**************************************************************************************************************************************************************************************************** MOTIFSIM - Motif Similarity Detection Tool Version 2.1 **************************************************************************************************************************************************************************************************** INPUT **************************************************************************************************************************************************************************************************** Input Parameters Number of files: 2 Number of top significant motifs: 10 Number of best matches: 10 Similarity cutoff: >= 0.75 Matching motif database: UniProbe Mus Musculus Phylogenetic tree: Yes Combined similar motifs: Yes Output file type: All Output file format: All Input files and motif counts File name Count of motifs Dataset # MEME-ChIP_DM721.txt 11 1 PScanChIP_DM721.txt 37 2 **************************************************************************************************************************************************************************************************** RESULTS **************************************************************************************************************************************************************************************************** *************************************************************** Combined Motifs for Top Best Match Motif ID 1 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 1 EWSR1-FLI1 Reverse Complement Reverse Complement MTTCCK CCTTCCTTCCTTCCTTCC CCTTCCTTCCTTCCTTCC Direction: Backward Position #: 12 Overlap #: 6 Alignment: -MTTCCK----------- CCTTCCTTCCTTCCTTCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Reverse Complement GGAAGGAAGGAAGGAAGG GCGGACGTTV GCGGAMGKWAGGAAGGAAGG Direction: Forward Position #: 3 Overlap #: 8 Alignment: --GGAAGGAAGGAAGGAAGG GCGGACGTTV---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MZF1_5-13 Original Motif Original Motif GCGGAMGKWAGGAAGGAAGG BKAGGGGDAD BKAGSGGAAGKWAGGAAGGAAGG Direction: Forward Position #: 4 Overlap #: 7 Alignment: ---GCGGAMGKWAGGAAGGAAGG BKAGGGGDAD------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NFKB1 Combined Motif Reverse Complement Reverse Complement CCTTCCTTCCTWRCTTCCSCTYB GGGGAAKCCCC CCTTCCTTCSKKGMWTCCCCTYB Direction: Forward Position #: 10 Overlap #: 11 Alignment: CCTTCCTTCCTWRCTTCCSCTYB ---------GGGGAAKCCCC--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Original Motif BKAGGGGAWYCYYSGAAGGAAGG BTRGGDCARAGGKCA BKAGGGSAAHVBYSRAAGGAAGG Direction: Forward Position #: 1 Overlap #: 15 Alignment: BKAGGGGAWYCYYSGAAGGAAGG BTRGGDCARAGGKCA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 7 Reverse Complement Original Motif CCTTCCTTMSMBVHTTSCCCTRB CCCRCCCC CCCKYCCYTMSMBVHTTSCCCTRB Direction: Forward Position #: 2 Overlap #: 7 Alignment: -CCTTCCTTMSMBVHTTSCCCTRB CCCRCCCC---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif BKAGGGSAAHVBYSRAKGGKRGGG TTCAGCACCATGGACAGCKCC TTCAGCACCDDGGRSAGHDBYSRAKGGKRGGG Direction: Forward Position #: 9 Overlap #: 13 Alignment: --------BKAGGGSAAHVBYSRAKGGKRGGG TTCAGCACCATGGACAGCKCC----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Reverse Complement CCCKYCCYTMSKBHDCTSKCCDDGGTGCTGAA MGCCCCCTGMCA MGCCCCCTBCCHTMSKBHDCTSKCCDDGGTGCTGAA Direction: Forward Position #: 5 Overlap #: 8 Alignment: ----CCCKYCCYTMSKBHDCTSKCCDDGGTGCTGAA MGCCCCCTGMCA------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement TTCAGCACCDDGGRSAGHDBYSRAHGGBAGGGGGCR BGRRRGRGGRTGRTTYGGGG TTCAGCACCDDGGRSAGHDBYSRAHGGDRGGGGGVTGRTTYGGGG Direction: Forward Position #: 26 Overlap #: 11 Alignment: TTCAGCACCDDGGRSAGHDBYSRAHGGBAGGGGGCR--------- -------------------------BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif CCCCMAAMCAVCCCCCKHCCHTMSKBHDCTSKCCDDGGTGCTGAA HWDAGHACRHHVTGTHCCHVMV CCCCMAAMCDRSMMCMBHSYGTMCBBVVCTSKCCDDGGTGCTGAA Direction: Forward Position #: 8 Overlap #: 22 Alignment: CCCCMAAMCAVCCCCCKHCCHTMSKBHDCTSKCCDDGGTGCTGAA -------HWDAGHACRHHVTGTHCCHVMV---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif E2F1 Original Motif Reverse Complement CCCCMAAMCDRSMMCMBHSYGTMCBBVVCTSKCCDDGGTGCTGAA GCGCSAAA SCSCMAAACDRSMMCMBHSYGTMCBBVVCTSKCCDDGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 8 Alignment: CCCCMAAMCDRSMMCMBHSYGTMCBBVVCTSKCCDDGGTGCTGAA GCGCSAAA------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 2 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 