCCVGCASCTT GCCBBVRGS VMGSCCBBDGSCCVGCASCTT Direction: Forward Position #: 3 Overlap #: 9 Alignment: VMGGMCDKBVCCCVGCASCTT --GCCBBVRGS---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 7 Combined Motif Reverse Complement Reverse Complement AAGSTGCBGGSCHBBGGSCYV GGGGMGGG AAGGKGCGGGSCHBBGGSCYV Direction: Forward Position #: 3 Overlap #: 8 Alignment: AAGSTGCBGGSCHBBGGSCYV --GGGGMGGG----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement AAGGKGCGGGSCHBBGGSCYV MSGKKRCGCWDCABTGBBCD MVGGKGCGSKBCVBHGBBCHV Direction: Forward Position #: 1 Overlap #: 20 Alignment: AAGGKGCGGGSCHBBGGSCYV MSGKKRCGCWDCABTGBBCD- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Original Motif MVGGKGCGSKBCVBHGBBCHV HGCGTGGGCGK HGSGKGSGCGKCVBHGBBCHV Direction: Forward Position #: 1 Overlap #: 11 Alignment: MVGGKGCGSKBCVBHGBBCHV HGCGTGGGCGK---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Original Motif Original Motif HGSGKGSGCGKCVBHGBBCHV DGGGYGKGGC HGGGTGBGSBKCVBHGBBCHV Direction: Forward Position #: 1 Overlap #: 10 Alignment: HGSGKGSGCGKCVBHGBBCHV DGGGYGKGGC----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Original Motif Reverse Complement HGGGTGBGSBKCVBHGBBCHV GGGGGYGGGG DGGGKBGGGGKCVBHGBBCHV Direction: Forward Position #: 1 Overlap #: 10 Alignment: HGGGTGBGSBKCVBHGBBCHV GGGGGYGGGG----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Original Motif VHGBBCHBBGYCCCCBYCCCH CCCCMAAMCAMCCMCMMMCV VHGBCCMCHRMCCMCCCCCCHMCV Direction: Forward Position #: 5 Overlap #: 17 Alignment: VHGBBCHBBGYCCCCBYCCCH--- ----CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 7 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 7 SP1 Original Motif Original Motif CCCRCCCC CCCCKCCCCC CCCCDCCCCC Direction: Backward Position #: 2 Overlap #: 8 Alignment: -CCCRCCCC- CCCCKCCCCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Original Motif Reverse Complement CCCCDCCCCC GCCYCMCCCD SCCCCCCCCH Direction: Forward Position #: 1 Overlap #: 10 Alignment: CCCCDCCCCC GCCYCMCCCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Reverse Complement Original Motif DGGGGGGGGS HGCGTGGGCGK DGSGKGGGSGK Direction: Forward Position #: 1 Overlap #: 10 Alignment: DGGGGGGGGS- HGCGTGGGCGK ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement DGSGKGGGSGK BGRRRGRGGRTGRTTYGGGG DGSGDGGGGGGTGRTTYGGGG Direction: Forward Position #: 2 Overlap #: 10 Alignment: DGSGKGGGSGK---------- -BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NFKB1 Combined Motif Original Motif Original Motif DGSGDGGGGGGTGRTTYGGGG GGGGRTTCCCC DGSGDGGGGGGTGRTTKGGGRTTCCCC Direction: Forward Position #: 17 Overlap #: 5 Alignment: DGSGDGGGGGGTGRTTYGGGG------ ----------------GGGGRTTCCCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Reverse Complement Reverse Complement GGGGAAMCCCYAAMCACCCCCCHCSCD MGCCCCCTGMCA GGGGMRCCCCCWRMCACCCCCCHCSCD Direction: Forward Position #: 5 Overlap #: 12 Alignment: GGGGAAMCCCYAAMCACCCCCCHCSCD ----MGCCCCCTGMCA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- EWSR1-FLI1 Combined Motif Reverse Complement Reverse Complement DGSGDGGGGGGTGYKWGGGGGMYCCCC CCTTCCTTCCTTCCTTCC DGSGDGGGGGGTGYKWGGGGGCCYYCCTTCCTTCCTTCC Direction: Forward Position #: 22 Overlap #: 6 Alignment: DGSGDGGGGGGTGYKWGGGGGMYCCCC------------ ---------------------CCTTCCTTCCTTCCTTCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Original Motif DGSGDGGGGGGTGYKWGGGGGCCYYCCTTCCTTCCTTCC GGGGCCCAAGGGGG DGSGDGGGGGGKSCBWVGGGGSCYYCCTTCCTTCCTTCC Direction: Forward Position #: 9 Overlap #: 14 Alignment: DGSGDGGGGGGTGYKWGGGGGCCYYCCTTCCTTCCTTCC --------GGGGCCCAAGGGGG----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif DGSGDGGGGGGKSCBWVGGGGSCYYCCTTCCTTCCTTCC BBVGCCBVGGCCTV DGSGDGGGGGGKSCBHGGSSKVCYYCCTTCCTTCCTTCC Direction: Forward Position #: 9 Overlap #: 14 Alignment: DGSGDGGGGGGKSCBWVGGGGSCYYCCTTCCTTCCTTCC --------BBVGCCBVGGCCTV----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement DGSGDGGGGGGKSCBHGGSSKVCYYCCTTCCTTCCTTCC MSGKKRCGCWDCABTGBBCD DVSGKKRSGCDKSMBHGGBCKVCYYCCTTCCTTCCTTCC Direction: Forward Position #: 2 Overlap #: 20 Alignment: DGSGDGGGGGGKSCBHGGSSKVCYYCCTTCCTTCCTTCC -MSGKKRCGCWDCABTGBBCD------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 8 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 8 REST Reverse Complement Reverse Complement TCCCAG GGYGCTGTCCATGGTGCTGAA GTGCTGAATCCCHGGGYGCTG Direction: Backward Position #: 9 Overlap #: 6 Alignment: -------TCCCAG-------- GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_1-4 Combined Motif Reverse Complement Reverse Complement CAGCKCCCHGGGATTCAGCAC TCCCCV CAGYCCCCHGGGATTCAGCAC Direction: Forward Position #: 4 Overlap #: 6 Alignment: CAGCKCCCHGGGATTCAGCAC ---TCCCCV------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Original Motif CAGYCCCCHGGGATTCAGCAC CCCCMAAMCAMCCMCMMMCV CHGGGATTCAGCACCMVHCCCCAGYCCCCHGGGAT Direction: Backward Position #: 15 Overlap #: 7 Alignment: -------------CAGYCCCCHGGGATTCAGCAC --------------CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Reverse Complement ATCCCHGGGGMCTGGGGDVYGGTGCTGAATCCCHG MGCCCCCTGMCA MRYCCCCKGRCACTGGGGDVYGGTGCTGAATCCCHG Direction: Forward Position #: 2 Overlap #: 11 Alignment: -ATCCCHGGGGMCTGGGGDVYGGTGCTGAATCCCHG MGCCCCCTGMCA------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Reverse Complement MRYCCCCKGRCACTGGGGDVYGGTGCTGAATCCCHG GYRYCCMTKGGYRSC GHRYCCCYKGGYRCYGGGGDVYGGTGCTGAATCCCHG Direction: Forward Position #: 2 Overlap #: 14 Alignment: -MRYCCCCKGRCACTGGGGDVYGGTGCTGAATCCCHG GYRYCCMTKGGYRSC---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA Combined Motif Original Motif Original Motif GHRYCCCYKGGYRCYGGGGDVYGGTGCTGAATCCCHG AAAGGTCAAAGGTCAAC GHRYCCCYKGGYRCYGGGGDVYGGTGCTGAATCMMAGGTCAAAGGTCAAC Direction: Forward Position #: 34 Overlap #: 4 Alignment: GHRYCCCYKGGYRCYGGGGDVYGGTGCTGAATCCCHG------------- ---------------------------------AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Original Motif GHRYCCCYKGGYRCYGGGGDVYGGTGCTGAATCMMAGGTCAAAGGTCAAC CCAGYYHVADCCRG GHRYCCCYKGSCRSYBVVRDCYRGTGCTGAATCMMAGGTCAAAGGTCAAC Direction: Forward Position #: 11 Overlap #: 14 Alignment: GHRYCCCYKGGYRCYGGGGDVYGGTGCTGAATCMMAGGTCAAAGGTCAAC ----------CCAGYYHVADCCRG-------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Egr1 Combined Motif Original Motif Reverse Complement GHRYCCCYKGSCRSYBVVRDCYRGTGCTGAATCMMAGGTCAAAGGTCAAC YCGCCCACGCH GYCBCCCACGCHRSYBVVRDCYRGTGCTGAATCMMAGGTCAAAGGTCAAC Direction: Forward Position #: 2 Overlap #: 11 Alignment: GHRYCCCYKGSCRSYBVVRDCYRGTGCTGAATCMMAGGTCAAAGGTCAAC -YCGCCCACGCH-------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Ar Original Motif Original Motif GYCBCCCACGCHRSYBVVRDCYRGTGCTGAATCMMAGGTCAAAGGTCAAC HWDAGHACRHHVTGTHCCHVMV HDHVGCMCABBSYGBHCBVVHCYRGTGCTGAATCMMAGGTCAAAGGTCAAC Direction: Forward Position #: 2 Overlap #: 21 Alignment: -GYCBCCCACGCHRSYBVVRDCYRGTGCTGAATCMMAGGTCAAAGGTCAAC HWDAGHACRHHVTGTHCCHVMV----------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Reverse Complement HDHVGCMCABBSYGBHCBVVHCYRGTGCTGAATCMMAGGTCAAAGGTCAAC VAGGCCBBGGCVBB HDHVGCMMGGCCBVKBCVVVHCYRGTGCTGAATCMMAGGTCAAAGGTCAAC Direction: Forward Position #: 7 Overlap #: 14 Alignment: HDHVGCMCABBSYGBHCBVVHCYRGTGCTGAATCMMAGGTCAAAGGTCAAC ------VAGGCCBBGGCVBB------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 9 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 9 Motif 11 Original Motif Original Motif CACACAVRCACACA CAYACACACACACA CACACACACACACA Direction: Forward Position #: 1 Overlap #: 14 Alignment: CACACAVRCACACA CAYACACACACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement TGTGTGTGTGTGTG BGRRRGRGGRTGRTTYGGGG TGTGKGKGDGKGTGRTTYGGGG Direction: Forward Position #: 3 Overlap #: 12 Alignment: TGTGTGTGTGTGTG-------- --BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Reverse Complement Reverse Complement CCCCMAAMCACYCDCRCRCACA AAAAAAACAAARRA CCCCAAAAMAMYMAMRVACACA Direction: Forward Position #: 5 Overlap #: 14 Alignment: CCCCMAAMCACYCDCRCRCACA ----AAAAAAACAAARRA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Combined Motif Reverse Complement Original Motif TGTGTVKYTYKRTRTTTTGGGG GGGTCAWBGRGTTCA TGTGTVKYTYKRTRTTTTGGGKCAWBGRGTTCA Direction: Forward Position #: 19 Overlap #: 4 Alignment: TGTGTVKYTYKRTRTTTTGGGG----------- ------------------GGGTCAWBGRGTTCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif TGAACKCBWTGRCCCAAAAMAMYMAMRVACACA HWDAGHACRHHVTGTHCCHVMV TGAACKMDWWGDMCMHMAHGWHCMDVVVACACA Direction: Forward Position #: 7 Overlap #: 22 Alignment: TGAACKCBWTGRCCCAAAAMAMYMAMRVACACA ------HWDAGHACRHHVTGTHCCHVMV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Reverse Complement Original Motif TGTGTVBBDRGHWCHTYHRGRDCWWDRYGTTCA HGCGTGGGCGK TGYGTGGGYGKHWCHTYHRGRDCWWDRYGTTCA Direction: Forward Position #: 1 Overlap #: 11 Alignment: TGTGTVBBDRGHWCHTYHRGRDCWWDRYGTTCA HGCGTGGGCGK---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif TGAACKMDWWGDMCMHMAHGWHYCKCCCACKCA VDBHMAGGTCACCCTGACCY TGAACKVHHWGGHCAHMVTGACCYKCCCACKCA Direction: Forward Position #: 5 Overlap #: 20 Alignment: TGAACKMDWWGDMCMHMAHGWHYCKCCCACKCA ----VDBHMAGGTCACCCTGACCY--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Original Motif TGYGTGGGYKGGTCAVRDTGHCCWHDVYGTTCA TGYCAGGGGGCR TGYSWGGGGGBRTCAVRDTGHCCWHDVYGTTCA Direction: Forward Position #: 1 Overlap #: 12 Alignment: TGYGTGGGYKGGTCAVRDTGHCCWHDVYGTTCA TGYCAGGGGGCR--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Original Motif Original Motif TGYSWGGGGGBRTCAVRDTGHCCWHDVYGTTCA DGGGYGKGGC TGGGTGGGGBBRTCAVRDTGHCCWHDVYGTTCA Direction: Forward Position #: 1 Overlap #: 10 Alignment: TGYSWGGGGGBRTCAVRDTGHCCWHDVYGTTCA DGGGYGKGGC----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif TGGGTGGGGBBRTCAVRDTGHCCWHDVYGTTCA RGGBCAAAGKYCA TGGGTGGGGBBVWMAGDBYRHCCWHDVYGTTCA Direction: Forward Position #: 8 Overlap #: 13 Alignment: TGGGTGGGGBBRTCAVRDTGHCCWHDVYGTTCA -------RGGBCAAAGKYCA------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 10 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 EWSR1-FLI1 Reverse Complement Original Motif AAAAAAACAAARRA GGAAGGAAGGAAGGAAGG GGAARRAARSAARGAAGG Direction: Forward Position #: 3 Overlap #: 14 Alignment: --AAAAAAACAAARRA-- GGAAGGAAGGAAGGAAGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 11 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 11 Motif 9 Original Motif Original Motif CAYACACACACACA CACACAVRCACACA CACACACACACACA Direction: Forward Position #: 1 Overlap #: 14 Alignment: CAYACACACACACA CACACAVRCACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement TGTGTGTGTGTGTG BGRRRGRGGRTGRTTYGGGG TGTGKGKGDGKGTGRTTYGGGG Direction: Forward Position #: 3 Overlap #: 12 Alignment: TGTGTGTGTGTGTG-------- --BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Reverse Complement Reverse Complement CCCCMAAMCACYCDCRCRCACA AAAAAAACAAARRA CCCCAAAAMAMYMAMRVACACA Direction: Forward Position #: 5 Overlap #: 14 Alignment: CCCCMAAMCACYCDCRCRCACA ----AAAAAAACAAARRA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Original Motif Reverse Complement CCCCAAAAMAMYMAMRVACACA MGCCCCCTGMCA MGCCCCMWRMCAMYMAMRVACACA Direction: Forward Position #: 3 Overlap #: 10 Alignment: --CCCCAAAAMAMYMAMRVACACA MGCCCCCTGMCA------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Reverse Complement MGCCCCMWRMCAMYMAMRVACACA YCGCCCACGCH YSBCCCMCGMMAMYMAMRVACACA Direction: Forward Position #: 1 Overlap #: 11 Alignment: MGCCCCMWRMCAMYMAMRVACACA YCGCCCACGCH------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Reverse Complement YSBCCCMCGMMAMYMAMRVACACA MGGTCAGGGTGACCTRDBHV MGGYCMVVGHVACCHRVDVDCACA Direction: Forward Position #: 1 Overlap #: 20 Alignment: YSBCCCMCGMMAMYMAMRVACACA MGGTCAGGGTGACCTRDBHV---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Original Motif TGTGDVHBKHGGTVHCVBYGKCCR DGGGYGKGGC TGKGYGBGGHGGTVHCVBYGKCCR Direction: Forward Position #: 1 Overlap #: 10 Alignment: TGTGDVHBKHGGTVHCVBYGKCCR DGGGYGKGGC-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Original Motif Reverse Complement TGKGYGBGGHGGTVHCVBYGKCCR GGGGGYGGGG TGKGYGGGGBBGKGVCVBYGKCCR Direction: Forward Position #: 6 Overlap #: 10 Alignment: TGKGYGBGGHGGTVHCVBYGKCCR -----GGGGGYGGGG--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 7 Original Motif Reverse Complement TGKGYGGGGBBGKGVCVBYGKCCR GGGGMGGG KGGGHGGGGBBGKGVCVBYGKCCR Direction: Forward Position #: 1 Overlap #: 