2 Motif 11 Original Motif Original Motif AMACA CAYACACACACACA CAYACACACACACA Direction: Forward Position #: 6 Overlap #: 5 Alignment: -----AMACA---- CAYACACACACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 9 Original Motif Original Motif CAYACACACACACA CACACAVRCACACA CACACACACACACA Direction: Forward Position #: 1 Overlap #: 14 Alignment: CAYACACACACACA CACACAVRCACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Original Motif CACACACACACACA CCCCMAAMCAMCCMCMMMCV CCCCMAAMCAMCCMCACACACACACACA Direction: Forward Position #: 15 Overlap #: 6 Alignment: --------------CACACACACACACA CCCCMAAMCAMCCMCMMMCV-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 10 Reverse Complement Original Motif TGTGTGTGTGTGTGRGGRTGRTTYGGGG TKKTTTGTTTTTTT TTGTKTGTBTKTKTGRGGRTGRTTYGGGG Direction: Forward Position #: 2 Overlap #: 13 Alignment: -TGTGTGTGTGTGTGRGGRTGRTTYGGGG TKKTTTGTTTTTTT--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Ar Original Motif Reverse Complement TTGTKTGTBTKTKTGRGGRTGRTTYGGGG VRVDGGHACAVDDKGTHCTDWH VRVDGGHACAVDDKGTHCTTDTKTGTBTKTKTGRGGRTGRTTYGGGG Direction: Forward Position #: 19 Overlap #: 4 Alignment: ------------------TTGTKTGTBTKTKTGRGGRTGRTTYGGGG VRVDGGHACAVDDKGTHCTDWH------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Reverse Complement VRVDGGHACAVDDKGTHCTTDTKTGTBTKTKTGRGGRTGRTTYGGGG TGRCCTKTGHCCKAB VRVDGGHACAVDDTGDYCTTTBBYSTDBKTKTGRGGRTGRTTYGGGG Direction: Forward Position #: 14 Overlap #: 15 Alignment: VRVDGGHACAVDDKGTHCTTDTKTGTBTKTKTGRGGRTGRTTYGGGG -------------TGRCCTKTGHCCKAB------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ArntAhr Reverse Complement Reverse Complement CCCCMAAMCAMCCMCARAYVDASMVVAAAGKDCAHHVTGTHCCHVMV CACGCM CMCSCMAAMCAMCCMCARAYVDASMVVAAAGKDCAHHVTGTHCCHVMV Direction: Forward Position #: 2 Overlap #: 5 Alignment: -CCCCMAAMCAMCCMCARAYVDASMVVAAAGKDCAHHVTGTHCCHVMV CACGCM------------------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif CMCSCMAAMCAMCCMCARAYVDASMVVAAAGKDCAHHVTGTHCCHVMV DGVBCABTGDWGCGKRRCSR CMCSCMAAMCAMCCMCARAYVDASMVVAAAGDRCDHHVTGWWSCVDVVCSR Direction: Forward Position #: 32 Overlap #: 17 Alignment: CMCSCMAAMCAMCCMCARAYVDASMVVAAAGKDCAHHVTGTHCCHVMV--- -------------------------------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Original Motif MSGVBDVGSWWCAVHDDGMHCTTTBBYSTDBKTKTGRGGRTGRTTYGSGYG TGAMCTTTGMMCYT TGAMCTYBGVHVHKSWWCAVHDDGMHCTTTBBYSTDBKTKTGRGGRTGRTTYGSGYG Direction: Forward Position #: 7 Overlap #: 8 Alignment: ------MSGVBDVGSWWCAVHDDGMHCTTTBBYSTDBKTKTGRGGRTGRTTYGSGYG TGAMCTTTGMMCYT------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Reverse Complement Reverse Complement CMCSCMAAMCAMCCMCARAYVDASMVVAAAGDRCDHHVTGWWSYDVDBCVMAGRTCA MGCCCCCTGMCA CMCSCMAAMCRCCCCCWRACADASMVVAAAGDRCDHHVTGWWSYDVDBCVMAGRTCA Direction: Forward Position #: 10 Overlap #: 12 Alignment: CMCSCMAAMCAMCCMCARAYVDASMVVAAAGDRCDHHVTGWWSYDVDBCVMAGRTCA ---------MGCCCCCTGMCA------------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 3 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 3 EWSR1-FLI1 Original Motif Original Motif AGSCWGG GGAAGGAAGGAAGGAAGG GGAAGGAAGGMAGGAAGG Direction: Forward Position #: 8 Overlap #: 7 Alignment: -------AGSCWGG---- GGAAGGAAGGAAGGAAGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Reverse Complement CCTTCCTRCCTTCCTTCC MGCCCCCTGMCA MSCYYCCTRCCWTCCTTCC Direction: Forward Position #: 2 Overlap #: 11 Alignment: -CCTTCCTRCCTTCCTTCC MGCCCCCTGMCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Tcfcp2l1 Original Motif Original Motif MSCYYCCTRCCWTCCTTCC CCAGYYHVADCCRG CCVSYYCCWRCCWKCCTTCC Direction: Forward Position #: 2 Overlap #: 13 Alignment: -MSCYYCCTRCCWTCCTTCC CCAGYYHVADCCRG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Reverse Complement CCVSYYCCWRCCWKCCTTCC GGYGCTGTCCATGGTGCTGAA GGYGCTGTCCMDGGTSCTGMMWKCCTTCC Direction: Forward Position #: 10 Overlap #: 12 Alignment: ---------CCVSYYCCWRCCWKCCTTCC GGYGCTGTCCATGGTGCTGAA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif SP1 Reverse Complement Reverse Complement GGAAGGRWRRCAGSACCDRGGACAGCKCC GGGGGYGGGG GGGGRAGGGGRRCAGSACCDRGGACAGCKCC Direction: Forward Position #: 3 Overlap #: 8 Alignment: --GGAAGGRWRRCAGSACCDRGGACAGCKCC GGGGGYGGGG--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Reverse Complement GGYGCTGTCCMDGGTSCTGMMCCCCTKCCCC VAGGCCBBGGCVBB GGYGCTGTCCVAGGYCCBGVCHCCCTKCCCC Direction: Forward Position #: 11 Overlap #: 14 Alignment: GGYGCTGTCCMDGGTSCTGMMCCCCTKCCCC ----------VAGGCCBBGGCVBB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 7 Combined Motif Original Motif Original Motif