8 Alignment: TGKGYGGGGBBGKGVCVBYGKCCR GGGGMGGG---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Original Motif Original Motif KGGGHGGGGBBGKGVCVBYGKCCR VBACGTGV VKRSGTGVGGBBGKGVCVBYGKCCR Direction: Forward Position #: 2 Overlap #: 7 Alignment: -KGGGHGGGGBBGKGVCVBYGKCCR VBACGTGV----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 12 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Pax5 Original Motif Original Motif BBVGCCBVGGCCTV DGVBCABTGDWGCGKRRCSR RCSRVBVDSYGVGGCSTRDG Direction: Backward Position #: 5 Overlap #: 14 Alignment: --BBVGCCBVGGCCTV---- DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement CDMASGCCBCKSDVBVMSGK BAGGYCABHBTGACCKHV CDVAGGCCDBBBTGVCCBDD Direction: Forward Position #: 3 Overlap #: 18 Alignment: CDMASGCCBCKSDVBVMSGK --BAGGYCABHBTGACCKHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif CDVAGGCCDBBBTGVCCBDD VDBHMAGGTCACCCTGACCY CDVAVGCCHVGGTSACCBTGACCY Direction: Forward Position #: 5 Overlap #: 16 Alignment: CDVAGGCCDBBBTGVCCBDD---- ----VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Tcfcp2l1 Original Motif Reverse Complement CDVAVGCCHVGGTSACCBTGACCY CKGGDTBDMMCTGG CKGRDKBBMHSKKGACCBTGACCY Direction: Forward Position #: 1 Overlap #: 14 Alignment: CDVAVGCCHVGGTSACCBTGACCY CKGGDTBDMMCTGG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Original Motif Reverse Complement CKGRDKBBMHSKKGACCBTGACCY GYRYCCMTKGGYRSC CKGRBRYCCMHKGGHVCCTGACCY Direction: Forward Position #: 4 Overlap #: 15 Alignment: CKGRDKBBMHSKKGACCBTGACCY ---GYRYCCMTKGGYRSC------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Reverse Complement CKGRBRYCCMHKGGHVCCTGACCY CCCCCTTGGGCCCC CKGRBVCCCCYTGGVCCCYGACCY Direction: Forward Position #: 6 Overlap #: 14 Alignment: CKGRBRYCCMHKGGHVCCTGACCY -----CCCCCTTGGGCCCC----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Reverse Complement Original Motif MGGTCKGGGVCCAMGGGGVBMCRG TTCAGCACCATGGACAGCKCC MGGTYSRGSACCAHGGRSAGCBVS Direction: Forward Position #: 4 Overlap #: 21 Alignment: MGGTCKGGGVCCAMGGGGVBMCRG ---TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Ar Reverse Complement Original Motif SVBGCTSKCCHTGGTSCKSMACCY HWDAGHACRHHVTGTHCCHVMV VDHRSHVCMCHDKGTVCBBVMCCY Direction: Forward Position #: 1 Overlap #: 22 Alignment: SVBGCTSKCCHTGGTSCKSMACCY HWDAGHACRHHVTGTHCCHVMV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Reverse Complement MGGYBBBGVACYDDGRGBHSKHDV TGRCCTKTGHCCKAB HGRYCTKKVHCCDDBRGBHSKHDV Direction: Forward Position #: 1 Overlap #: 15 Alignment: MGGYBBBGVACYDDGRGBHSKHDV TGRCCTKTGHCCKAB--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Original Motif HGRYCTKKVHCCDDBRGBHSKHDV RGKTCABVVRGAGGTCA HGRYVGKTSACVDRVRGKTCDHDV Direction: Forward Position #: 5 Overlap #: 17 Alignment: HGRYCTKKVHCCDDBRGBHSKHDV ----RGKTCABVVRGAGGTCA--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 13 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Ar Original Motif Original Motif GSMMCCYARGGKKKC HWDAGHACRHHVTGTHCCHVMV HVMVRGMACMYHRKGTDCCHWD Direction: Backward Position #: 5 Overlap #: 15 Alignment: ---GSMMCCYARGGKKKC---- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif DWHGGDACYMHKRGTYCMVRVD DGVBCABTGDWGCGKRRCSR DWHGDRDCCMHKGGWGCRDRVCSR Direction: Forward Position #: 5 Overlap #: 18 Alignment: DWHGGDACYMHKRGTYCMVRVD-- ----DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Reverse Complement DWHGDRDCCMHKGGWGCRDRVCSR GGYGCTGTCCATGGTGCTGAA DDHGCTGYCCHTGGTGCDGAVCSR Direction: Forward Position #: 1 Overlap #: 21 Alignment: DWHGDRDCCMHKGGWGCRDRVCSR GGYGCTGTCCATGGTGCTGAA--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Combined Motif Original Motif Reverse Complement DDHGCTGYCCHTGGTGCDGAVCSR TGAACKCBWTGACCC DDHGCTGYCCHTGGTGCTGAACBVBWTGACCC Direction: Forward Position #: 18 Overlap #: 7 Alignment: DDHGCTGYCCHTGGTGCDGAVCSR-------- -----------------TGAACKCBWTGACCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif GGGTCAWBVBGTTCAGCACCAHGGMCAGCDHH GGGGCCCAAGGGGG GGGGYCAWVGGGKKCAGCACCAHGGMCAGCDHH Direction: Forward Position #: 2 Overlap #: 13 Alignment: -GGGTCAWBVBGTTCAGCACCAHGGMCAGCDHH GGGGCCCAAGGGGG------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Original Motif Reverse Complement GGGGYCAWVGGGKKCAGCACCAHGGMCAGCDHH VAGGCCBBGGCVBB GRGGCCHHVGSGBBCAGCACCAHGGMCAGCDHH Direction: Forward Position #: 1 Overlap #: 14 Alignment: GGGGYCAWVGGGKKCAGCACCAHGGMCAGCDHH VAGGCCBBGGCVBB------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif DDHGCTGYCCHTGGTGCTGBBCSCVHDGGCCKC VDBHMAGGTCACCCTGACCY DDHVCDGKYCABSSTGMYSYBCSCVHDGGCCKC Direction: Forward Position #: 1 Overlap #: 20 Alignment: DDHGCTGYCCHTGGTGCTGBBCSCVHDGGCCKC VDBHMAGGTCACCCTGACCY------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement GRGGCCHHVGSGBMSKRCASSBTGKYCDGVDHH BGRRRGRGGRTGRTTYGGGG GRGGCCHHGGVGGVGGRYRVYTTGGGVDGVDHH Direction: Forward Position #: 8 Overlap #: 20 Alignment: GRGGCCHHVGSGBMSKRCASSBTGKYCDGVDHH -------BGRRRGRGGRTGRTTYGGGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Original Motif Original Motif GRGGCCHHGGVGGVGGRYRVYTTGGGVDGVDHH TGYCAGGGGGCR GRGGCCHTGBVDGGGGGYRVYTTGGGVDGVDHH Direction: Forward Position #: 8 Overlap #: 12 Alignment: GRGGCCHHGGVGGVGGRYRVYTTGGGVDGVDHH -------TGYCAGGGGGCR-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Tcfcp2l1 Original Motif Reverse Complement GRGGCCHTGBVDGGGGGYRVYTTGGGVDGVDHH CKGGDTBDMMCTGG SDGGBYHBVHCDGGGGGYRVYTTGGGVDGVDHH Direction: Forward Position #: 1 Overlap #: 14 Alignment: GRGGCCHTGBVDGGGGGYRVYTTGGGVDGVDHH CKGGDTBDMMCTGG------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 14 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZEB1 RORA_1 Original Motif Reverse Complement CACCTD TGACCTDVWT VWTSACCTDT Direction: Backward Position #: 4 Overlap #: 6 Alignment: -CACCTD--- TGACCTDVWT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif VWTSACCTDT TTCAGCACCATGGACAGCKCC TTSAKSACCWDKGACAGCKCC Direction: Forward Position #: 3 Overlap #: 10 Alignment: --VWTSACCTDT--------- TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Arnt Combined Motif Reverse Complement Original Motif GGYGCTGTCRDWGGTSYTSAA CACGTG GGYGCTGTCRMASGTGYTSAA Direction: Forward Position #: 11 Overlap #: 6 Alignment: GGYGCTGTCRDWGGTSYTSAA ----------CACGTG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Esrrb Combined Motif Original Motif Original Motif GGYGCTGTCRMASGTGYTSAA CACGTG GGYGCTGTCRCACGTGYTSAA Direction: Forward Position #: 11 Overlap #: 6 Alignment: GGYGCTGTCRMASGTGYTSAA ----------CACGTG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA Combined Motif Original Motif Original Motif GGYGCTGTCRCACGTGYTSAA AAAGGTCAAAGGTCAAC GGMRMKGTCAMASGTSAWSAA Direction: Forward Position #: 3 Overlap #: 17 Alignment: GGYGCTGTCRCACGTGYTSAA --AAAGGTCAAAGGTCAAC-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HIF1AARNT Combined Motif Reverse Complement Reverse Complement TTSWTSACSTYTGACYRMYCC VCACGTBV TTSWBCACGTYBGACYRMYCC Direction: Forward Position #: 5 Overlap #: 8 Alignment: TTSWTSACSTYTGACYRMYCC ----VCACGTBV--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Original Motif GGMRMKGTCVMACGTGVWSAA TGYCAGGGGGCR TGKVAGGGGKCRMACGTGVWSAA Direction: Forward Position #: 3 Overlap #: 10 Alignment: --GGMRMKGTCVMACGTGVWSAA TGYCAGGGGGCR----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Original Motif TGKVAGGGGKCRMACGTGVWSAA BTRGGDCARAGGKCA TGKVHDRGGKCAAASGTSAWSAA Direction: Forward Position #: 5 Overlap #: 15 Alignment: TGKVAGGGGKCRMACGTGVWSAA ----BTRGGDCARAGGKCA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MYCMAX Combined Motif Reverse Complement Original Motif TTSWTSACSTTTGRCCMHHVYCA RASCACGTGGT TTVABCACGTGKBRCCMHHVYCA Direction: Forward Position #: 3 Overlap #: 11 Alignment: TTSWTSACSTTTGRCCMHHVYCA --RASCACGTGGT---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR4A2 Original Motif Original Motif TTVABCACGTGKBRCCMHHVYCA AAGGTCAC DWGRTCACGTGKBRCCMHHVYCA Direction: Forward Position #: 1 Overlap #: 8 Alignment: TTVABCACGTGKBRCCMHHVYCA AAGGTCAC--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 15 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TFAP2A Zfx Reverse Complement Original Motif SCMVBBGGC BBVGCCBVGGCCTV TVSCCBVGGSCBBV Direction: Backward Position #: 3 Overlap #: 9 Alignment: ---SCMVBBGGC-- BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif VBBGSCCVBGGSVA GGGGCCCAAGGGGG GGGGSCCDVGGGGR Direction: Forward Position #: 1 Overlap #: 14 Alignment: VBBGSCCVBGGSVA GGGGCCCAAGGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Original Motif GGGGSCCDVGGGGR GSMMCCYARGGKKKC GSVVCCYAVGGGKDC Direction: Forward Position #: 1 Overlap #: 14 Alignment: GGGGSCCDVGGGGR- GSMMCCYARGGKKKC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif GHYCCCBTKGGVVSC VDBHMAGGTCACCCTGACCY GHBBCCBWGGKCASCCTGACCY Direction: Forward Position #: 3 Overlap #: 13 Alignment: GHYCCCBTKGGVVSC------- --VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Original Motif Reverse Complement GHBBCCBWGGKCASCCTGACCY BAGGYCABHBTGACCKHV VMGBYCHHBGTSACCBTGACCY Direction: Forward Position #: 1 Overlap #: 18 Alignment: GHBBCCBWGGKCASCCTGACCY BAGGYCABHBTGACCKHV---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn Combined Motif Original Motif Original Motif VMGBYCHHBGTSACCBTGACCY HSCACGTGGC VMSCACRTGGBSACCBTGACCY Direction: Forward Position #: 2 Overlap #: 10 Alignment: VMGBYCHHBGTSACCBTGACCY -HSCACGTGGC----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement MGGTCAVGGTSVCCAMGTGSYV MSGKKRCGCWDCABTGBBCD MGGTCVGGGDCVCHDCRBBVYBCD Direction: Forward Position #: 5 Overlap #: 18 Alignment: MGGTCAVGGTSVCCAMGTGSYV-- ----MSGKKRCGCWDCABTGBBCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Original Motif MGGTCVGGGDCVCHDCRBBVYBCD RGKTCABVVRGAGGTCA MGGTCRGKTBMVCBDSRGKBCACD Direction: Forward Position #: 6 Overlap #: 17 Alignment: MGGTCVGGGDCVCHDCRBBVYBCD -----RGKTCABVVRGAGGTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Myc Combined Motif Original Motif Reverse Complement MGGTCRGKTBMVCBDSRGKBCACD DCCACGTGCV MGGYCASGTGMVCBDSRGKBCACD Direction: Forward Position #: 3 Overlap #: 10 Alignment: MGGTCRGKTBMVCBDSRGKBCACD --DCCACGTGCV------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Original Motif MGGYCASGTGMVCBDSRGKBCACD CCAGYYHVADCCRG MGGYCMVGTBVVVDCCRGKBCACD Direction: Forward Position #: 5 Overlap #: 14 Alignment: MGGYCASGTGMVCBDSRGKBCACD ----CCAGYYHVADCCRG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 16 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 RREB1 Reverse Complement Reverse Complement GGGGGYGGGG BGRRRGRGGRTGRTTYGGGG BGGGGGVGGGKGRTTYGGGG Direction: Forward Position #: 2 Overlap #: 10 Alignment: -GGGGGYGGGG--------- BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Original Motif Original Motif BGGGGGVGGGKGRTTYGGGG BBVGCCBVGGCCTV BSGGSSBRGGYSKBTYGGGG Direction: Forward Position #: 1 Overlap #: 14 Alignment: BGGGGGVGGGKGRTTYGGGG BBVGCCBVGGCCTV------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Reverse Complement CCCCMAVRSKCCMBSSCCSB CCCCCTTGGGCCCC CCCCMHWRGGCCCCSSCCSB Direction: Forward Position #: 1 Overlap #: 14 Alignment: CCCCMAVRSKCCMBSSCCSB CCCCCTTGGGCCCC------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Reverse Complement CCCCMHWRGGCCCCSSCCSB TGRCCTKTGHCCKAB YSMCCTDTGBCCBVSSCCSB Direction: Forward Position #: 1 Overlap #: 15 Alignment: CCCCMHWRGGCCCCSSCCSB TGRCCTKTGHCCKAB----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Original Motif BSGGSSVBGGBCADAGGRSK DGGGYGKGGC DGGGBGKGGSBCADAGGRSK Direction: Forward Position #: 1 Overlap #: 10 Alignment: BSGGSSVBGGBCADAGGRSK DGGGYGKGGC---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Original Motif DGGGBGKGGSBCADAGGRSK HGCGTGGGCGK HGSGTGGGSGBCADAGGRSK Direction: Forward Position #: 1 Overlap #: 11 Alignment: DGGGBGKGGSBCADAGGRSK HGCGTGGGCGK--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif HGSGTGGGSGBCADAGGRSK DGVBCABTGDWGCGKRRCSR HGSGDGDGBVBYRDWGSGKDRCSR Direction: Forward Position #: 5 Overlap #: 16 Alignment: HGSGTGGGSGBCADAGGRSK---- ----DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MZF1_5-13 Original Motif Original Motif HGSGDGDGBVBYRDWGSGKDRCSR BKAGGGGDAD BGMGGGGGVVBYRDWGSGKDRCSR Direction: Forward Position #: 1 Overlap #: 10 Alignment: HGSGDGDGBVBYRDWGSGKDRCSR BKAGGGGDAD-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Reverse Complement Reverse Complement MSGKHYCSCWDMKBBBCCCCCYCV MGCCCCCTGMCA MSVKCCCCCWDMCVBBCCCCCYCV Direction: Forward Position #: 3 Overlap #: 12 Alignment: MSGKHYCSCWDMKBBBCCCCCYCV --MGCCCCCTGMCA---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- EWSR1-FLI1 Combined Motif Original Motif Reverse Complement MSVKCCCCCWDMCVBBCCCCCYCV CCTTCCTTCCTTCCTTCC MSVKCCCCCWDMCVBBCCCCYTCCTTCCTTCCTTCC Direction: Forward Position #: 19 Overlap #: 6 Alignment: MSVKCCCCCWDMCVBBCCCCCYCV------------ ------------------CCTTCCTTCCTTCCTTCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 17 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Ar Reverse Complement Original Motif TGAACKCBWTGACCC HWDAGHACRHHVTGTHCCHVMV HVMVDGAACDCBHTGWCCCHWD Direction: Backward Position #: 5 Overlap #: 15 Alignment: ---TGAACKCBWTGACCC---- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Reverse Complement HVMVDGAACDCBHTGWCCCHWD BAGGYCABHBTGACCKHV HVMVAGRACAHBVTGACCBHDD Direction: Forward Position #: 4 Overlap #: 18 Alignment: HVMVDGAACDCBHTGWCCCHWD ---BAGGYCABHBTGACCKHV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Reverse Complement Reverse Complement DDHBGGTCAVBDTGTKCTVRVD TGACCTCKVVBTGAYCK DTDDSSTCWVVDTGABCKVRVD Direction: Forward Position #: 2 Overlap #: 17 Alignment: DDHBGGTCAVBDTGTKCTVRVD -TGACCTCKVVBTGAYCK---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Original Motif HVMVRGVTCAHVVWGASSDHAD VDBHMAGGTCACCCTGACCY VDVMVAGGTCABVVTGACCBHAD Direction: Forward Position #: 2 Overlap #: 19 Alignment: -HVMVRGVTCAHVVWGASSDHAD VDBHMAGGTCACCCTGACCY--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Reverse Complement VDVMVAGGTCABVVTGACCBHAD GYRYCCMTKGGYRSC GYRBCCMWGGKCASCVTGACCBHAD Direction: Forward Position #: 3 Overlap #: 13 Alignment: --VDVMVAGGTCABVVTGACCBHAD GYRYCCMTKGGYRSC---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 18 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 ESR1 Reverse Complement Reverse Complement BGRRRGRGGRTGRTTYGGGG MGGTCAGGGTGACCTRDBHV VVGGDSAGGGTGRYYTGGGVB Direction: Backward Position #: 2 Overlap #: 19 Alignment: BGRRRGRGGRTGRTTYGGGG- -MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Reverse Complement BVCCCAKKKCACCCTSDCCVV VRVDGGHACAVDDKGTHCTDWH BVVVVRGDWCAVBBTGTHCBDWH Direction: Forward Position #: 2 Overlap #: 20 Alignment: BVCCCAKKKCACCCTSDCCVV-- -VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif BVVVVRGDWCAVBBTGTHCBDWH VHRGGTCABDBTGMCCTB BVVVHRGGTCAVBBTGHCCTBWH Direction: Forward Position #: 4 Overlap #: 18 Alignment: BVVVVRGDWCAVBBTGTHCBDWH ---VHRGGTCABDBTGMCCTB-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement BVVVHRGGTCAVBBTGHCCTBWH MSGKKRCGCWDCABTGBBCD HVGBBRSGYHWCVBTGHHCDBWH Direction: Forward Position #: 1 Overlap #: 20 Alignment: BVVVHRGGTCAVBBTGHCCTBWH MSGKKRCGCWDCABTGBBCD--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Original Motif Reverse Complement HVGBBRSGYHWCVBTGHHCDBWH CCCCCTTGGGCCCC CCCCSBTRGGCCMCVBTGHHCDBWH Direction: Forward Position #: 3 Overlap #: 12 Alignment: --HVGBBRSGYHWCVBTGHHCDBWH CCCCCTTGGGCCCC----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 19 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Ar Reverse Complement Reverse Complement GGYGCTGTCCATGGTGCTGAA VRVDGGHACAVDDKGTHCTDWH GVHGSTRYMCDDKGTBCTKAHV Direction: Backward Position #: 1 Overlap #: 21 Alignment: -GGYGCTGTCCATGGTGCTGAA VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement VHTYAGBACYDDGRKKASCDVC MSGKKRCGCWDCABTGBBCD MVKBDGCRCHDBRGKKHBCDVC Direction: Forward Position #: 1 Overlap #: 20 Alignment: VHTYAGBACYDDGRKKASCDVC MSGKKRCGCWDCABTGBBCD-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Reverse Complement MVKBDGCRCHDBRGKKHBCDVC MGGTCAGGGTGACCTRDBHV MVKBVGSDCADBVKGDCCHDVVHV Direction: Forward Position #: 5 Overlap #: 18 Alignment: MVKBDGCRCHDBRGKKHBCDVC-- ----MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Reverse Complement Reverse Complement VDVVHHGGDCRVBHTGDSCBVYVR BAGGYCABHBTGACCKHV VVGGHCRBBBTGVCYGDVCBVYVR Direction: Forward Position #: 1 Overlap #: 18 Alignment: VDVVHHGGDCRVBHTGDSCBVYVR BAGGYCABHBTGACCKHV------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Original Motif VVGGHCRBBBTGVCYGDVCBVYVR RGGBCAAAGKYCA VGGBCAAAGBTSACYGDVCBVYVR Direction: Forward Position #: 1 Overlap #: 13 Alignment: VVGGHCRBBBTGVCYGDVCBVYVR RGGBCAAAGKYCA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Reverse Complement VGGBCAAAGBTSACYGDVCBVYVR TGRCCTKTGHCCKAB DGRCCHDTGBYCDMBGDVCBVYVR Direction: Forward Position #: 1 Overlap #: 15 Alignment: VGGBCAAAGBTSACYGDVCBVYVR TGRCCTKTGHCCKAB--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Reverse Complement DGRCCHDTGBYCDMBGDVCBVYVR CKGGDTBDMMCTGG DGRCCCDKGBBBDMHSDGSBVYVR Direction: Forward Position #: 6 Overlap #: 14 Alignment: DGRCCHDTGBYCDMBGDVCBVYVR -----CKGGDTBDMMCTGG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Original Motif MVKBVSCDSDYHBVVCYDGGGMCD BBVGCCBVGGCCTV MVKBVSBVGVYBVGGCCTGGGMCD Direction: Forward Position #: 6 Overlap #: 14 Alignment: MVKBVSCDSDYHBVVCYDGGGMCD -----BBVGCCBVGGCCTV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Combined Motif Original Motif Original Motif MVKBVSBVGVYBVGGCCTGGGMCD GGGTCAWBGRGTTCA MVKBVSBVGVYBVGGCCTGGGTCAWBGRGTTCA Direction: Forward Position #: 19 Overlap #: 6 Alignment: MVKBVSBVGVYBVGGCCTGGGMCD--------- ------------------GGGTCAWBGRGTTCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Original Motif MVKBVSBVGVYBVGGCCTGGGTCAWBGRGTTCA RGKTCABVVRGAGGTCA MVKBVSBRGBTCAVGSVDRGGTCAWBGRGTTCA Direction: Forward Position #: 8 Overlap #: 17 Alignment: MVKBVSBVGVYBVGGCCTGGGTCAWBGRGTTCA -------RGKTCABVVRGAGGTCA--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 20 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA NR1H2RXRA Original Motif Original Motif BTRGGDCARAGGKCA AAAGGTCAAAGGTCAAC ACVDRGGTCAAAGGTCA Direction: Backward Position #: 3 Overlap #: 15 Alignment: BTRGGDCARAGGKCA-- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Reverse Complement Reverse Complement TGACCTTTGACCKDBGT TGACCTCKVVBTGAYCK TGACCTBTSVCYKAYCT Direction: Forward Position #: 1 Overlap #: 17 Alignment: TGACCTTTGACCKDBGT TGACCTCKVVBTGAYCK ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Original Motif Original Motif TGACCTBTSVCYKAYCT VHRGGTCABDBTGMCCTB TDASSTCWBVBTGACCTB Direction: Forward Position #: 1 Overlap #: 17 Alignment: TGACCTBTSVCYKAYCT- VHRGGTCABDBTGMCCTB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Reverse Complement BAGGTCABVBWGASSTHA VRVDGGHACAVDDKGTHCTDWH BAGGDCVGGHWSASBKBGTHCTDWH Direction: Forward Position #: 4 Overlap #: 15 Alignment: BAGGTCABVBWGASSTHA------- ---VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Pax5 Original Motif Reverse Complement BAGGDCVGGHWSASBKBGTHCTDWH MSGKKRCGCWDCABTGBBCD HVGKKVMGCDWCASBKBDYDCTDWH Direction: Forward Position #: 1 Overlap #: 20 Alignment: BAGGDCVGGHWSASBKBGTHCTDWH MSGKKRCGCWDCABTGBBCD----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Reverse Complement HVGKKVMGCDWCASBKBDYDCTDWH MGGTCAGGGTGACCTRDBHV MRGBBAVGSTDVMCTDBBHHCTDWH Direction: Forward Position #: 1 Overlap #: 20 Alignment: HVGKKVMGCDWCASBKBDYDCTDWH MGGTCAGGGTGACCTRDBHV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Reverse Complement MRGBBAVGSTDVMCTDBBHHCTDWH BGRRRGRGGRTGRTTYGGGG BVRGDGRGGGTGVYYTGGGVHCTDWH Direction: Forward Position #: 2 Overlap #: 19 Alignment: -MRGBBAVGSTDVMCTDBBHHCTDWH BGRRRGRGGRTGRTTYGGGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Original Motif Reverse Complement BVRGDGRGGGTGVYYTGGGVHCTDWH GGYGCTGTCCATGGTGCTGAA BVRGDGRVGCTGDCCHKGGTBCTKAH Direction: Forward Position #: 6 Overlap #: 21 Alignment: BVRGDGRGGGTGVYYTGGGVHCTDWH -----GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Reverse Complement Reverse Complement HTYAGBACCYHGGDCAGCVMCHCMVB AKGYYCAAAGRTCA HTVRGBDCMMAGGTCAGCVMCHCMVB Direction: Forward Position #: 3 Overlap #: 14 Alignment: HTYAGBACCYHGGDCAGCVMCHCMVB --AKGYYCAAAGRTCA---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Original Motif HTVRGBDCMMAGGTCAGCVMCHCMVB GGGGCCCAAGGGGG HTGRGGBCMAAGGGSRGCVMCHCMVB Direction: Forward Position #: 3 Overlap #: 14 Alignment: HTVRGBDCMMAGGTCAGCVMCHCMVB --GGGGCCCAAGGGGG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 21 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Zfp423 Original Motif Original Motif GGGGCCCAAGGGGG GSMMCCYARGGKKKC GGSVCCYARGGGGGC Direction: Forward Position #: 1 Overlap #: 14 Alignment: GGGGCCCAAGGGGG- GSMMCCYARGGKKKC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement GGSVCCYARGGGGGC BGRRRGRGGRTGRTTYGGGG GGBGSCHRRGGGKGVTTYGGGG Direction: Forward Position #: 3 Overlap #: 13 Alignment: GGSVCCYARGGGGGC------- --BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Original Motif GGBGSCHRRGGGKGVTTYGGGG BTRGGDCARAGGKCA GBVGGVVARRGGKSATTYGGGG Direction: Forward Position #: 1 Overlap #: 15 Alignment: GGBGSCHRRGGGKGVTTYGGGG BTRGGDCARAGGKCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Original Motif Original Motif GBVGGVVARRGGKSATTYGGGG BBVGCCBVGGCCTV SBVGSCBAGGSSTSATTYGGGG Direction: Forward Position #: 1 Overlap #: 14 Alignment: GBVGGVVARRGGKSATTYGGGG BBVGCCBVGGCCTV-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Tcfcp2l1 Original Motif Original Motif SBVGSCBAGGSSTSATTYGGGG CCAGYYHVADCCRG CCRGBYBVRRCCDGATTYGGGG Direction: Forward Position #: 1 Overlap #: 14 Alignment: SBVGSCBAGGSSTSATTYGGGG CCAGYYHVADCCRG-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Original Motif CCRGBYBVRRCCDGATTYGGGG RGKTCABVVRGAGGTCA RGBTVRBBBRRRSSTSATTYGGGG Direction: Forward Position #: 3 Overlap #: 15 Alignment: --CCRGBYBVRRCCDGATTYGGGG RGKTCABVVRGAGGTCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement CCCCMAATSASSKMKBBBKVABCK MSGKKRCGCWDCABTGBBCD CCCCMRDTVMSCTHBVBBKBHCCK Direction: Forward Position #: 4 Overlap #: 20 Alignment: CCCCMAATSASSKMKBBBKVABCK ---MSGKKRCGCWDCABTGBBCD- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Combined Motif Reverse Complement Original Motif RGGHBYVBBBDAGSYVADKYGGGG GGGTCAWBGRGTTCA RGGGGTCAHBGRGTTCADKYGGGG Direction: Forward Position #: 3 Overlap #: 15 Alignment: RGGHBYVBBBDAGSYVADKYGGGG --GGGTCAWBGRGTTCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Reverse Complement RGGGGTCAHBGRGTTCADKYGGGG TGMYCTTTGBCCK RGGGGTVMYCKDKKBCMDKYGGGG Direction: Forward Position #: 6 Overlap #: 13 Alignment: RGGGGTCAHBGRGTTCADKYGGGG -----TGMYCTTTGBCCK------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Original Motif Original Motif RGGGGTVMYCKDKKBCMDKYGGGG TGAMCTTTGMMCYT TGAVSKKTGMHCHDKKBCMDKYGGGG Direction: Forward Position #: 3 Overlap #: 12 Alignment: --RGGGGTVMYCKDKKBCMDKYGGGG TGAMCTTTGMMCYT------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 22 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 NR1H2RXRA Original Motif Reverse Complement TGAMCTTTGMMCYT GTTGACCTTTGACCTTT TTGACCTTTGACCTTGT Direction: Backward Position #: 2 Overlap #: 14 Alignment: --TGAMCTTTGMMCYT- GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif ACAAGGTCAAAGGTCAA BTRGGDCARAGGKCA ASDRGGKCAAAGGTCAA Direction: Forward Position #: 2 Overlap #: 15 Alignment: ACAAGGTCAAAGGTCAA -BTRGGDCARAGGKCA- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Original Motif ASDRGGKCAAAGGTCAA RGKTCABVVRGAGGTCA RRBTVRDBSARAGGTCAA Direction: Forward Position #: 2 Overlap #: 16 Alignment: -ASDRGGKCAAAGGTCAA RGKTCABVVRGAGGTCA- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif RRBTVRDBSARAGGTCAA VHRGGTCABDBTGMCCTB RRBHHRGGBMAVGGTSAMCTB Direction: Forward Position #: 4 Overlap #: 15 Alignment: RRBTVRDBSARAGGTCAA--- ---VHRGGTCABDBTGMCCTB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif BAGRTSACCBTRVCCKHHBMK TTCAGCACCATGGACAGCKCC TTCAGCACCATGGASAKSRCCBTRVCCKHHBMK Direction: Forward Position #: 13 Overlap #: 9 Alignment: ------------BAGRTSACCBTRVCCKHHBMK TTCAGCACCATGGACAGCKCC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement RRBHHRGGBMAVGGKSYTSTCCATGGTGCTGAA MSGKKRCGCWDCABTGBBCD VRGBBRVGCHDVRBTGYTCTCCATGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 20 Alignment: RRBHHRGGBMAVGGKSYTSTCCATGGTGCTGAA MSGKKRCGCWDCABTGBBCD------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Reverse Complement Original Motif TTCAGCACCATGGAGAKCABMVDHGCVKVVCMB RGGBCAAAGKYCA TTCAGBACMAWGGHSAKCABMVDHGCVKVVCMB Direction: Forward Position #: 4 Overlap #: 13 Alignment: TTCAGCACCATGGAGAKCABMVDHGCVKVVCMB ---RGGBCAAAGKYCA----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Reverse