GGYGCTGTCCVAGGYCCBGVCHCCCTKCCCC CCCRCCCC GGYGCTGTCCCRSSCCCBGVCHCCCTKCCCC Direction: Forward Position #: 9 Overlap #: 8 Alignment: GGYGCTGTCCVAGGYCCBGVCHCCCTKCCCC --------CCCRCCCC--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif GGYGCTGTCCCRSSCCCBGVCHCCCTKCCCC VDBHMAGGTCACCCTGACCY GGYGCTGTCCCRSSCCBDGVCVSSYYDCCCYGACCY Direction: Forward Position #: 17 Overlap #: 15 Alignment: GGYGCTGTCCCRSSCCCBGVCHCCCTKCCCC----- ----------------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RORA_1 Reverse Complement Original Motif MGGTCMGGGDKKSSBGVCDBGGSSKGGGACAGCKCC AWVDAGGTCA AWVDAGGTCAGGGDKKSSBGVCDBGGSSKGGGACAGCKCC Direction: Forward Position #: 5 Overlap #: 6 Alignment: ----MGGTCMGGGDKKSSBGVCDBGGSSKGGGACAGCKCC AWVDAGGTCA------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 Combined Motif Original Motif Original Motif AWVDAGGTCAGGGDKKSSBGVCDBGGSSKGGGACAGCKCC DGGGYGKGGC AWVDAGGTCAGGGDKKSBGGGYGKGGSSKGGGACAGCKCC Direction: Forward Position #: 18 Overlap #: 10 Alignment: AWVDAGGTCAGGGDKKSSBGVCDBGGSSKGGGACAGCKCC -----------------DGGGYGKGGC------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 4 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 4 NR1H2RXRA Reverse Complement Original Motif KCAGAG AAAGGTCAAAGGTCAAC AAAGGTCARAGGTCAAC Direction: Forward Position #: 6 Overlap #: 6 Alignment: -----KCAGAG------ AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Original Motif AAAGGTCARAGGTCAAC BTRGGDCARAGGKCA VDRGGKCARAGGTCAAC Direction: Forward Position #: 1 Overlap #: 15 Alignment: AAAGGTCARAGGTCAAC BTRGGDCARAGGKCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Original Motif GTTGACCTKTGRCCKDB TGAMCTTTGMMCYT TGAMCKTTGACCTKTGRCCKDB Direction: Forward Position #: 6 Overlap #: 9 Alignment: -----GTTGACCTKTGRCCKDB TGAMCTTTGMMCYT-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Reverse Complement TGAMCKTTGACCTKTGRCCKDB TGMYCTTTGBCCK TGAMCTTTGVCCTKTGRCCKDB Direction: Forward Position #: 1 Overlap #: 13 Alignment: TGAMCKTTGACCTKTGRCCKDB TGMYCTTTGBCCK--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Original Motif VDRGGKCARAGGBCAAAGRTCA BAACGTCCGC HWASGTCMGHGGBCAAAGRTCA Direction: Forward Position #: 1 Overlap #: 10 Alignment: VDRGGKCARAGGBCAAAGRTCA BAACGTCCGC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Reverse Complement TGAMCTTTGVCCDCRGACSTWD MGCCCCCTGMCA HGMCCYYTGVCMDCRGACSTWD Direction: Forward Position #: 1 Overlap #: 12 Alignment: TGAMCTTTGVCCDCRGACSTWD MGCCCCCTGMCA---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Reverse Complement Reverse Complement HWASGTCMGHRGBCAKKGGRCH GGGGGYGGGG HWASGTCVGBGGYSRGGGGRCH Direction: Forward Position #: 8 Overlap #: 10 Alignment: HWASGTCMGHRGBCAKKGGRCH -------GGGGGYGGGG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Reverse Complement HWASGTCVGBGGYSRGGGGRCH GGYGCTGTCCATGGTGCTGAA GGHDMTGTCCRBGGTSVKGRRRCH Direction: Forward Position #: 3 Overlap #: 19 Alignment: --HWASGTCVGBGGYSRGGGGRCH GGYGCTGTCCATGGTGCTGAA--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 8 Combined Motif Reverse Complement Reverse Complement HGMMMCRVSACCVKGGACARHDCC TCCCAG HGTCCCAGSACCVKGGACARHDCC Direction: Forward Position #: 3 Overlap #: 6 Alignment: HGMMMCRVSACCVKGGACARHDCC --TCCCAG---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Reverse Complement HGTCCCAGSACCVKGGACARHDCC VAGGCCBBGGCVBB HGTCCCAGGMCCBKGSVCVRHDCC Direction: Forward Position #: 6 Overlap #: 14 Alignment: HGTCCCAGSACCVKGGACARHDCC -----VAGGCCBBGGCVBB----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 5 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 5 RREB1 Reverse Complement Reverse Complement RARAT BGRRRGRGGRTGRTTYGGGG BGRRRGRRGATGRTTYGGGG Direction: Backward Position #: 10 Overlap #: 5 Alignment: ------RARAT--------- BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 10 Reverse Complement Reverse Complement CCCCMAAMCATCKMCMMMCB AAAAAAACAAARRA AAAAMMMCAAAVCATCKMCMMMCB Direction: Forward Position #: 5 Overlap #: 10 Alignment: ----CCCCMAAMCATCKMCMMMCB AAAAAAACAAARRA---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR4A2 Combined Motif Original Motif Original Motif AAAAMMMCAAAVCATCKMCMMMCB AAGGTCAC AAAARVHCAMAVCATCKMCMMMCB Direction: Forward Position #: 3 Overlap #: 8 Alignment: AAAAMMMCAAAVCATCKMCMMMCB --AAGGTCAC-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Reverse Complement BGRRRGRRGATGBTYTGHVMTTTT AKGYYCAAAGRTCA AKGYBSAAAGRWSATGBTYTGHVMTTTT Direction: Forward Position #: 5 Overlap #: 10 Alignment: ----BGRRRGRRGATGBTYTGHVMTTTT AKGYYCAAAGRTCA-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Original Motif Reverse Complement