Complement VRGBBRVGCHDVRBTGYTSHCCWTRGTBCTGAA VAGGCCBBGGCVBB VAGGCMBBBVHVVBTGYTSHCCWTRGTBCTGAA Direction: Forward Position #: 1 Overlap #: 14 Alignment: VRGBBRVGCHDVRBTGYTSHCCWTRGTBCTGAA VAGGCCBBGGCVBB------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif VAGGCMBBBVHVVBTGYTSHCCWTRGTBCTGAA VDBHMAGGTCACCCTGACCY VAGGCMBVBBHVVGKKCWSHCYDWVSTBCTGAA Direction: Forward Position #: 8 Overlap #: 20 Alignment: VAGGCMBBBVHVVBTGYTSHCCWTRGTBCTGAA -------VDBHMAGGTCACCCTGACCY------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Combined Motif Reverse Complement Original Motif TTCAGBASVWHKGDSWGRYCBVDBBVBRGCCTV GGGTCAWBGRGTTCA TTCRGGTCRWHGRGTTSRYCBVDBBVBRGCCTV Direction: Forward Position #: 4 Overlap #: 15 Alignment: TTCAGBASVWHKGDSWGRYCBVDBBVBRGCCTV ---GGGTCAWBGRGTTCA--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 23 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_1-4 INSM1 Reverse Complement Reverse Complement TCCCCV MGCCCCCTGMCA GMCAYCCCCWMG Direction: Backward Position #: 5 Overlap #: 6 Alignment: --TCCCCV---- MGCCCCCTGMCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MZF1_5-13 Reverse Complement Original Motif CRWGGGGMTGYC BKAGGGGDAD BDAGGGGVWGYC Direction: Forward Position #: 1 Overlap #: 10 Alignment: CRWGGGGMTGYC BKAGGGGDAD-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Reverse Complement GMCWBCCCCTHB GCCYCMCCCD GCCHCCCCCWHB Direction: Forward Position #: 1 Overlap #: 10 Alignment: GMCWBCCCCTHB GCCYCMCCCD-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Reverse Complement Original Motif BDWGGGGGHGGC GGGGCCCAAGGGGG BDGGGGSSHRRBGGGG Direction: Forward Position #: 3 Overlap #: 10 Alignment: BDWGGGGGHGGC---- --GGGGCCCAAGGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 8 Reverse Complement Reverse Complement CCCCBKKDSSCCCCHB TCCCAG YCCCMGKDSSCCCCHB Direction: Forward Position #: 1 Overlap #: 6 Alignment: CCCCBKKDSSCCCCHB TCCCAG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Original Motif Original Motif YCCCMGKDSSCCCCHB CCCCKCCCCC CCCCVSBBCCCCCCHB Direction: Forward Position #: 1 Overlap #: 10 Alignment: YCCCMGKDSSCCCCHB CCCCKCCCCC------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement BDGGGGGGBBSVGGGG BGRRRGRGGRTGRTTYGGGG BDGGGGGDGVGGGKGGTTYGGGG Direction: Forward Position #: 4 Overlap #: 13 Alignment: BDGGGGGGBBSVGGGG------- ---BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NFKB1 Combined Motif Original Motif Original Motif BDGGGGGDGVGGGKGGTTYGGGG GGGGRTTCCCC BDGGGGGDGVGGGKGGTTKGGGRTTCCCC Direction: Forward Position #: 19 Overlap #: 5 Alignment: BDGGGGGDGVGGGKGGTTYGGGG------ ------------------GGGGRTTCCCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Original Motif Original Motif BDGGGGGDGVGGGKGGTTKGGGRTTCCCC TTCAGCACCATGGACAGCKCC BDGGGGGDGVGGGKGGTTKGGGRTTCMSCACCATGGACAGCKCC Direction: Forward Position #: 24 Overlap #: 6 Alignment: BDGGGGGDGVGGGKGGTTKGGGRTTCCCC--------------- -----------------------TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Ar Original Motif Reverse Complement BDGGGGGDGVGGGKGGTTKGGGRTTCMSCACCATGGACAGCKCC VRVDGGHACAVDDKGTHCTDWH BRVBGGDASVSGGKGKTYKGRDRTTCMSCACCATGGACAGCKCC Direction: Forward Position #: 1 Overlap #: 22 Alignment: BDGGGGGDGVGGGKGGTTKGGGRTTCMSCACCATGGACAGCKCC VRVDGGHACAVDDKGTHCTDWH---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 24 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar REST Reverse Complement Reverse Complement VRVDGGHACAVDDKGTHCTDWH GGYGCTGTCCATGGTGCTGAA GVHGSTRYMCDDKGTBCTKAHV Direction: Backward Position #: 1 Overlap #: 21 Alignment: VRVDGGHACAVDDKGTHCTDWH -GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement VHTYAGBACYDDGRKKASCDVC MSGKKRCGCWDCABTGBBCD MVKBDGCRCHDBRGKKHBCDVC Direction: Forward Position #: 1 Overlap #: 20 Alignment: VHTYAGBACYDDGRKKASCDVC MSGKKRCGCWDCABTGBBCD-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Reverse Complement MVKBDGCRCHDBRGKKHBCDVC MGGTCAGGGTGACCTRDBHV MVKBVGSDCADBVKGDCCHDVVHV Direction: Forward Position #: 5 Overlap #: 18 Alignment: MVKBDGCRCHDBRGKKHBCDVC-- ----MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Original Motif MVKBVGSDCADBVKGDCCHDVVHV CCCCMAAMCAMCCMCMMMCV MVKBVVCHCAAVVCRVCCHVVVHVV Direction: Forward Position #: 6 Overlap #: 19 Alignment: MVKBVGSDCADBVKGDCCHDVVHV- -----CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif BVDVVVDGGBKGVBTTGDGVBVYVR BTRGGDCARAGGKCA BVDRGGDSRVWGGBBWGDGVBVYVR Direction: Forward Position #: 2 Overlap #: 15 Alignment: BVDVVVDGGBKGVBTTGDGVBVYVR -BTRGGDCARAGGKCA--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Reverse Complement BVDRGGDSRVWGGBBWGDGVBVYVR BAGGYCABHBTGACCKHV BVDRGVVGRHVRBBBTGASCKHBVR Direction: Forward Position #: 6 Overlap #: 18 Alignment: BVDRGGDSRVWGGBBWGDGVBVYVR -----BAGGYCABHBTGACCKHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif BVDRGVVGRHVRBBBTGASCKHBVR RGGBCAAAGKYCA BVDRGVGGDCAAVGBTSASCKHBVR Direction: Forward Position #: 6 Overlap #: 13 Alignment: BVDRGVVGRHVRBBBTGASCKHBVR -----RGGBCAAAGKYCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Reverse Complement Original Motif MVBHRGSTSABCBTTGHCCVCMDVB TKKTTTGTTTTTTT MVTDDDKTSWTYTTTKHCCVCMDVB Direction: Forward Position #: 3 Overlap #: 14 Alignment: MVBHRGSTSABCBTTGHCCVCMDVB --TKKTTTGTTTTTTT--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Tcfcp2l1 Original Motif Reverse Complement MVTDDDKTSWTYTTTKHCCVCMDVB CKGGDTBDMMCTGG CHGGDDDBHVCTKKTTKHCCVCMDVB Direction: Forward Position #: 2 Overlap #: 13 Alignment: -MVTDDDKTSWTYTTTKHCCVCMDVB CKGGDTBDMMCTGG------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 9 Combined Motif Original Motif Original Motif CHGGDDDBHVCTKKTTKHCCVCMDVB CACACAVRCACACA CHGGDDDBHVCTKKTTKHCACMCAVDCACACA Direction: Forward Position #: 19 Overlap #: 8 Alignment: CHGGDDDBHVCTKKTTKHCCVCMDVB------ ------------------CACACAVRCACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 25 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Arnt Esrrb Original Motif Original Motif CACGTG CACGTG CACGTG Direction: Backward Position #: 1 Overlap #: 6 Alignment: CACGTG CACGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Reverse Complement Reverse Complement CACGTG ACCACGTGSTM ACCACGTGSTM Direction: Forward Position #: 3 Overlap #: 6 Alignment: --CACGTG--- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Reverse Complement ACCACGTGSTM DCCACGTGCV DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: ACCACGTGSTM DCCACGTGCV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Mycn Original Motif Reverse Complement DCCACGTGSDM GCCACGTGSD DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: DCCACGTGSDM GCCACGTGSD- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Reverse Complement Original Motif RHSCACGTGGH VBACGTGV VBRCRYGYGGH Direction: Forward Position #: 1 Overlap #: 8 Alignment: RHSCACGTGGH VBACGTGV--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ArntAhr Reverse Complement Reverse Complement DCCMCMMGKBV CACGCM CMCGCMMGKBV Direction: Forward Position #: 1 Overlap #: 6 Alignment: DCCMCMMGKBV CACGCM----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZEB1 Combined Motif Reverse Complement Reverse Complement VBRCRYGCGYG HAGGTG VHASGTGCGYG Direction: Forward Position #: 2 Overlap #: 6 Alignment: VBRCRYGCGYG -HAGGTG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Original Motif VHASGTGCGYG HGCGTGGGCGK HGCRBGKGCGBG Direction: Forward Position #: 2 Overlap #: 10 Alignment: -VHASGTGCGYG HGCGTGGGCGK- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Original Motif CVCGCYCVMGCH BAACGTCCGC BHACGYCCGCGCH Direction: Forward Position #: 2 Overlap #: 9 Alignment: -CVCGCYCVMGCH BAACGTCCGC--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif HGCGCGGKCGTHV GGGGCCCAAGGGGG GGGGCCHRMGSGGGCGTHV Direction: Forward Position #: 7 Overlap #: 8 Alignment: ------HGCGCGGKCGTHV GGGGCCCAAGGGGG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 26 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ArntAhr Egr1 Reverse Complement Reverse Complement CACGCM YCGCCCACGCH CACGCMYCGCC Direction: Backward Position #: 1 Overlap #: 6 Alignment: -----CACGCM YCGCCCACGCH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Original Motif Reverse Complement CACGCMYCGCC VCACGTBV VCACGYHHCGCC Direction: Forward Position #: 2 Overlap #: 7 Alignment: -CACGCMYCGCC VCACGTBV---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 11 Original Motif Original Motif VCACGYHHCGCC CAYACACACACACA CAYACACACACACRYHHCGCC Direction: Forward Position #: 10 Overlap #: 5 Alignment: ---------VCACGYHHCGCC CAYACACACACACA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Esrrb Original Motif Reverse Complement CAYACACACACACRYHHCGCC CACGTG CACRYRCACACACRYHHCGCC Direction: Forward Position #: 1 Overlap #: 6 Alignment: CAYACACACACACRYHHCGCC CACGTG--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Arnt Original Motif Reverse Complement CACRYRCACACACRYHHCGCC CACGTG CACGTRCACACACRYHHCGCC Direction: Forward Position #: 1 Overlap #: 6 Alignment: CACRYRCACACACRYHHCGCC CACGTG--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 9 Original Motif Original Motif CACGTRCACACACRYHHCGCC CACACAVRCACACA CACRYRCACACACAYHHCGCC Direction: Forward Position #: 1 Overlap #: 14 Alignment: CACGTRCACACACRYHHCGCC CACACAVRCACACA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MYCMAX Combined Motif Original Motif Reverse Complement CACRYRCACACACAYHHCGCC ACCACGTGSTM CGCCMMCACRYRBBHCACRYR Direction: Backward Position #: 5 Overlap #: 11 Alignment: CACRYRCACACACAYHHCGCC ------ACCACGTGSTM---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 27 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- E2F1 PLAG1 Original Motif Reverse Complement TTTSGCGC CCCCCTTGGGCCCC CYYYSKYGSGCCCC Direction: Forward Position #: 2 Overlap #: 8 Alignment: -TTTSGCGC----- CCCCCTTGGGCCCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Original Motif GGGGCSCKYSKKMG BTRGGDCARAGGKCA BGRGGSSMRVGGKMR Direction: Forward Position #: 2 Overlap #: 14 Alignment: -GGGGCSCKYSKKMG BTRGGDCARAGGKCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Reverse Complement Reverse Complement MRRCCBMYSSCCMCB TGMYCTTTGBCCK HGRYCTHTGBCCBCB Direction: Forward Position #: 1 Overlap #: 13 Alignment: MRRCCBMYSSCCMCB TGMYCTTTGBCCK-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Original Motif BGBGGBCAHAGKKCH AAAGGTCAAAGGTCAAC VRRGGTCAAAGGTCAAC Direction: Forward Position #: 1 Overlap #: 15 Alignment: BGBGGBCAHAGKKCH-- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Original Motif Reverse Complement VRRGGTCAAAGGTCAAC AKGYYCAAAGRTCA VRDGBTCAAAGGTCAAC Direction: Forward Position #: 2 Overlap #: 14 Alignment: VRRGGTCAAAGGTCAAC -AKGYYCAAAGRTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Reverse Complement Original Motif GTTGACCTTTGABCHKB GSMMCCYARGGKKKC CCTTTGABCHKBGTTGMGTTGACCTTTGA Direction: Backward Position #: 13 Overlap #: 5 Alignment: ----------GTTGACCTTTGABCHKB ------------GSMMCCYARGGKKKC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 28 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Egr1 RREB1 Original Motif Reverse Complement HGCGTGGGCGK BGRRRGRGGRTGRTTYGGGG GGDGSKKGKKYGGBGRRRGR Direction: Backward Position #: 3 Overlap #: 11 Alignment: -------HGCGTGGGCGK-- BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 11 Original Motif Reverse Complement GGDGSKKGKKYGGBGRRRGR TGTGTGTGTGTKTG TGKGTGTGTGKKTGGBGRRRGR Direction: Forward Position #: 3 Overlap #: 12 Alignment: --GGDGSKKGKKYGGBGRRRGR TGTGTGTGTGTKTG-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 9 Combined Motif Reverse Complement Original Motif MCMMMCBCCAYRCACACACYCA CACACAVRCACACA MCMMCMSMCABRCACACACYCA Direction: Forward Position #: 5 Overlap #: 14 Alignment: MCMMMCBCCAYRCACACACYCA ----CACACAVRCACACA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Original Motif Reverse Complement MCMMCMSMCABRCACACACYCA GYRYCCMTKGGYRSC MCMMCMSMCABRCACRCACCCATKGGYRSC Direction: Forward Position #: 16 Overlap #: 7 Alignment: MCMMCMSMCABRCACACACYCA-------- ---------------GYRYCCMTKGGYRSC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Reverse Complement GSMMCCYATGGGTGKGTGKBTGYSYGRRGR VAGGCCBBGGCVBB GSMMCCYAKGSSKBKGYGBBTGYSYGRRGR Direction: Forward Position #: 7 Overlap #: 14 Alignment: GSMMCCYATGGGTGKGTGKBTGYSYGRRGR ------VAGGCCBBGGCVBB---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement GSMMCCYAKGSSKBKGYGBBTGYSYGRRGR MSGKKRCGCWDCABTGBBCD GSMMCCMAGGBVHGSDBSVBTGYBYGRRGR Direction: Forward Position #: 7 Overlap #: 20 Alignment: GSMMCCYAKGSSKBKGYGBBTGYSYGRRGR ------MSGKKRCGCWDCABTGBBCD---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Original Motif Reverse Complement GSMMCCMAGGBVHGSDBSVBTGYBYGRRGR MGCCCCCTGMCA VGCCCCCWGVCAHGSDBSVBTGYBYGRRGR Direction: Forward Position #: 1 Overlap #: 12 Alignment: GSMMCCMAGGBVHGSDBSVBTGYBYGRRGR MGCCCCCTGMCA------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif VGCCCCCWGVCAHGSDBSVBTGYBYGRRGR RGGBCAAAGKYCA VGCCCCVDGBCAHRSKBCVBTGYBYGRRGR Direction: Forward Position #: 7 Overlap #: 13 Alignment: VGCCCCCWGVCAHGSDBSVBTGYBYGRRGR ------RGGBCAAAGKYCA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Reverse Complement Original Motif MCMMCKBMCABBGVYSKHTGBCHVGGGGCV CCCCKCCCCC CCCCBBCCCMBBGVYSKHTGBCHVGGGGCV Direction: Forward Position #: 1 Overlap #: 10 Alignment: MCMMCKBMCABBGVYSKHTGBCHVGGGGCV CCCCKCCCCC-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Original Motif Reverse Complement CCCCBBCCCMBBGVYSKHTGBCHVGGGGCV GCCYCMCCCD SCCYCHCCCHBBGVYSKHTGBCHVGGGGCV Direction: Forward Position #: 1 Overlap #: 10 Alignment: CCCCBBCCCMBBGVYSKHTGBCHVGGGGCV GCCYCMCCCD-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 29 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Pax5 Reverse Complement Reverse Complement MGGTCAGGGTGACCTRDBHV MSGKKRCGCWDCABTGBBCD MGGTBAVGCTKVMCTGBBMD Direction: Backward Position #: 1 Overlap #: 20 Alignment: MGGTCAGGGTGACCTRDBHV MSGKKRCGCWDCABTGBBCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif HRBBCAGRVYAGCVTBACCY HWDAGHACRHHVTGTHCCHVMV HDHVSARSRYHSYGTDMCVBMV Direction: Forward Position #: 1 Overlap #: 20 Alignment: HRBBCAGRVYAGCVTBACCY-- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Original Motif HDHVSARSRYHSYGTDMCVBMV CCCCMAAMCAMCCMCMMMCV HDHVSMMCAMAVCRHCCCCHMMCV Direction: Forward Position #: 5 Overlap #: 18 Alignment: HDHVSARSRYHSYGTDMCVBMV-- ----CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement BGRRDGGGGHKGVTYTGRRSBHDH BAGGYCABHBTGACCKHV BGRRDVRGGHBRVHBTGASCKHDH Direction: Forward Position #: 6 Overlap #: 18 Alignment: BGRRDGGGGHKGVTYTGRRSBHDH -----BAGGYCABHBTGACCKHV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Reverse Complement BGRRDVRGGHBRVHBTGASCKHDH TGACCTCKVVBTGAYCK BGRRTGABSTVDVBBTGACCKHDH Direction: Forward Position #: 5 Overlap #: 17 Alignment: BGRRDVRGGHBRVHBTGASCKHDH ----TGACCTCKVVBTGAYCK--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif HHHRGGTCAVBVHVASBTCAMMCB TTCAGCACCATGGACAGCKCC THCAGSAYCAHGGASAGCKCHMMCB Direction: Forward Position #: 2 Overlap #: 20 Alignment: -HHHRGGTCAVBVHVASBTCAMMCB TTCAGCACCATGGACAGCKCC---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Reverse Complement Reverse Complement BGRRDGRGCTSTCCHTGKTSCTGHA TGAACKCBWTGACCC TGAACKMBHTGACCMTGKTSCTGHA Direction: Forward Position #: 1 Overlap #: 15 Alignment: BGRRDGRGCTSTCCHTGKTSCTGHA TGAACKCBWTGACCC---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Reverse Complement THCAGSAYCARGGTCADBRYGTTCA TGRCCTKTGHCCKAB THCAKGRCCWKKGHCMKVVYGTTCA Direction: Forward Position #: 5 Overlap #: 15 Alignment: THCAGSAYCARGGTCADBRYGTTCA ----TGRCCTKTGHCCKAB------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Reverse Complement Reverse Complement TGAACKVBYYGHCRYWGGKCRTGHA VAGGCCBBGGCVBB VWGGMCBBKBYGVCRYWGGKCRTGHA Direction: Forward Position #: 2 Overlap #: 13 Alignment: -TGAACKVBYYGHCRYWGGKCRTGHA VAGGCCBBGGCVBB------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Reverse Complement VWGGMCBBKBYGVCRYWGGKCRTGHA GYRYCCMTKGGYRSC GBRBSCCTBGGYRSCRYWGGKCRTGHA Direction: Forward Position #: 2 Overlap #: 14 Alignment: -VWGGMCBBKBYGVCRYWGGKCRTGHA GYRYCCMTKGGYRSC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 30 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Ar Reverse Complement Original Motif BAGGYCABHBTGACCKHV HWDAGHACRHHVTGTHCCHVMV HWHAGDWCAHHVTGWCCBHVMV Direction: Forward Position #: 3 Overlap #: 18 Alignment: --BAGGYCABHBTGACCKHV-- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif VRVHBGGWCAVDDTGWHCTHWH DGVBCABTGDWGCGKRRCSR DRVDBRVTSADGBKGDVCBDWH Direction: Forward Position #: 1 Overlap #: 20 Alignment: VRVHBGGWCAVDDTGWHCTHWH DGVBCABTGDWGCGKRRCSR-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Reverse Complement DRVDBRVTSADGBKGDVCBDWH BGRRRGRGGRTGRTTYGGGG BGRDRGDVGRTGRHKYGGGRCBDWH Direction: Forward Position #: 4 Overlap #: 17 Alignment: ---DRVDBRVTSADGBKGDVCBDWH BGRRRGRGGRTGRTTYGGGG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif HWHVGMCCCMRHKCAMCVHCMHMCB TTCAGCACCATGGACAGCKCC HTCAGCACCHDGGMMASCDCCHMCB Direction: Forward Position #: 1 Overlap #: 21 Alignment: HWHVGMCCCMRHKCAMCVHCMHMCB TTCAGCACCATGGACAGCKCC---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Reverse Complement BGRDGGHGSTRYCCDHGGTGCTGAH MGGTCAGGGTGACCTRDBHV HGGDSRVGSTGHCCDDGGHVCTGAH Direction: Forward Position #: 1 Overlap #: 20 Alignment: BGRDGGHGSTRYCCDHGGTGCTGAH MGGTCAGGGTGACCTRDBHV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Original Motif HGGDSRVGSTGHCCDDGGHVCTGAH RGKTCABVVRGAGGTCA VGGTCABVVDGASBTBRGHVCTGAH Direction: Forward Position #: 1 Overlap #: 17 Alignment: HGGDSRVGSTGHCCDDGGHVCTGAH RGKTCABVVRGAGGTCA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Reverse Complement HTCAGVHCKBABSTCDVVBTGACCB TGRCCTKTGHCCKAB HTCAKVVCBKDTSBCHBVBTGACCB Direction: Forward Position #: 5 Overlap #: 15 Alignment: HTCAGVHCKBABSTCDVVBTGACCB ----TGRCCTKTGHCCKAB------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Reverse Complement HTCAKVVCBKDTSBCHBVBTGACCB VAGGCCBBGGCVBB HTCAKVASGCCBBKSCBVBTGACCB Direction: Forward Position #: 6 Overlap #: 14 Alignment: HTCAKVVCBKDTSBCHBVBTGACCB -----VAGGCCBBGGCVBB------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Reverse Complement VGGTCABVBGSYBVGGCSTVYTGAH AKGYYCAAAGRTCA VGGTBMAAVGRTCAGGCSTVYTGAH Direction: Forward Position #: 1 Overlap #: 14 Alignment: VGGTCABVBGSYBVGGCSTVYTGAH AKGYYCAAAGRTCA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Reverse Complement Reverse Complement HTCAKVASGCCTGAMCBTTRBACCB CKGGDTBDMMCTGG HTCAKCDGGBBTGAMCTKGRBACCB Direction: Forward Position #: 6 Overlap #: 14 Alignment: HTCAKVASGCCTGAMCBTTRBACCB -----CKGGDTBDMMCTGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 31 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Esrrb Arnt Original Motif Original Motif CACGTG CACGTG CACGTG Direction: Backward Position #: 1 Overlap #: 6 Alignment: CACGTG CACGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Reverse Complement Reverse Complement CACGTG ACCACGTGSTM ACCACGTGSTM Direction: Forward Position #: 3 Overlap #: 6 Alignment: --CACGTG--- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Reverse Complement ACCACGTGSTM DCCACGTGCV DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: ACCACGTGSTM DCCACGTGCV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Mycn Original Motif Reverse Complement DCCACGTGSDM GCCACGTGSD DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: DCCACGTGSDM GCCACGTGSD- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Reverse Complement Original Motif RHSCACGTGGH VBACGTGV VBRCRYGYGGH Direction: Forward Position #: 1 Overlap #: 8 Alignment: RHSCACGTGGH VBACGTGV--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ArntAhr Reverse Complement Reverse Complement DCCMCMMGKBV CACGCM CMCGCMMGKBV Direction: Forward Position #: 1 Overlap #: 6 Alignment: DCCMCMMGKBV CACGCM----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZEB1 Combined Motif Reverse Complement Reverse Complement VBRCRYGCGYG HAGGTG VHASGTGCGYG Direction: Forward Position #: 2 Overlap #: 6 Alignment: VBRCRYGCGYG -HAGGTG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Original Motif VHASGTGCGYG HGCGTGGGCGK HGCRBGKGCGBG Direction: Forward Position #: 2 Overlap #: 10 Alignment: -VHASGTGCGYG HGCGTGGGCGK- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Original Motif CVCGCYCVMGCH BAACGTCCGC BHACGYCCGCGCH Direction: Forward Position #: 2 Overlap #: 9 Alignment: -CVCGCYCVMGCH BAACGTCCGC--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif HGCGCGGKCGTHV GGGGCCCAAGGGGG GGGGCCHRMGSGGGCGTHV Direction: Forward Position #: 7 Overlap #: 8 Alignment: ------HGCGCGGKCGTHV GGGGCCCAAGGGGG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 32 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- EWSR1-FLI1 NR1H2RXRA Original Motif Original Motif GGAAGGAAGGAAGGAAGG AAAGGTCAAAGGTCAAC TCAACRAAGGWMRRARGGGAAGG Direction: Backward Position #: 6 Overlap #: 12 Alignment: GGAAGGAAGGAAGGAAGG----- ------AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Original Motif Reverse Complement TCAACRAAGGWMRRARGGGAAGG AAAAAAACAAARRA TMAAVAAAGRAARRARGGGAAGG Direction: Forward Position #: 2 Overlap #: 14 Alignment: TCAACRAAGGWMRRARGGGAAGG -AAAAAAACAAARRA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement TMAAVAAAGRAARRARGGGAAGG BGRRRGRGGRTGRTTYGGGG TMAAVAAAGRAARRARGGGAAGGGGRTGRTTYGGGG Direction: Forward Position #: 17 Overlap #: 7 Alignment: TMAAVAAAGRAARRARGGGAAGG------------- ----------------BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Reverse Complement Original Motif CCCCMAAMCAMCCCCTTCCCKTKKTTKCTTTBTTRA CCCCKCCCCC CCCCVMMCCMMCCCCTTCCCKTKKTTKCTTTBTTRA Direction: Forward Position #: 1 Overlap #: 10 Alignment: CCCCMAAMCAMCCCCTTCCCKTKKTTKCTTTBTTRA CCCCKCCCCC-------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MIZF Combined Motif Reverse Complement Reverse Complement TMAAVAAAGRAARRAYGGGAAGGGGRYGGRRBGGGG GCGGACGTTV BGGGGGSGGACGKDVTMAAVAAAGRAARRAYGGGAA Direction: Backward Position #: 6 Overlap #: 10 Alignment: TMAAVAAAGRAARRAYGGGAAGGGGRYGGRRBGGGG ---------------------GCGGACGTTV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 33 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HIF1AARNT Mycn Original Motif Reverse Complement VBACGTGV GCCACGTGSD DSCACGTGSG Direction: Backward Position #: 2 Overlap #: 8 Alignment: -VBACGTGV- GCCACGTGSD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Reverse Complement Original Motif CSCACGTGSH VGCACGTGGH CSCACGTGGH Direction: Forward Position #: 1 Overlap #: 10 Alignment: CSCACGTGSH VGCACGTGGH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Reverse Complement Reverse Complement DCCACGTGSG ACCACGTGSTM VCCACGTGSKM Direction: Forward Position #: 1 Overlap #: 10 Alignment: DCCACGTGSG- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Reverse Complement RRSCACGTGGB GCGGACGTTV GCGSACGTKGB Direction: Forward Position #: 1 Overlap #: 10 Alignment: RRSCACGTGGB GCGGACGTTV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Ar Reverse Complement Reverse Complement VCYACGTSCGC VRVDGGHACAVDDKGTHCTDWH VVHASGTVCVVDDKGTHCTDWH Direction: Forward Position #: 1 Overlap #: 11 Alignment: VCYACGTSCGC----------- VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif VVHASGTVCVVDDKGTHCTDWH DGVBCABTGDWGCGKRRCSR VVHAVGHDCAVBGDGKHSTDDCSR Direction: Forward Position #: 5 Overlap #: 18 Alignment: VVHASGTVCVVDDKGTHCTDWH-- ----DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement VVHAVGHDCAVBGDGKHSTDDCSR BGRRRGRGGRTGRTTYGGGG VVHHSGDDSRVGGTGKYBTGRSGR Direction: Forward Position #: 4 Overlap #: 20 Alignment: VVHAVGHDCAVBGDGKHSTDDCSR ---BGRRRGRGGRTGRTTYGGGG- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_5-13 Combined Motif Original Motif Original Motif VVHHSGDDSRVGGTGKYBTGRSGR BKAGGGGDAD VVHHSGDAGGGGGWRKYBTGRSGR Direction: Forward Position #: 6 Overlap #: 10 Alignment: VVHHSGDDSRVGGTGKYBTGRSGR -----BKAGGGGDAD--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif VVHHSGDAGGGGGWRKYBTGRSGR VHRGGTCABDBTGMCCTB VDVDGKCABGGKGHVBYBTGRSGR Direction: Forward Position #: 1 Overlap #: 18 Alignment: VVHHSGDAGGGGGWRKYBTGRSGR VHRGGTCABDBTGMCCTB------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Reverse Complement VDVDGKCABGGKGHVBYBTGRSGR TGACCTCKVVBTGAYCK TVABSTCWVVBTGABCTBTGRSGR Direction: Forward Position #: 1 Overlap #: 17 Alignment: VDVDGKCABGGKGHVBYBTGRSGR TGACCTCKVVBTGAYCK------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 34 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A PPARGRXRA Reverse Complement Reverse Complement TGMYCTTTGBCCK TGRCCTKTGHCCKAB ABTGACCTTTGBCCK Direction: Backward Position #: 3 Overlap #: 13 Alignment: TGMYCTTTGBCCK-- TGRCCTKTGHCCKAB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Reverse Complement RGGBCAAAGGTCABT AKGYYCAAAGRTCA ARGBBCAAAGGTCABT Direction: Forward Position #: 2 Overlap #: 13 Alignment: -RGGBCAAAGGTCABT AKGYYCAAAGRTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Reverse Complement ABTGACCTTTGVBCMT GTTGACCTTTGACCTTT VBTGACCTTTGACCHTT Direction: Forward Position #: 1 Overlap #: 16 Alignment: ABTGACCTTTGVBCMT- GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Reverse Complement Original Motif AAHGGTCAAAGGTCAVV RGKTCABVVRGAGGTCA RGDWCRBBCARAGGTCAVV Direction: Forward Position #: 3 Overlap #: 15 Alignment: --AAHGGTCAAAGGTCAVV RGKTCABVVRGAGGTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif VBTGACCTKTGVBKGWDCK DGVBCABTGDWGCGKRRCSR VBTGABCWBTGVHGVRKCDCSR Direction: Forward Position #: 3 Overlap #: 17 Alignment: VBTGACCTKTGVBKGWDCK--- --DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement MSGHGRMVCHBCAVWGBTCAVV BAGGYCABHBTGACCKHV MSGMGRHCMHBBWGASBKHDVV Direction: Forward Position #: 3 Overlap #: 18 Alignment: MSGHGRMVCHBCAVWGBTCAVV --BAGGYCABHBTGACCKHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement MSGMGRHCMHBBWGASBKHDVV VRVDGGHACAVDDKGTHCTDWH MSGMGRHVVGHHCVVBBKGTHCTDWH Direction: Forward Position #: 5 Overlap #: 18 Alignment: MSGMGRHCMHBBWGASBKHDVV---- ----VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif HWDAGHACRBBBBGHHCVVDMCYCSR VDBHMAGGTCACCCTGACCY HWDAGHDBVHVKGKCACVVTVMCCBR Direction: Forward Position #: 6 Overlap #: 20 Alignment: HWDAGHACRBBBBGHHCVVDMCYCSR -----VDBHMAGGTCACCCTGACCY- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif MBGGYVAVVGTGRCYBDBBDHCTDWH GGGGCCCAAGGGGG GVGGSCCAVGGKGGCYBDBBDHCTDWH Direction: Forward Position #: 2 Overlap #: 13 Alignment: -MBGGYVAVVGTGRCYBDBBDHCTDWH GGGGCCCAAGGGGG------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif HWDAGHDBVHVKGCCYCCBTGGSCCVC TTCAGCACCATGGACAGCKCC HTHAGBACCHHGGMCMSCBHVGSCCVC Direction: Forward Position #: 1 Overlap #: 21 Alignment: HWDAGHDBVHVKGCCYCCBTGGSCCVC TTCAGCACCATGGACAGCKCC------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 35 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 PPARGRXRA Original Motif Original Motif TGYCAGGGGGCR BTRGGDCARAGGKCA BTRKGBCAGRGGKCA Direction: Forward Position #: 4 Overlap #: 12 Alignment: ---TGYCAGGGGGCR BTRGGDCARAGGKCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement BTRKGBCAGRGGKCA BGRRRGRGGRTGRTTYGGGG BTDGGDVRRRGGTSRTTYGGGG Direction: Forward Position #: 3 Overlap #: 13 Alignment: BTRKGBCAGRGGKCA------- --BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Original Motif BTDGGDVRRRGGTSRTTYGGGG GSMMCCYARGGKKKC GBVVSCHARGGGKSVTTYGGGG Direction: Forward Position #: 1 Overlap #: 15 Alignment: BTDGGDVRRRGGTSRTTYGGGG GSMMCCYARGGKKKC------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Original Motif GBVVSCHARGGGKSVTTYGGGG RGGBCAAAGKYCA RGVBCMHAGGGBDSVTTYGGGG Direction: Forward Position #: 1 Overlap #: 13 Alignment: GBVVSCHARGGGKSVTTYGGGG RGGBCAAAGKYCA--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Original Motif RGVBCMHAGGGBDSVTTYGGGG VDBHMAGGTCACCCTGACCY VDVBVVSRDMRBBBTGMYYYGGGG Direction: Forward Position #: 3 Overlap #: 18 Alignment: --RGVBCMHAGGGBDSVTTYGGGG VDBHMAGGTCACCCTGACCY---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif VDVBVVSRDMRBBBTGMYYYGGGG DGVBCABTGDWGCGKRRCSR DRVBHABBDVRGCGTGVCBDGGGG Direction: Forward Position #: 1 Overlap #: 20 Alignment: VDVBVVSRDMRBBBTGMYYYGGGG DGVBCABTGDWGCGKRRCSR---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif DRVBHABBDVRGCGTGVCBDGGGG BBVGCCBVGGCCTV DRVBVDSYBVGGCCTGVCBDGGGG Direction: Forward Position #: 3 Overlap #: 14 Alignment: DRVBHABBDVRGCGTGVCBDGGGG --BBVGCCBVGGCCTV-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 11 Combined Motif Original Motif Reverse Complement DRVBVDSYBVGGCCTGVCBDGGGG TGTGTGTGTGTKTG DRVBVDSYBVGGCCTGVCBTGKGKGTGTGTKTG Direction: Forward Position #: 20 Overlap #: 5 Alignment: DRVBVDSYBVGGCCTGVCBDGGGG--------- -------------------TGTGTGTGTGTKTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA Combined Motif Original Motif Reverse Complement DRVBVDSYBVGGCCTGVCBTGKGKGTGTGTKTG GTTGACCTTTGACCTTT DRVBVDSYBVGGCCTGVCBTGKGKGTGTGKKTGACCTTTGACCTTT Direction: Forward Position #: 30 Overlap #: 4 Alignment: DRVBVDSYBVGGCCTGVCBTGKGKGTGTGTKTG------------- -----------------------------GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Reverse Complement Reverse Complement AAAGGTCAAAGGTCARRCACACRCRCABGBCAGGCCBBKSHVBVMH AKGYYCAAAGRTCA AARGGTCAAAGGTCARRCACACRCRCABGBCAGGCCBBKSHVBVMH Direction: Forward Position #: 2 Overlap #: 14 Alignment: AAAGGTCAAAGGTCARRCACACRCRCABGBCAGGCCBBKSHVBVMH -AKGYYCAAAGRTCA------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 36 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 RREB1 Original Motif Reverse Complement DGGGYGKGGC BGRRRGRGGRTGRTTYGGGG TGGKTKGGGVBGRRRGRGGR Direction: Backward Position #: 1 Overlap #: 10 Alignment: ----------DGGGYGKGGC BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Original Motif Reverse Complement TGGKTKGGGVBGRRRGRGGR VAGGCCBBGGCVBB BRGGYCKGGSBSVVRGRGGR Direction: Forward Position #: 1 Overlap #: 14 Alignment: TGGKTKGGGVBGRRRGRGGR VAGGCCBBGGCVBB------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Original Motif Reverse Complement BRGGYCKGGSBSVVRGRGGR GGGGGYGGGG BRGGBYGGGGBSVVRGRGGR Direction: Forward Position #: 1 Overlap #: 10 Alignment: BRGGYCKGGSBSVVRGRGGR GGGGGYGGGG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 11 Combined Motif Reverse Complement Original Motif MCCMCMVVSBCCCCKBCCMB CAYACACACACACA VVSBCCCCKBCCMBCMCACAMCCMCMVVSBCCCC Direction: Backward Position #: 15 Overlap #: 6 Alignment: --------MCCMCMVVSBCCCCKBCCMB --------------CAYACACACACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 37 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MIZF MYCMAX Original Motif Reverse Complement BAACGTCCGC ACCACGTGSTM ACMACGTSCKC Direction: Forward Position #: 2 Overlap #: 10 Alignment: -BAACGTCCGC ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Reverse Complement Reverse Complement GYGSACGTRGT BAGGYCABHBTGACCKHV VMGGACRTVBTGACCKHV Direction: Forward Position #: 1 Overlap #: 11 Alignment: GYGSACGTRGT------- BAGGYCABHBTGACCKHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Original Motif VHRGGTCABVAMGTCCRV VDBHMAGGTCACCCTGACCY VDBHHRGGTCABHMHGWCCDV Direction: Forward Position #: 4 Overlap #: 17 Alignment: ---VHRGGTCABVAMGTCCRV VDBHMAGGTCACCCTGACCY- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif VDGGWCHRDBTGACCKHDBHV HWDAGHACRHHVTGTHCCHVMV VDGGHHHRGVWSACCBYGTHCCHVMV Direction: Forward Position #: 5 Overlap #: 17 Alignment: VDGGWCHRDBTGACCKHDBHV----- ----HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA Combined Motif Reverse Complement Reverse Complement VRVDGGHACMBGGTSWBCKHDHCCDV GTTGACCTTTGACCTTT VRVDGGHACMBGGTSWBSTTGACCTTTGACCTTT Direction: Forward Position #: 18 Overlap #: 9 Alignment: VRVDGGHACMBGGTSWBCKHDHCCDV-------- -----------------GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif VRVDGGHACMBGGTSWBSTTGACCTTTGACCTTT TTCAGCACCATGGACAGCKCC BDCAGSACCABGGWSAGCKHSACCTTTGACCTTT Direction: Forward Position #: 1 Overlap #: 21 Alignment: VRVDGGHACMBGGTSWBSTTGACCTTTGACCTTT TTCAGCACCATGGACAGCKCC------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Pax5 Original Motif Original Motif BDCAGSACCABGGWSAGCKHSACCTTTGACCTTT DGVBCABTGDWGCGKRRCSR DGDDCAGBVVHGHGKRVMSVKHSACCTTTGACCTTT Direction: Forward Position #: 3 Overlap #: 18 Alignment: --BDCAGSACCABGGWSAGCKHSACCTTTGACCTTT DGVBCABTGDWGCGKRRCSR---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Myc Combined Motif Original Motif Reverse Complement DGDDCAGBVVHGHGKRVMSVKHSACCTTTGACCTTT DCCACGTGCV DGDBCACGTGVRHGKRVMSVKHSACCTTTGACCTTT Direction: Forward Position #: 3 Overlap #: 10 Alignment: DGDDCAGBVVHGHGKRVMSVKHSACCTTTGACCTTT --DCCACGTGCV------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Reverse Complement DGDBCACGTGVRHGKRVMSVKHSACCTTTGACCTTT YCGCCCACGCH YCGCCCACGHVVRHGKRVMSVKHSACCTTTGACCTTT Direction: Forward Position #: 2 Overlap #: 10 Alignment: -DGDBCACGTGVRHGKRVMSVKHSACCTTTGACCTTT YCGCCCACGCH-------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn Combined Motif Original Motif Reverse Complement YCGCCCACGHVVRHGKRVMSVKHSACCTTTGACCTTT GCCACGTGSD YVSCMCRYGBVVRHGKRVMSVKHSACCTTTGACCTTT Direction: Forward Position #: 2 Overlap #: 10 Alignment: YCGCCCACGHVVRHGKRVMSVKHSACCTTTGACCTTT -GCCACGTGSD-------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 38 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Myc Mycn Reverse Complement Reverse Complement DCCACGTGCV GCCACGTGSD GCCACGTGSV Direction: Forward Position #: 1 Overlap #: 10 Alignment: DCCACGTGCV GCCACGTGSD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Original Motif Reverse Complement GCCACGTGSV ACCACGTGSTM DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: GCCACGTGSV- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Original Motif RDSCACGTGGD TGYCAGGGGGCR KGBCASGKGGHR Direction: Forward Position #: 1 Overlap #: 11 Alignment: RDSCACGTGGD- TGYCAGGGGGCR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Reverse Complement MDCCYCSTGBCR GCCYCMCCCD GCCYCHCCYRBCR Direction: Forward Position #: 2 Overlap #: 9 Alignment: -MDCCYCSTGBCR GCCYCMCCCD--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Reverse Complement Original Motif KGBMKGGDGKGGC BBVGCCBVGGCCTV BBDGSCKSGGSSTGC Direction: Forward Position #: 3 Overlap #: 12 Alignment: --KGBMKGGDGKGGC BBVGCCBVGGCCTV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Original Motif Original Motif BBDGSCKSGGSSTGC GGGGCCCAAGGGGG GGGGSCCDVGGGGKGC Direction: Forward Position #: 2 Overlap #: 13 Alignment: -BBDGSCKSGGSSTGC GGGGCCCAAGGGGG-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Original Motif GGGGSCCDVGGGGKGC GSMMCCYARGGKKKC GSVVCCYWRGGGKKVC Direction: Forward Position #: 1 Overlap #: 15 Alignment: GGGGSCCDVGGGGKGC GSMMCCYARGGKKKC- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Reverse Complement Reverse Complement GVYYCCCKWKGGVVSC TGMYCTTTGBCCK TGVYCYYYGDBSGVVSC Direction: Forward Position #: 2 Overlap #: 12 Alignment: -GVYYCCCKWKGGVVSC TGMYCTTTGBCCK---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif GSVVCSBDCKKMGKBCA VDBHMAGGTCACCCTGACCY GSVVBSBVHGGHSDBCVTGACCY Direction: Forward Position #: 4 Overlap #: 14 Alignment: GSVVCSBDCKKMGKBCA------ ---VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement GSVVBSBVHGGHSDBCVTGACCY VRVDGGHACAVDDKGTHCTDWH GSVVBBBGHRSHSDBBGTBMYHHH Direction: Forward Position #: 3 Overlap #: 21 Alignment: GSVVBSBVHGGHSDBCVTGACCY- --VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 39 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MYCMAX RREB1 Reverse Complement Original Motif ACCACGTGSTM CCCCMAAMCAMCCMCMMMCV CCCCMMACSWSCHMCMMMCV Direction: Forward Position #: 4 Overlap #: 11 Alignment: ---ACCACGTGSTM------ CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Reverse Complement BGRRRGRDGSWSGTRRGGGG VRVDGGHACAVDDKGTHCTDWH BGRRDGVDGGWVSWRRDKGKHCTDWH Direction: Forward Position #: 5 Overlap #: 16 Alignment: BGRRRGRDGSWSGTRRGGGG------ ----VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Reverse Complement Reverse Complement HWDAGHRCYHMMWSBWCCHVCHMMCB GYRYCCMTKGGYRSC HWDAGHRCCCMHDGGHVSCVCHMMCB Direction: Forward Position #: 5 Overlap #: 15 Alignment: HWDAGHRCYHMMWSBWCCHVCHMMCB ----GYRYCCMTKGGYRSC------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Reverse Complement HWDAGHRCCCMHDGGHVSCVCHMMCB CCCCCTTGGGCCCC HWDAGCVCCCYWDGGCCCCVCHMMCB Direction: Forward Position #: 6 Overlap #: 14 Alignment: HWDAGHRCCCMHDGGHVSCVCHMMCB -----CCCCCTTGGGCCCC------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Original Motif BGRRDGVGGGGCCHWKGGGVGCTDWH TGYCAGGGGGCR TGDVDGGGGGBVCHWKGGGVGCTDWH Direction: Forward Position #: 1 Overlap #: 12 Alignment: BGRRDGVGGGGCCHWKGGGVGCTDWH TGYCAGGGGGCR-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif HWDAGCVCCCYWDGVBCCCCCDVHCA TTCAGCACCATGGACAGCKCC HTHAGCACCMYKGRCASCBCCDVHCA Direction: Forward Position #: 1 Overlap #: 21 Alignment: HWDAGCVCCCYWDGVBCCCCCDVHCA TTCAGCACCATGGACAGCKCC----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif HTHAGCACCMYKGRCASCBCCDVHCA VHRGGTCABDBTGMCCTB HWVRGYCMCVBKGVCMBCBCCDVHCA Direction: Forward Position #: 1 Overlap #: 18 Alignment: HTHAGCACCMYKGRCASCBCCDVHCA