AKGYBSAAAGRWSATGBTYTGHVMTTTT GCGGACGTTV GCGGABGTTVAAAGRWSATGBTYTGHVMTTTT Direction: Forward Position #: 5 Overlap #: 6 Alignment: ----AKGYBSAAAGRWSATGBTYTGHVMTTTT GCGGACGTTV---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Original Motif AAAARVHCAMAVCATSWMCTTTVAACBTCCGC AAAGGTCAAAGGTCAAC AAAGGTMAAAGGTCAAHVCATSWMCTTTVAACBTCCGC Direction: Forward Position #: 7 Overlap #: 11 Alignment: ------AAAARVHCAMAVCATSWMCTTTVAACBTCCGC AAAGGTCAAAGGTCAAC--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif GCGGABGTTVAAAGRWSATGBHTTGACCTTTRACCTTT BTRGGDCARAGGKCA GCGGABGTTVVDRGGDCAWRGBTYRACCTTTRACCTTT Direction: Forward Position #: 11 Overlap #: 15 Alignment: GCGGABGTTVAAAGRWSATGBHTTGACCTTTRACCTTT ----------BTRGGDCARAGGKCA------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif GCGGABGTTVVDRGGDCAWRGBTYRACCTTTRACCTTT TTCAGCACCATGGACAGCKCC TTCAGCACCDYGGACRKHVVHRGGDCAWRGBTYRACCTTTRACCTTT Direction: Forward Position #: 10 Overlap #: 12 Alignment: ---------GCGGABGTTVVDRGGDCAWRGBTYRACCTTTRACCTTT TTCAGCACCATGGACAGCKCC-------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Original Motif TTCAGCACCDYGGACRKHVVHRGGDCAWRGBTYRACCTTTRACCTTT RGKTCABVVRGAGGTCA TTCAGCACCDYGGACRGBTCADGGDSAKRKSWYRACCTTTRACCTTT Direction: Forward Position #: 16 Overlap #: 17 Alignment: TTCAGCACCDYGGACRKHVVHRGGDCAWRGBTYRACCTTTRACCTTT ---------------RGKTCABVVRGAGGTCA--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RORA_1 Reverse Complement Original Motif AAAGGTMAAAGGTMMWSRMYTSDCCDTGAVCKGTCCKHGGTGCTGAA AWVDAGGTCA AWMAAGGTCAAAGGTMMWSRMYTSDCCDTGAVCKGTCCKHGGTGCTGAA Direction: Forward Position #: 3 Overlap #: 8 Alignment: --AAAGGTMAAAGGTMMWSRMYTSDCCDTGAVCKGTCCKHGGTGCTGAA AWVDAGGTCA--------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 6 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 6 REST Original Motif Original Motif CMGCRGC TTCAGCACCATGGACAGCKCC TTCAGCASCATGGACAGCKCC Direction: Backward Position #: 13 Overlap #: 7 Alignment: --CMGCRGC------------ TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Original Motif Original Motif TTCAGCASCATGGACAGCKCC BAACGTCCGC BAACGTCMGCASCATGGACAGCKCC Direction: Forward Position #: 5 Overlap #: 6 Alignment: ----TTCAGCASCATGGACAGCKCC BAACGTCCGC--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Reverse Complement Original Motif GGYGCTGTCCATGSTGCRGACGTTV BBVGCCBVGGCCTV BBGGCSCTGKCCTDGSTGCRGACGTTV Direction: Forward Position #: 3 Overlap #: 12 Alignment: --GGYGCTGTCCATGSTGCRGACGTTV BBVGCCBVGGCCTV------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TFAP2A Combined Motif Reverse Complement Original Motif BAACGTCMGCASCDAGGYCAGSGCCBB GCCBBVRGS BAACGTCMGCMSCVDGGYCAGSGCCBB Direction: Forward Position #: 9 Overlap #: 9 Alignment: BAACGTCMGCASCDAGGYCAGSGCCBB --------GCCBBVRGS---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 7 Reverse Complement Reverse Complement BBGGCSCTGKCCDVGSRGCRGACGTTV GGGGMGGG GGGGVGGGCSCTGKCCDVGSRGCRGACGTTV Direction: Forward Position #: 5 Overlap #: 4 Alignment: ----BBGGCSCTGKCCDVGSRGCRGACGTTV GGGGMGGG----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement GGGGVGGGCSCTGKCCDVGSRGCRGACGTTV MSGKKRCGCWDCABTGBBCD GGGGMSGGBVCDSKBCDVBGVGCRGACGTTV Direction: Forward Position #: 5 Overlap #: 20 Alignment: GGGGVGGGCSCTGKCCDVGSRGCRGACGTTV ----MSGKKRCGCWDCABTGBBCD------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Original Motif GGGGMSGGBVCDSKBCDVBGVGCRGACGTTV HGCGTGGGCGK HGCGKGGGSGKBVCDSKBCDVBGVGCRGACGTTV Direction: Forward Position #: 4 Overlap #: 8 Alignment: ---GGGGMSGGBVCDSKBCDVBGVGCRGACGTTV HGCGTGGGCGK----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 Combined Motif Reverse Complement Original Motif BAACGTCMGCVCVVDGBRSHGBVYCSCCCYCGCH DGGGYGKGGC BAACGTCMGCVCDGGGBGGGGBVYCSCCCYCGCH Direction: Forward Position #: 13 Overlap #: 10 Alignment: BAACGTCMGCVCVVDGBRSHGBVYCSCCCYCGCH ------------DGGGYGKGGC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Original Motif Original Motif BAACGTCMGCVCDGGGBGGGGBVYCSCCCYCGCH CCCCKCCCCC BAACGTCMGCVCDGGGBGGGGBCCCCBCCCCSCH Direction: Forward Position #: 23 Overlap #: 10 Alignment: BAACGTCMGCVCDGGGBGGGGBVYCSCCCYCGCH ----------------------CCCCKCCCCC-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Original Motif BAACGTCMGCVCDGGGBGGGGBCCCCBCCCCSCH CCCCMAAMCAMCCMCMMMCV BAACGTCMGCVCDGGGCSVCRMMCCAVCCCCVCMCV Direction: Forward Position #: 17 Overlap #: 18 Alignment: BAACGTCMGCVCDGGGBGGGGBCCCCBCCCCSCH-- ----------------CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 7 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 7 SP1 Original Motif Original Motif CCCRCCCC