VHRGGTCABDBTGMCCTB-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Reverse Complement TGDVDGGBGVRGBCRVVGYGMCMBWD MGGTCAGGGTGACCTRDBHV HGGHVRGGGDGRCCDVDBYVMCMBWD Direction: Forward Position #: 1 Overlap #: 20 Alignment: TGDVDGGBGVRGBCRVVGYGMCMBWD MGGTCAGGGTGACCTRDBHV------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Original Motif HGGHVRGGGDGRCCDVDBYVMCMBWD RGKTCABVVRGAGGTCA RGKTSRBVRRGRGGDCMDVDBYVMCMBWD Direction: Forward Position #: 4 Overlap #: 14 Alignment: ---HGGHVRGGGDGRCCDVDBYVMCMBWD RGKTCABVVRGAGGTCA------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Reverse Complement Reverse Complement HWVRGYVKBHVDYGDCCKCMMVVKSAYCK VAGGCCBBGGCVBB VAGGSCBBBSVVBSDCCKCMMVVKSAYCK Direction: Forward Position #: 1 Overlap #: 14 Alignment: HWVRGYVKBHVDYGDCCKCMMVVKSAYCK VAGGCCBBGGCVBB--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 40 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn Myc Reverse Complement Reverse Complement GCCACGTGSD DCCACGTGCV GCCACGTGSV Direction: Forward Position #: 1 Overlap #: 10 Alignment: GCCACGTGSD DCCACGTGCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Original Motif Reverse Complement GCCACGTGSV ACCACGTGSTM DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: GCCACGTGSV- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Original Motif RDSCACGTGGD TGYCAGGGGGCR KGBCASGKGGHR Direction: Forward Position #: 1 Overlap #: 11 Alignment: RDSCACGTGGD- TGYCAGGGGGCR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Reverse Complement MDCCYCSTGBCR GCCYCMCCCD GCCYCHCCYRBCR Direction: Forward Position #: 2 Overlap #: 9 Alignment: -MDCCYCSTGBCR GCCYCMCCCD--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif GCCYCHCCYRBCR VDBHMAGGTCACCCTGACCY GCVBCHCVBGBCACCCTGACCY Direction: Forward Position #: 3 Overlap #: 11 Alignment: GCCYCHCCYRBCR--------- --VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Original Motif Original Motif GCVBCHCVBGBCACCCTGACCY BBVGCCBVGGCCTV GCVBCCBVGGCCWVCCTGACCY Direction: Forward Position #: 1 Overlap #: 14 Alignment: GCVBCHCVBGBCACCCTGACCY BBVGCCBVGGCCTV-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Original Motif Reverse Complement GCVBCCBVGGCCWVCCTGACCY CCCCCTTGGGCCCC CCCCCYHVGGCCHCCCTGACCY Direction: Forward Position #: 1 Overlap #: 14 Alignment: GCVBCCBVGGCCWVCCTGACCY CCCCCTTGGGCCCC-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Reverse Complement CCCCCYHVGGCCHCCCTGACCY TGMYCTTTGBCCK BSMCCTTDGGCCBCCCTGACCY Direction: Forward Position #: 1 Overlap #: 13 Alignment: CCCCCYHVGGCCHCCCTGACCY TGMYCTTTGBCCK--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Reverse Complement BSMCCTTDGGCCBCCCTGACCY TGRCCTKTGHCCKAB TSVCCTTTGBCCBMBCTGACCY Direction: Forward Position #: 1 Overlap #: 15 Alignment: BSMCCTTDGGCCBCCCTGACCY TGRCCTKTGHCCKAB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement MGGTCAGBRVGGBCAAAGGBSA BAGGYCABHBTGACCKHV MGGTCAGGDVRBBCWGASSKBV Direction: Forward Position #: 5 Overlap #: 18 Alignment: MGGTCAGBRVGGBCAAAGGBSA ----BAGGYCABHBTGACCKHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 41 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_5-13 INSM1 Original Motif Original Motif BKAGGGGDAD TGYCAGGGGGCR TGBBAGGGGGHR Direction: Forward Position #: 3 Overlap #: 10 Alignment: --BKAGGGGDAD TGYCAGGGGGCR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif TGBBAGGGGGHR DGVBCABTGDWGCGKRRCSR TGBBMRGKGDHGCGKRRCSR Direction: Forward Position #: 1 Overlap #: 12 Alignment: TGBBAGGGGGHR-------- DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Original Motif TGBBMRGKGDHGCGKRRCSR BTRGGDCARAGGKCA TGBBVDRGGDVRVRGGDCVR Direction: Forward Position #: 5 Overlap #: 15 Alignment: TGBBMRGKGDHGCGKRRCSR ----BTRGGDCARAGGKCA- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Reverse Complement TGBBVDRGGDVRVRGGDCVR GYRYCCMTKGGYRSC GBRYCCHDKGGYRSVGGDCVR Direction: Forward Position #: 2 Overlap #: 14 Alignment: -TGBBVDRGGDVRVRGGDCVR GYRYCCMTKGGYRSC------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement GBRYCCHDKGGYRSVGGDCVR BGRRRGRGGRTGRTTYGGGG GBRYYSDDGGGVGRTGRTYHGGGG Direction: Forward Position #: 5 Overlap #: 17 Alignment: GBRYCCHDKGGYRSVGGDCVR--- ----BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Original Motif GBRYYSDDGGGVGRTGRTYHGGGG RGGBCAAAGKYCA RGGBCAAAGGBBRRTGRTYHGGGG Direction: Forward Position #: 1 Overlap #: 13 Alignment: GBRYYSDDGGGVGRTGRTYHGGGG RGGBCAAAGKYCA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Original Motif RGGBCAAAGGBBRRTGRTYHGGGG RGKTCABVVRGAGGTCA RGGTCADVGRVVGGTSRTYHGGGG Direction: Forward Position #: 1 Overlap #: 17 Alignment: RGGBCAAAGGBBRRTGRTYHGGGG RGKTCABVVRGAGGTCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif CCCCHKAKSACCBVMCBDTGACCM HWDAGHACRHHVTGTHCCHVMV CCHMAGAWCAHCBHGYHCYBVMCM Direction: Forward Position #: 2 Overlap #: 22 Alignment: CCCCHKAKSACCBVMCBDTGACCM -HWDAGHACRHHVTGTHCCHVMV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Original Motif RGRBBMGHMCHBGDTGWTCTRDGG VDBHMAGGTCACCCTGACCY RDVBHAGGHCABVBTGWCCTRDGG Direction: Forward Position #: 1 Overlap #: 20 Alignment: RGRBBMGHMCHBGDTGWTCTRDGG VDBHMAGGTCACCCTGACCY---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Original Motif Original Motif RDVBHAGGHCABVBTGWCCTRDGG CCCCKCCCCC RDVCCCSBYCHCCBTGWCCTRDGG Direction: Forward Position #: 4 Overlap #: 10 Alignment: RDVBHAGGHCABVBTGWCCTRDGG ---CCCCKCCCCC----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 42 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NFKB1 Tcfcp2l1 Original Motif Reverse Complement GGGGRTTCCCC CKGGDTBDMMCTGG TGGSGGGDTBBCCC Direction: Backward Position #: 4 Overlap #: 11 Alignment: GGGGRTTCCCC--- CKGGDTBDMMCTGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Reverse Complement GGGBVADCCCSCCA GGYGCTGTCCATGGTGCTGAA GGYGCTGTCCATGGTGSKGAADCCCSCCA Direction: Forward Position #: 16 Overlap #: 6 Alignment: ---------------GGGBVADCCCSCCA GGYGCTGTCCATGGTGCTGAA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Pax5 Reverse Complement Reverse Complement TGGSGGGDTTCRSCACCATGGACAGCKCC MSGKKRCGCWDCABTGBBCD MBGGBRSGCTTCAVYRCCMDGGACAGCKCC Direction: Forward Position #: 2 Overlap #: 19 Alignment: -TGGSGGGDTTCRSCACCATGGACAGCKCC MSGKKRCGCWDCABTGBBCD---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Reverse Complement MBGGBRSGCTTCAVYRCCMDGGACAGCKCC BGRRRGRGGRTGRTTYGGGG BGRRVGGGGRTGVTTYGGGRCCMDGGACAGCKCC Direction: Forward Position #: 5 Overlap #: 16 Alignment: ----MBGGBRSGCTTCAVYRCCMDGGACAGCKCC BGRRRGRGGRTGRTTYGGGG-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Original Motif Original Motif BGRRVGGGGRTGVTTYGGGRCCMDGGACAGCKCC DGGGYGKGGC DGGGHGGGGVTGVTTYGGGRCCMDGGACAGCKCC Direction: Forward Position #: 1 Overlap #: 10 Alignment: BGRRVGGGGRTGVTTYGGGRCCMDGGACAGCKCC DGGGYGKGGC------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Original Motif Original Motif DGGGHGGGGVTGVTTYGGGRCCMDGGACAGCKCC GGGGCCCAAGGGGG GDGGSCVDRGGGGGTTYGGGRCCMDGGACAGCKCC Direction: Forward Position #: 2 Overlap #: 13 Alignment: -DGGGHGGGGVTGVTTYGGGRCCMDGGACAGCKCC GGGGCCCAAGGGGG--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Original Motif Reverse Complement GDGGSCVDRGGGGGTTYGGGRCCMDGGACAGCKCC GGGGGYGGGG GGGGGYGGGGGGGGTTYGGGRCCMDGGACAGCKCC Direction: Forward Position #: 1 Overlap #: 10 Alignment: GDGGSCVDRGGGGGTTYGGGRCCMDGGACAGCKCC GGGGGYGGGG------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 7 Original Motif Reverse Complement GGGGGYGGGGGGGGTTYGGGRCCMDGGACAGCKCC GGGGMGGG GGGGVGGGGGGGGGTTYGGGRCCMDGGACAGCKCC Direction: Forward Position #: 1 Overlap #: 8 Alignment: GGGGGYGGGGGGGGTTYGGGRCCMDGGACAGCKCC GGGGMGGG--------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Reverse Complement Reverse Complement GGYGCTGTCCDYGGMCCCKAACCCCCCCCCVCCCC GYRYCCMTKGGYRSC GGYGCWBYCCWBGGYVSCKAACCCCCCCCCVCCCC Direction: Forward Position #: 4 Overlap #: 15 Alignment: GGYGCTGTCCDYGGMCCCKAACCCCCCCCCVCCCC ---GYRYCCMTKGGYRSC----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_5-13 Combined Motif Reverse Complement Original Motif GGGGVGGGGGGGGGTTYGSVKCCVWGGKBWGCKCC BKAGGGGDAD GGGGVGGGGRGGGGDDHGSVKCCVWGGKBWGCKCC Direction: Forward Position #: 8 Overlap #: 10 Alignment: GGGGVGGGGGGGGGTTYGSVKCCVWGGKBWGCKCC -------BKAGGGGDAD------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 43 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA REST Reverse Complement Reverse Complement GTTGACCTTTGACCTTT GGYGCTGTCCATGGTGCTGAA GGYGYTGWCCTTKGWSCTKWA Direction: Forward Position #: 4 Overlap #: 17 Alignment: ---GTTGACCTTTGACCTTT- GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Reverse Complement GGYGYTGWCCTTKGWSCTKWA TGRCCTKTGHCCKAB TGRSCKYTGHCCTWBGWSCTKWA Direction: Forward Position #: 3 Overlap #: 13 Alignment: --GGYGYTGWCCTTKGWSCTKWA TGRCCTKTGHCCKAB-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Original Motif Reverse Complement TGRSCKYTGHCCTWBGWSCTKWA TGAACKCBWTGACCC TGWRCBCBHTGACCHWBGWSCTKWA Direction: Forward Position #: 3 Overlap #: 13 Alignment: --TGRSCKYTGHCCTWBGWSCTKWA TGAACKCBWTGACCC---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif TWYAGSWCBWDGGTCAHBGBGKWCA VDBHMAGGTCACCCTGACCY TWYAGVDCBHDGGTCAHBVTGDHCH Direction: Forward Position #: 6 Overlap #: 20 Alignment: TWYAGSWCBWDGGTCAHBGBGKWCA -----VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Reverse Complement Original Motif HGDDCAVBDTGACCDHBGDVCTKWA TKKTTTGTTTTTTT HGDDCAVBDTGACCDHBGDVCTKDWTTGTTTTTTT Direction: Forward Position #: 22 Overlap #: 4 Alignment: HGDDCAVBDTGACCDHBGDVCTKWA---------- ---------------------TKKTTTGTTTTTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif EWSR1-FLI1 Reverse Complement Original Motif AAAAAAACAAWDYAGVDCBHDGGTCAHBVTGDHCH GGAAGGAAGGAAGGAAGG GGAARRAARSAAGGAAGGDCBHDGGTCAHBVTGDHCH Direction: Forward Position #: 3 Overlap #: 16 Alignment: --AAAAAAACAAWDYAGVDCBHDGGTCAHBVTGDHCH GGAAGGAAGGAAGGAAGG------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Ar Reverse Complement Reverse Complement HGDDCAVBDTGACCDHBGDCCTTCCTTSMTTMMTTCC VRVDGGHACAVDDKGTHCTDWH VRHGGGHACDVTGDSYHCKDWHCTTCCTTSMTTMMTTCC Direction: Forward Position #: 3 Overlap #: 20 Alignment: --HGDDCAVBDTGACCDHBGDCCTTCCTTSMTTMMTTCC VRVDGGHACAVDDKGTHCTDWH----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif VRHGGGHACDVTGDSYHCKDWHCTTCCTTSMTTMMTTCC VHRGGTCABDBTGMCCTB VDVGGKCACDVTGHCCTBKDWHCTTCCTTSMTTMMTTCC Direction: Forward Position #: 1 Overlap #: 18 Alignment: VRHGGGHACDVTGDSYHCKDWHCTTCCTTSMTTMMTTCC VHRGGTCABDBTGMCCTB--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Original Motif Original Motif VDVGGKCACDVTGHCCTBKDWHCTTCCTTSMTTMMTTCC BAACGTCCGC BAASGTCMGBVTGHCCTBKDWHCTTCCTTSMTTMMTTCC Direction: Forward Position #: 1 Overlap #: 10 Alignment: VDVGGKCACDVTGHCCTBKDWHCTTCCTTSMTTMMTTCC BAACGTCCGC----------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 9 Reverse Complement Original Motif GGAARRAARSAAGGAAGDWHRBAGGHCAVBCRGACSTTB CACACAVRCACACA ACMMACVVRMMCWYGGAARRAARSAAGGAAGDWHRBAGGH Direction: Backward Position #: 2 Overlap #: 13 Alignment: GGAARRAARSAAGGAAGDWHRBAGGHCAVBCRGACSTTB- --------------------------CACACAVRCACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 44 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR4A2 NR1H2RXRA Original Motif Original Motif AAGGTCAC AAAGGTCAAAGGTCAAC AAAGGTCAMAGGTCAAC Direction: Forward Position #: 2 Overlap #: 8 Alignment: -AAGGTCAC-------- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Original Motif GTTGACCTYTGACCTTT VDBHMAGGTCACCCTGACCY VDBHMAGGTCACSYTGACCTYTGACCTTT Direction: Forward Position #: 13 Overlap #: 8 Alignment: ------------GTTGACCTYTGACCTTT VDBHMAGGTCACCCTGACCY--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Original Motif Original Motif VDBHMAGGTCACSYTGACCTYTGACCTTT VHRGGTCABDBTGMCCTB VHRGGBCAVGGTSACCTTGACCTYTGACCTTT Direction: Forward Position #: 4 Overlap #: 15 Alignment: ---VDBHMAGGTCACSYTGACCTYTGACCTTT VHRGGTCABDBTGMCCTB-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif AAAGGTCAMAGGTCAAGGTSACCBTGVCCKHV HWDAGHACRHHVTGTHCCHVMV AAAGGTCAAAGRWCAHBGTGWHCBHGMCCKHV Direction: Forward Position #: 7 Overlap #: 22 Alignment: AAAGGTCAMAGGTCAAGGTSACCBTGVCCKHV ------HWDAGHACRHHVTGTHCCHVMV---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif VHRGGYCHBGDWCACBHTGWMCTTTGACCTTT BTRGGDCARAGGKCA VHRGGBHVGGDHMAMGBTSAMCTTTGACCTTT Direction: Forward Position #: 6 Overlap #: 15 Alignment: VHRGGYCHBGDWCACBHTGWMCTTTGACCTTT -----BTRGGDCARAGGKCA------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Original Motif Reverse Complement VHRGGBHVGGDHMAMGBTSAMCTTTGACCTTT AKGYYCAAAGRTCA VDGBBCAARGRTCAMGBTSAMCTTTGACCTTT Direction: Forward Position #: 1 Overlap #: 14 Alignment: VHRGGBHVGGDHMAMGBTSAMCTTTGACCTTT AKGYYCAAAGRTCA------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif AAAGGTCAAAGRTSABCYTGAMCKTTGBBCDB TTCAGCACCATGGACAGCKCC TWMAGSWCMAHGGWCAGCBBVAMCKTTGBBCDB Direction: Forward Position #: 2 Overlap #: 20 Alignment: -AAAGGTCAAAGRTSABCYTGAMCKTTGBBCDB TTCAGCACCATGGACAGCKCC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Reverse Complement VDGBBCAARGRTVVVGCTGWCCHTRGWSCTRWA VAGGCCBBGGCVBB VDGBBCVAGGCYBVGGCBSHCCHTRGWSCTRWA Direction: Forward Position #: 7 Overlap #: 14 Alignment: VDGBBCAARGRTVVVGCTGWCCHTRGWSCTRWA ------VAGGCCBBGGCVBB------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Reverse Complement VDGBBCVAGGCYBVGGCBSHCCHTRGWSCTRWA BGRRRGRGGRTGRTTYGGGG BGRVDGVGSRWGGYYYGGGVBSHCCHTRGWSCTRWA Direction: Forward Position #: 4 Overlap #: 17 Alignment: ---VDGBBCVAGGCYBVGGCBSHCCHTRGWSCTRWA BGRRRGRGGRTGRTTYGGGG---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Reverse Complement Original Motif TWMAGSWCMAHGGHSVVCCCMMKCCWMSCVCHBMCB CCAGYYHVADCCRG TWMAGSWCCMAGBHBVVVCCVRKCCWMSCVCHBMCB Direction: Forward Position #: 9 Overlap #: 14 Alignment: TWMAGSWCMAHGGHSVVCCCMMKCCWMSCVCHBMCB --------CCAGYYHVADCCRG-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 45 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 ESR1 Reverse Complement Reverse Complement MSGKKRCGCWDCABTGBBCD MGGTCAGGGTGACCTRDBHV MGGTBAVGCTKVMCTGBBMD Direction: Backward Position #: 1 Overlap #: 20 Alignment: MSGKKRCGCWDCABTGBBCD MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement MGGTBAVGCTKVMCTGBBMD VRVDGGHACAVDDKGTHCTDWH MGGTBRVDSKDACVBDBKGTHCTDWH Direction: Forward Position #: 5 Overlap #: 16 Alignment: MGGTBAVGCTKVMCTGBBMD------ ----VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Reverse Complement MGGTBRVDSKDACVBDBKGTHCTDWH BAGGYCABHBTGACCKHV VVGKBMMBBBTRMCCKDBGTHCTDWH Direction: Forward Position #: 1 Overlap #: 18 Alignment: MGGTBRVDSKDACVBDBKGTHCTDWH BAGGYCABHBTGACCKHV-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif HWDAGHACBDYGGYMABBBYRVYCBV TTCAGCACCATGGACAGCKCC HTHAGHACCDYGGHCAGBDBVVYCBV Direction: Forward Position #: 1 Overlap #: 21 Alignment: HWDAGHACBDYGGYMABBBYRVYCBV TTCAGCACCATGGACAGCKCC----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Reverse Complement Reverse Complement VVGKBVBHBCTGHCCMDGGTDCTDAH TGACCTCKVVBTGAYCK TVASBTVKHVBTGACCDDGGTDCTDAH Direction: Forward Position #: 2 Overlap #: 16 Alignment: -VVGKBVBHBCTGHCCMDGGTDCTDAH TGACCTCKVVBTGAYCK---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement TVASBTVKHVBTGACCDDGGTDCTDAH BGRRRGRGGRTGRTTYGGGG TBRVVDGDVGVTGRYYBGGGKDCTDAH Direction: Forward Position #: 2 Overlap #: 20 Alignment: TVASBTVKHVBTGACCDDGGTDCTDAH -BGRRRGRGGRTGRTTYGGGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Reverse Complement TBRVVDGDVGVTGRYYBGGGKDCTDAH TGRCCTKTGHCCKAB TBRBCTKTGVVYGABYBGGGKDCTDAH Direction: Forward Position #: 1 Overlap #: 15 Alignment: TBRVVDGDVGVTGRYYBGGGKDCTDAH TGRCCTKTGHCCKAB------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Reverse Complement Reverse Complement HTHAGHYCCCVKBTCMVVCAYAGBKBA CCCCCTTGGGCCCC HTHASCCCCYWKGKCCCCCAYAGBKBA Direction: Forward Position #: 5 Overlap #: 14 Alignment: HTHAGHYCCCVKBTCMVVCAYAGBKBA ----CCCCCTTGGGCCCC--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Original Motif TBRBCTKTGGGGGYCYWKGGGGSTDAH TGAMCTTTGMMCYT TGAMCTTTGVVSBYCYWKGGGGSTDAH Direction: Forward Position #: 1 Overlap #: 14 Alignment: TBRBCTKTGGGGGYCYWKGGGGSTDAH TGAMCTTTGMMCYT------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Reverse Complement Reverse Complement HTHASCCCCYWKGMBSBVCAAAGRTCA TGMYCTTTGBCCK HTHABSMCCTTTGVHCBVCAAAGRTCA Direction: Forward Position #: 5 Overlap #: 13 Alignment: HTHASCCCCYWKGMBSBVCAAAGRTCA ----TGMYCTTTGBCCK---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 46 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RORA_1 ESR1 Reverse Complement Reverse Complement TGACCTDVWT MGGTCAGGGTGACCTRDBHV VTGACCTDDDHMGGTCAGGG Direction: Backward Position #: 2 Overlap #: 10 Alignment: ---------TGACCTDVWT- MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Combined Motif Original Motif Reverse Complement VTGACCTDDDHMGGTCAGGG TGAACKCBWTGACCC VTGAMCKVDHTVRSYCAGGG Direction: Forward Position #: 2 Overlap #: 15 Alignment: VTGACCTDDDHMGGTCAGGG -TGAACKCBWTGACCC---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA Combined Motif Reverse Complement Reverse Complement CCCTGKSKVAHHVRGYTCAV GTTGACCTTTGACCTTT CCCTGKSKVAHHVRGTTSACCTTTGACCTTT Direction: Forward Position #: 15 Overlap #: 6 Alignment: CCCTGKSKVAHHVRGYTCAV----------- --------------GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Reverse Complement CCCTGKSKVAHHVRGTTSACCTTTGACCTTT TGACCTCKVVBTGAYCK CCCTGKGDCMTVDVGBTGACCTTTGACCTTT Direction: Forward Position #: 6 Overlap #: 17 Alignment: CCCTGKSKVAHHVRGTTSACCTTTGACCTTT -----TGACCTCKVVBTGAYCK--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Reverse Complement Original Motif AAAGGTCAAAGGTCAVCBHVARGDCRCAGGG TGAMCTTTGMMCYT AAAGGTSAAMKKTSAMCHBVARGDCRCAGGG Direction: Forward Position #: 6 Overlap #: 14 Alignment: AAAGGTCAAAGGTCAVCBHVARGDCRCAGGG -----TGAMCTTTGMMCYT------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Reverse Complement AAAGGTSAAMKKTSAMCHBVARGDCRCAGGG TGRCCTKTGHCCKAB AAAGGTSAMCKKTGVMCBHVARGDCRCAGGG Direction: Forward Position #: 6 Overlap #: 15 Alignment: AAAGGTSAAMKKTSAMCHBVARGDCRCAGGG -----TGRCCTKTGHCCKAB----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Original Motif Reverse Complement AAAGGTSAMCKKTGVMCBHVARGDCRCAGGG GGYGCTGTCCATGGTGCTGAA AAAGGTSAMCKKTGVMCBHVARGDCRCWGKCCATGGTGCTGAA Direction: Forward Position #: 23 Overlap #: 9 Alignment: AAAGGTSAMCKKTGVMCBHVARGDCRCAGGG------------ ----------------------GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Reverse Complement AAAGGTSAMCKKTGVMCBHVARGDCRCWGKCCATGGTGCTGAA TGMYCTTTGBCCK TGAHMKKTGVMCKKTGVMCBHVARGDCRCWGKCCATGGTGCTGAA Direction: Forward Position #: 3 Overlap #: 11 Alignment: --AAAGGTSAMCKKTGVMCBHVARGDCRCWGKCCATGGTGCTGAA TGMYCTTTGBCCK-------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif TTCAGCACCATGGRCWGMGHCMTVHVGRBCARRGRBCAYYRHTCA HWDAGHACRHHVTGTHCCHVMV TTCAGCACCAHGVASWRCRHCVTGTHSVHVAVRGRBCAYYRHTCA Direction: Forward Position #: 11 Overlap #: 22 Alignment: TTCAGCACCATGGRCWGMGHCMTVHVGRBCARRGRBCAYYRHTCA ----------HWDAGHACRHHVTGTHCCHVMV------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Reverse Complement Reverse Complement TGAHMKKTGVMCKBTVHVSHACAVGDMGKWSTVCHTGGTGCTGAA BGRRRGRGGRTGRTTYGGGG BGRVVGGKGRTSKTTBGGGDACAVGDMGKWSTVCHTGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 20 Alignment: TGAHMKKTGVMCKBTVHVSHACAVGDMGKWSTVCHTGGTGCTGAA BGRRRGRGGRTGRTTYGGGG------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 47 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 ESR1 Original Motif Reverse Complement RGKTCABVVRGAGGTCA MGGTCAGGGTGACCTRDBHV DSRKSRTGRMCDGGBCAMGG Direction: Backward Position #: 1 Overlap #: 17 Alignment: ---RGKTCABVVRGAGGTCA MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Original Motif Original Motif DSRKSRTGRMCDGGBCAMGG VHRGGTCABDBTGMCCTB VHRGGTCABGDHSHSBTBAMGG Direction: Forward Position #: 3 Overlap #: 16 Alignment: --DSRKSRTGRMCDGGBCAMGG VHRGGTCABDBTGMCCTB---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement CCYTBABSHSHHCVTGACCKHV MSGKKRCGCWDCABTGBBCD CCBKBACGCHDCVVTGHHCDHV Direction: Forward Position #: 1 Overlap #: 20 Alignment: CCYTBABSHSHHCVTGACCKHV MSGKKRCGCWDCABTGBBCD-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement CCBKBACGCHDCVVTGHHCDHV VRVDGGHACAVDDKGTHCTDWH CCBKBRVVBGHMCVBGDBSTHCTDWH Direction: Forward Position #: 5 Overlap #: 18 Alignment: CCBKBACGCHDCVVTGHHCDHV---- ----VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Original Motif CCBKBRVVBGHMCVBGDBSTHCTDWH BTRGGDCARAGGKCA CCBTDRVDSRDASDBBABSTHCTDWH Direction: Forward Position #: 3 Overlap #: 15 Alignment: CCBKBRVVBGHMCVBGDBSTHCTDWH --BTRGGDCARAGGKCA--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Combined Motif Reverse Complement Original Motif HWDAGHASVTBVHSTDKSHVMHABGG GGGTCAWBGRGTTCA HWDAGHASVTBVHSTDKGGTCAHBGRGTTCA Direction: Forward Position #: 17 Overlap #: 10 Alignment: HWDAGHASVTBVHSTDKSHVMHABGG----- ----------------GGGTCAWBGRGTTCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Reverse Complement Original Motif TGAACMCBHTGACCYDASDBBABSTHCTDWH TGAMCTTTGMMCYT TGWRMMCBTTGMVCYDASDBBABSTHCTDWH Direction: Forward Position #: 3 Overlap #: 14 Alignment: TGAACMCBHTGACCYDASDBBABSTHCTDWH --TGAMCTTTGMMCYT--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Reverse Complement TGWRMMCBTTGMVCYDASDBBABSTHCTDWH CCCCCTTGGGCCCC TGHVCCCTTKGVCCCCASDBBABSTHCTDWH Direction: Forward Position #: 3 Overlap #: 14 Alignment: TGWRMMCBTTGMVCYDASDBBABSTHCTDWH --CCCCCTTGGGCCCC--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Reverse Complement Original Motif HWDAGHASVTBVHSTGGGGVCRAAGGGVDCA RGGBCAAAGKYCA VDDVSAAMGKBVVSTGGGGVCRAAGGGVDCA Direction: Forward Position #: 1 Overlap #: 13 Alignment: HWDAGHASVTBVHSTGGGGVCRAAGGGVDCA RGGBCAAAGKYCA------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement VDDVSAAMGKBVVSTGGGGVCRAAGGGVDCA BGRRRGRGGRTGRTTYGGGG VDDVSAHVRDDVVGKGKGGBYHRRGGGVDCA Direction: Forward Position #: 7 Overlap #: 20 Alignment: VDDVSAAMGKBVVSTGGGGVCRAAGGGVDCA ------BGRRRGRGGRTGRTTYGGGG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 48 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Ar Original Motif Original Motif CCAGYYHVADCCRG HWDAGHACRHHVTGTHCCHVMV MVMCAGYBYGWDCCDGHWDAGH Direction: Backward Position #: 3 Overlap #: 14 Alignment: ------CCAGYYHVADCCRG-- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Reverse Complement MVMCAGYBYGWDCCDGHWDAGH MGGTCAGGGTGACCTRDBHV MVVYMRBBBKDACCDGDDHVGH Direction: Forward Position #: 1 Overlap #: 20 Alignment: MVMCAGYBYGWDCCDGHWDAGH MGGTCAGGGTGACCTRDBHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Original Motif Reverse Complement MVVYMRBBBKDACCDGDDHVGH VAGGCCBBGGCVBB VAGGCCDBGBBVVCCDGDDHVGH Direction: Forward Position #: 2 Overlap #: 13 Alignment: -MVVYMRBBBKDACCDGDDHVGH VAGGCCBBGGCVBB--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement HCBHDHCDGGBVBBCBDGGCCTV BGRRRGRGGRTGRTTYGGGG HSDDDGVRGGTGDYYYGGGSCTV Direction: Forward Position #: 1 Overlap #: 20 Alignment: HCBHDHCDGGBVBBCBDGGCCTV BGRRRGRGGRTGRTTYGGGG--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Reverse Complement Reverse Complement VAGSCCCMMMHCACCMVCHDHSH CCCCCTTGGGCCCC VASCCCCHWVBSMCCCVCHDHSH Direction: Forward Position #: 3 Overlap #: 14 Alignment: VAGSCCCMMMHCACCMVCHDHSH --CCCCCTTGGGCCCC------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Original Motif Reverse Complement VASCCCCHWVBSMCCCVCHDHSH BAGGYCABHBTGACCKHV VAGSCCMHHVTGMCCBHVHDHSH Direction: Forward Position #: 1 Overlap #: 18 Alignment: VASCCCCHWVBSMCCCVCHDHSH BAGGYCABHBTGACCKHV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Reverse Complement HSDDDVHBGGYCAVHDYGGSCTV TGRCCTKTGHCCKAB HBGVVCTKKGYCMBHBYGGSCTV Direction: Forward Position #: 2 Overlap #: 15 Alignment: HSDDDVHBGGYCAVHDYGGSCTV -TGRCCTKTGHCCKAB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif VAGSCCMBHBRGMCRRAGVBCVH DGVBCABTGDWGCGKRRCSR VRVBCMVBBDDGMSDRRSVDCVH Direction: Forward Position #: 1 Overlap #: 20 Alignment: VAGSCCMBHBRGMCRRAGVBCVH DGVBCABTGDWGCGKRRCSR--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Reverse Complement Reverse Complement HBGHVSKKHSRCDDBVVRGBVKV TGACCTCKVVBTGAYCK TBRCCBBKHSDYGAYCKRGBVKV Direction: Forward Position #: 1 Overlap #: 17 Alignment: HBGHVSKKHSRCDDBVVRGBVKV TGACCTCKVVBTGAYCK------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif VRVBCMYGKTCMHSDRBVGGKBA TTCAGCACCATGGACAGCKCC TTCAGVACCMYGGWCAGSDVBVGGKBA Direction: Forward Position #: 5 Overlap #: 17 Alignment: ----VRVBCMYGKTCMHSDRBVGGKBA TTCAGCACCATGGACAGCKCC------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Results created by MOTIFSIM on 11-20-2016 13:44:02 Runtime: 673.485 seconds MOTIFSIM is written by Ngoc Tam L. 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