CCCCKCCCCC CCCCDCCCCC Direction: Backward Position #: 2 Overlap #: 8 Alignment: -CCCRCCCC- CCCCKCCCCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Original Motif Reverse Complement CCCCDCCCCC GCCYCMCCCD SCCCCCCCCH Direction: Forward Position #: 1 Overlap #: 10 Alignment: CCCCDCCCCC GCCYCMCCCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Reverse Complement Original Motif DGGGGGGGGS HGCGTGGGCGK DGSGKGGGSGK Direction: Forward Position #: 1 Overlap #: 10 Alignment: DGGGGGGGGS- HGCGTGGGCGK ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Reverse Complement Original Motif YCSCCCRCSCD CCCCMAAMCAMCCMCMMMCV CCCCMAAMCAMCCCCVCCCVCSCD Direction: Forward Position #: 14 Overlap #: 7 Alignment: -------------YCSCCCRCSCD CCCCMAAMCAMCCMCMMMCV---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NFKB1 Original Motif Original Motif CCCCMAAMCAMCCCCVCCCVCSCD GGGGRTTCCCC GGGGRTYCCCMAAMCAMCCCCVCCCVCSCD Direction: Forward Position #: 7 Overlap #: 5 Alignment: ------CCCCMAAMCAMCCCCVCCCVCSCD GGGGRTTCCCC------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Original Motif Reverse Complement GGGGRTYCCCMAAMCAMCCCCVCCCVCSCD MGCCCCCTGMCA GGGGRTYCCCMAAMSMCCCCHVMCMVCSCD Direction: Forward Position #: 14 Overlap #: 12 Alignment: GGGGRTYCCCMAAMCAMCCCCVCCCVCSCD -------------MGCCCCCTGMCA----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 8 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 8 REST Reverse Complement Reverse Complement TCCCAG GGYGCTGTCCATGGTGCTGAA GGYGCTGTCCCHGGTGCTGAA Direction: Backward Position #: 9 Overlap #: 6 Alignment: -------TCCCAG-------- GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_1-4 Combined Motif Reverse Complement Reverse Complement TTCAGCACCHGGGACAGCKCC TCCCCV TTCAKCMCCHGGGACAGCKCC Direction: Forward Position #: 5 Overlap #: 6 Alignment: TTCAGCACCHGGGACAGCKCC ----TCCCCV----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Original Motif TTCAKCMCCHGGGACAGCKCC CCCCMAAMCAMCCMCMMMCV CCCCMAHYCABCMCCHVSSACAGCKCC Direction: Forward Position #: 7 Overlap #: 14 Alignment: ------TTCAKCMCCHGGGACAGCKCC CCCCMAAMCAMCCMCMMMCV------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Original Motif Reverse Complement CCCCMAHYCABCMCCHVSSACAGCKCC MGCCCCCTGMCA MGCCCCCWDHCABCMCCHVSSACAGCKCC Direction: Forward Position #: 3 Overlap #: 10 Alignment: --CCCCMAHYCABCMCCHVSSACAGCKCC MGCCCCCTGMCA----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Original Motif MGCCCCCWDHCABCMCCHVSSACAGCKCC GSMMCCYARGGKKKC VGMCCCCARGSDBCMCCHVSSACAGCKCC Direction: Forward Position #: 1 Overlap #: 15 Alignment: MGCCCCCWDHCABCMCCHVSSACAGCKCC GSMMCCYARGGKKKC-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Reverse Complement GGYGCTGTSSVHGGRGBDSCMTGGGGRCV GTTGACCTTTGACCTTT GTTGACCTTKGASCTKTSSVHGGRGBDSCMTGGGGRCV Direction: Forward Position #: 10 Overlap #: 8 Alignment: ---------GGYGCTGTSSVHGGRGBDSCMTGGGGRCV GTTGACCTTTGACCTTT--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Reverse Complement Original Motif VGMCCCCARGSDBCMCCHVSSAYAGSTCRAAGGTCAAC CCAGYYHVADCCRG VGMCCCCARGSDBCMCCCRGBHYARVYCRRAGGTCAAC Direction: Forward Position #: 17 Overlap #: 14 Alignment: VGMCCCCARGSDBCMCCHVSSAYAGSTCRAAGGTCAAC ----------------CCAGYYHVADCCRG-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Reverse Complement VGMCCCCARGSDBCMCCCRGBHYARVYCRRAGGTCAAC YCGCCCACGCH YCGCSCMCSCARGSDBCMCCCRGBHYARVYCRRAGGTCAAC Direction: Forward Position #: 4 Overlap #: 8 Alignment: ---VGMCCCCARGSDBCMCCCRGBHYARVYCRRAGGTCAAC YCGCCCACGCH------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Original Motif YCGCSCMCSCARGSDBCMCCCRGBHYARVYCRRAGGTCAAC HWDAGHACRHHVTGTHCCHVMV YCGCSCMCSMWDRGDDCMCCVDGTHCMVVCCRRAGGTCAAC Direction: Forward Position #: 10 Overlap #: 22 Alignment: YCGCSCMCSCARGSDBCMCCCRGBHYARVYCRRAGGTCAAC ---------HWDAGHACRHHVTGTHCCHVMV---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Original Motif GTTGACCTKKGGVVRGHACDVGGYGDDCKDWRSGYGSGCGK BBVGCCBVGGCCTV GTTGACCTKKGGVVRGHACDVGGYGDDSBDDVCGHGGSCKK Direction: Forward Position #: 28 Overlap #: 14 Alignment: GTTGACCTKKGGVVRGHACDVGGYGDDCKDWRSGYGSGCGK ---------------------------BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 9 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 9 Motif 11 Original Motif Original Motif CACACAVRCACACA CAYACACACACACA CACACACACACACA Direction: Forward Position #: 1 Overlap #: 14 Alignment: CACACAVRCACACA CAYACACACACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Original Motif CACACACACACACA CCCCMAAMCAMCCMCMMMCV CCCCMAAMCAMCCMCACACACACACACA Direction: Forward Position #: 15 Overlap #: 6 Alignment: --------------CACACACACACACA CCCCMAAMCAMCCMCMMMCV-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 10 Reverse Complement Original Motif TGTGTGTGTGTGTGRGGRTGRTTYGGGG TKKTTTGTTTTTTT TTGTKTGTKTKTKTGRGGRTGRTTYGGGG Direction: Forward Position #: 2 Overlap #: 13 Alignment: -TGTGTGTGTGTGTGRGGRTGRTTYGGGG TKKTTTGTTTTTTT--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Reverse Complement Reverse Complement CCCCMAAMCAMCCMCARAYARACARACAA TGAACKCBWTGACCC TGAACKCBWTGMCCCMAAMCAMCCMCARAYARACARACAA Direction: Forward Position #: 12 Overlap #: 4 Alignment: -----------CCCCMAAMCAMCCMCARAYARACARACAA TGAACKCBWTGACCC------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Original Motif TGAACKCBWTGMCCCMAAMCAMCCMCARAYARACARACAA HWDAGHACRHHVTGTHCCHVMV TGAACKMDWWGMMCMMMMHSWMCCVCAVAYARACARACAA Direction: Forward Position #: 7 Overlap #: 22 Alignment: TGAACKCBWTGMCCCMAAMCAMCCMCARAYARACARACAA ------HWDAGHACRHHVTGTHCCHVMV------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Reverse Complement TGAACKMDWWGMMCMMMMHSWMCCVCAVAYARACARACAA YCGCCCACGCH YCGYSMACGCHWWGMMCMMMMHSWMCCVCAVAYARACARACAA Direction: Forward Position #: 4 Overlap #: 8 Alignment: ---TGAACKMDWWGMMCMMMMHSWMCCVCAVAYARACARACAA YCGCCCACGCH-------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif TTGTKTGTKTKTVTGVGGRWSDYYYRGRYCWWHGCGTYSKCGK VDBHMAGGTCACCCTGACCY TTGTKTGTKBDBVHRGGKVWSBBTBASVYCWWHGCGTYSKCGK Direction: Forward Position #: 10 Overlap #: 20 Alignment: TTGTKTGTKTKTVTGVGGRWSDYYYRGRYCWWHGCGTYSKCGK ---------VDBHMAGGTCACCCTGACCY-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Reverse Complement YCGYSMACGCHWWGMVSTBABBSWVYCCKDVVHVRACARACAA MGCCCCCTGMCA MGCCCCCKBVCACGCHWWGMVSTBABBSWVYCCKDVVHVRACARACAA Direction: Forward Position #: 6 Overlap #: 7 Alignment: -----YCGYSMACGCHWWGMVSTBABBSWVYCCKDVVHVRACARACAA MGCCCCCTGMCA------------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 Combined Motif Original Motif Reverse Complement MGCCCCCKBVCACGCHWWGMVSTBABBSWVYCCKDVVHVRACARACAA GCCYCMCCCD MGCCCCCKBVCACGCHWWGMVSTBAGCCTCMCCCDVVHVRACARACAA Direction: Forward Position #: 26 Overlap #: 10 Alignment: MGCCCCCKBVCACGCHWWGMVSTBABBSWVYCCKDVVHVRACARACAA -------------------------GCCYCMCCCD------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Reverse Complement MGCCCCCKBVCACGCHWWGMVSTBAGCCTCMCCCDVVHVRACARACAA TGMYCTTTGBCCK MGCCCCCKBVCACGCHWWGMVSTBAGCCTSMCCYTTVBHVDCARACAA Direction: Forward Position #: 29 Overlap #: 13 Alignment: MGCCCCCKBVCACGCHWWGMVSTBAGCCTCMCCCDVVHVRACARACAA ----------------------------TGMYCTTTGBCCK------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 10 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 EWSR1-FLI1 Reverse Complement Original Motif AAAAAAACAAARRA GGAAGGAAGGAAGGAAGG GGAARRAARSAARGAAGG Direction: Forward Position #: 3 Overlap #: 14 Alignment: --AAAAAAACAAARRA-- GGAAGGAAGGAAGGAAGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 11 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 11 Motif 9 Original Motif Original Motif CAYACACACACACA CACACAVRCACACA CACACACACACACA Direction: Forward Position #: 1 Overlap #: 14 Alignment: CAYACACACACACA CACACAVRCACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Original Motif CACACACACACACA CCCCMAAMCAMCCMCMMMCV CCCCMAAMCAMCCMCACACACACACACA Direction: Forward Position #: 15 Overlap #: 6 Alignment: --------------CACACACACACACA CCCCMAAMCAMCCMCMMMCV-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 10 Reverse Complement Original Motif TGTGTGTGTGTGTGRGGRTGRTTYGGGG TKKTTTGTTTTTTT TTGTKTGTKTKTKTGRGGRTGRTTYGGGG Direction: Forward Position #: 2 Overlap #: 13 Alignment: -TGTGTGTGTGTGTGRGGRTGRTTYGGGG TKKTTTGTTTTTTT--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Reverse Complement CCCCMAAMCAMCCMCARAYARACARACAA MGCCCCCTGMCA MGCCCCCWRMCAMCCMCARAYARACARACAA Direction: Forward Position #: 3 Overlap #: 10 Alignment: --CCCCMAAMCAMCCMCARAYARACARACAA MGCCCCCTGMCA------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Reverse Complement MGCCCCCWRMCAMCCMCARAYARACARACAA YCGCCCACGCH YCGCCCMCDMMCAMCCMCARAYARACARACAA Direction: Forward Position #: 2 Overlap #: 10 Alignment: -MGCCCCCWRMCAMCCMCARAYARACARACAA YCGCCCACGCH--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Original Motif YCGCCCMCDMMCAMCCMCARAYARACARACAA VDBHMAGGTCACCCTGACCY VDBHYMGSYCACVCWSACCYMCARAYARACARACAA Direction: Forward Position #: 5 Overlap #: 16 Alignment: ----YCGCCCMCDMMCAMCCMCARAYARACARACAA VDBHMAGGTCACCCTGACCY---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 Combined Motif Original Motif Reverse Complement VDBHYMGSYCACVCWSACCYMCARAYARACARACAA GCCYCMCCCD VDBHYMGSYCACVBYCHCCCCCARAYARACARACAA Direction: Forward Position #: 14 Overlap #: 10 Alignment: VDBHYMGSYCACVCWSACCYMCARAYARACARACAA -------------GCCYCMCCCD------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Reverse Complement Reverse Complement TTGTKTGTKTKTKTGGGGGHGKBVGTGKSCYKDBHV GGGGGYGGGG TTGTKTGTKTKTKTGGGGGHGKBGGKGGBSGGGBHV Direction: Forward Position #: 24 Overlap #: 10 Alignment: TTGTKTGTKTKTKTGGGGGHGKBVGTGKSCYKDBHV -----------------------GGGGGYGGGG--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 7 Combined Motif Reverse Complement Original Motif VDBCCCSBCCRCCBYCHCCCCCARAYARACARACAA CCCRCCCC VDBCCCSBCCRCCBCCCVCCCCARAYARACARACAA Direction: Forward Position #: 15 Overlap #: 8 Alignment: VDBCCCSBCCRCCBYCHCCCCCARAYARACARACAA --------------CCCRCCCC-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Original Motif Original Motif VDBCCCSBCCRCCBCCCVCCCCARAYARACARACAA VBACGTGV VBVCSTGBCCRCCBCCCVCCCCARAYARACARACAA Direction: Forward Position #: 1 Overlap #: 8 Alignment: VDBCCCSBCCRCCBCCCVCCCCARAYARACARACAA VBACGTGV---------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 12 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Pax5 Original Motif Original Motif BBVGCCBVGGCCTV DGVBCABTGDWGCGKRRCSR DGVBVDSYGVGGCSTRRCSR Direction: Backward Position #: 5 Overlap #: 14 Alignment: --BBVGCCBVGGCCTV---- DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Reverse Complement DGVBVDSYGVGGCSTRRCSR BAGGYCABHBTGACCKHV VRGGHVVYBVKGMCYDDCSR Direction: Forward Position #: 1 Overlap #: 18 Alignment: DGVBVDSYGVGGCSTRRCSR BAGGYCABHBTGACCKHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Reverse Complement VRGGHVVYBVKGMCYDDCSR MGGTCAGGGTGACCTRDBHV VRGGHVVYBVKGHCHBDVBGACCTRDBHV Direction: Forward Position #: 10 Overlap #: 11 Alignment: VRGGHVVYBVKGMCYDDCSR--------- ---------MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Reverse Complement Reverse Complement VDBHMAGGTCVVHBHGHCYBBKBVDCCKV CKGGDTBDMMCTGG VDBHMAGGTCDGGBTGHCHCBGGVDCCKV Direction: Forward Position #: 10 Overlap #: 14 Alignment: VDBHMAGGTCVVHBHGHCYBBKBVDCCKV ---------CKGGDTBDMMCTGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Reverse Complement Reverse Complement VRGGHVCCVGDGHCAVCCDGACCTRDBHV GYRYCCMTKGGYRSC VRGGBVYCCVWGGGHRSCDGACCTRDBHV Direction: Forward Position #: 4 Overlap #: 15 Alignment: VRGGHVCCVGDGHCAVCCDGACCTRDBHV ---GYRYCCMTKGGYRSC----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Reverse Complement VRGGBVYCCVWGGGHRSCDGACCTRDBHV CCCCCTTGGGCCCC VRGGCCCCCBWGGGCCCCDGACCTRDBHV Direction: Forward Position #: 5 Overlap #: 14 Alignment: VRGGBVYCCVWGGGHRSCDGACCTRDBHV ----CCCCCTTGGGCCCC----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Reverse Complement Reverse Complement VDBHMAGGTCDGGGGCCCWVGGGGGCCKV GGYGCTGTCCATGGTGCTGAA GVHBCWGKYCDKGGKSCYRARGGGGCCKV Direction: Forward Position #: 1 Overlap #: 21 Alignment: VDBHMAGGTCDGGGGCCCWVGGGGGCCKV GGYGCTGTCCATGGTGCTGAA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement GVHBCWGKYCDKGGKSCYRARGGGGCCKV VRVDGGHACAVDDKGTHCTDWH GVHBCWGKYCDKGGKSCBRVDGGDRCMBDDKGTHCTDWH Direction: Forward Position #: 18 Overlap #: 12 Alignment: GVHBCWGKYCDKGGKSCYRARGGGGCCKV---------- -----------------VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif HWDAGHACRHHBYGKHCCHBMVGSRCCYDGKRCWGBDVC BTRGGDCARAGGKCA HWDAGHACRHHBYGKHCCHBMVGSRCYVDGKVMARGGBCA Direction: Forward Position #: 26 Overlap #: 14 Alignment: HWDAGHACRHHBYGKHCCHBMVGSRCCYDGKRCWGBDVC- -------------------------BTRGGDCARAGGKCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Reverse Complement Original Motif TGVCCKTYVYCHBKGKSCBRVDGGDRCMBDDKGTHCTDWH RGKTCABVVRGAGGTCA TGVCCKTYVYCVGKKBACVRVVRGKDCABDDKGTHCTDWH Direction: Forward Position #: 12 Overlap #: 17 Alignment: TGVCCKTYVYCHBKGKSCBRVDGGDRCMBDDKGTHCTDWH -----------RGKTCABVVRGAGGTCA------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 13 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Ar Original Motif Original Motif GSMMCCYARGGKKKC HWDAGHACRHHVTGTHCCHVMV HWDRGMACMYHRKGTDCCHVMV Direction: Backward Position #: 5 Overlap #: 15 Alignment: ---GSMMCCYARGGKKKC---- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement HWDRGMACMYHRKGTDCCHVMV MSGKKRCGCWDCABTGBBCD HWDRGMACMYMVGGKDCVCDHCABTGBBCD Direction: Forward Position #: 11 Overlap #: 12 Alignment: HWDRGMACMYHRKGTDCCHVMV-------- ----------MSGKKRCGCWDCABTGBBCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Reverse Complement Reverse Complement HGVBCABTGHDGVGDRCCVYKRGTYCMDWH GGYGCTGTCCATGGTGCTGAA HGVBCABTGDDBGSTRYCCHKGGTBCHKAH Direction: Forward Position #: 10 Overlap #: 21 Alignment: HGVBCABTGHDGVGDRCCVYKRGTYCMDWH ---------GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Reverse Complement Reverse Complement HTYHGBACCRHGGMMASCBHHCABTGBBCD TGAACKCBWTGACCC TGAACKHBHKGACCMHGGMMASCBHHCABTGBBCD Direction: Forward Position #: 6 Overlap #: 10 Alignment: -----HTYHGBACCRHGGMMASCBHHCABTGBBCD TGAACKCBWTGACCC-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif HGVBCABTGDDBGSTRYCCHYGGTCYHBDRGTTCA GGGGCCCAAGGGGG GGGGCBCAVKGGGGGSTRYCCHYGGTCYHBDRGTTCA Direction: Forward Position #: 3 Overlap #: 12 Alignment: --HGVBCABTGDDBGSTRYCCHYGGTCYHBDRGTTCA GGGGCCCAAGGGGG----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Original Motif TGAACKHBHKGACCMHGGMMASCCCCCYBTGBGCCCC BBVGCCBVGGCCTV TGAACKHBHKGACCMHGGMMASCBCCSCYBVGGCCYC Direction: Forward Position #: 24 Overlap #: 14 Alignment: TGAACKHBHKGACCMHGGMMASCCCCCYBTGBGCCCC -----------------------BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Reverse Complement GMGGCCVVKGSGGBGSTRYCCHYGGTCYHBDRGTTCA MGGTCAGGGTGACCTRDBHV GMGGCCVVKGSGGBGSTRYCCHHGGTCHDBDDGWYCDRDBHV Direction: Forward Position #: 23 Overlap #: 15 Alignment: GMGGCCVVKGSGGBGSTRYCCHYGGTCYHBDRGTTCA----- ----------------------MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Original Motif VDBHMDGMWCDHBHHGACCDHGGMMASCBCCSCYBVGGCCYC CCCCMAAMCAMCCMCMMMCV VDBHMDGMMCCMMMHSACCVHSVMMVVCBCCSCYBVGGCCYC Direction: Forward Position #: 8 Overlap #: 20 Alignment: VDBHMDGMWCDHBHHGACCDHGGMMASCBCCSCYBVGGCCYC -------CCCCMAAMCAMCCMCMMMCV--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Original Motif Reverse Complement VDBHMDGMMCCMMMHSACCVHSVMMVVCBCCSCYBVGGCCYC MGCCCCCTGMCA VDBHMDGMMCCMMDCCMCCHVMCAMVVCBCCSCYBVGGCCYC Direction: Forward Position #: 13 Overlap #: 12 Alignment: VDBHMDGMMCCMMMHSACCVHSVMMVVCBCCSCYBVGGCCYC ------------MGCCCCCTGMCA------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Original Motif VDBHMDGMMCCMMDCCMCCHVMCAMVVCBCCSCYBVGGCCYC CCAGYYHVADCCRG VDBHMDGMMCCMMDCCMCCHVMCAMVVCCVGBYYDRGSCVBC Direction: Forward Position #: 28 Overlap #: 14 Alignment: VDBHMDGMMCCMMDCCMCCHVMCAMVVCBCCSCYBVGGCCYC ---------------------------CCAGYYHVADCCRG- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 14 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZEB1 RORA_1 Original Motif Reverse Complement CACCTD TGACCTDVWT TSACCTDVWT Direction: Backward Position #: 4 Overlap #: 6 Alignment: -CACCTD--- TGACCTDVWT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif TSACCTDVWT TTCAGCACCATGGACAGCKCC TTCAKSACCWDGRWCAGCKCC Direction: Forward Position #: 5 Overlap #: 10 Alignment: ----TSACCTDVWT------- TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Esrrb Combined Motif Original Motif Reverse Complement TTCAKSACCWDGRWCAGCKCC CACGTG TTCAKCACSTDGRWCAGCKCC Direction: Forward Position #: 6 Overlap #: 6 Alignment: TTCAKSACCWDGRWCAGCKCC -----CACGTG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Arnt Combined Motif Original Motif Reverse Complement TTCAKCACSTDGRWCAGCKCC CACGTG TTCAKCACGTGGRWCAGCKCC Direction: Forward Position #: 6 Overlap #: 6 Alignment: TTCAKCACSTDGRWCAGCKCC -----CACGTG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Original Motif Original Motif TTCAKCACGTGGRWCAGCKCC AAAGGTCAAAGGTCAAC AAAGGTCAAAGGTCADCACGTGGRWCAGCKCC Direction: Forward Position #: 12 Overlap #: 6 Alignment: -----------TTCAKCACGTGGRWCAGCKCC AAAGGTCAAAGGTCAAC--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Reverse Complement Reverse Complement GGYGCTGWMCCACGTGDTGACCTTTGACCTTT VCACGTBV VCACGKHVCTGWMCCACGTGDTGACCTTTGACCTTT Direction: Forward Position #: 5 Overlap #: 4 Alignment: ----GGYGCTGWMCCACGTGDTGACCTTTGACCTTT VCACGTBV---------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Original Motif AAAGGTCAAAGGTCADCACGTGGRWCAGVDRCGTGV TGYCAGGGGGCR TGYCARRGGKCAAAGGTCADCACGTGGRWCAGVDRCGTGV Direction: Forward Position #: 5 Overlap #: 8 Alignment: ----AAAGGTCAAAGGTCADCACGTGGRWCAGVDRCGTGV TGYCAGGGGGCR---------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Original Motif TGYCARRGGKCAAAGGTCADCACGTGGRWCAGVDRCGTGV BTRGGDCARAGGKCA BTRKGBCARRGGKCAAAGGTCADCACGTGGRWCAGVDRCGTGV Direction: Forward Position #: 4 Overlap #: 12 Alignment: ---TGYCARRGGKCAAAGGTCADCACGTGGRWCAGVDRCGTGV BTRGGDCARAGGKCA---------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Reverse Complement Reverse Complement VCACGKHVCTGWMCCACGTGDTGACCTTTGRCCKKTGVCYKAB ACCACGTGSTM ASCACGTGSYTGWMCCACGTGDTGACCTTTGRCCKKTGVCYKAB Direction: Forward Position #: 2 Overlap #: 10 Alignment: -VCACGKHVCTGWMCCACGTGDTGACCTTTGRCCKKTGVCYKAB ACCACGTGSTM--------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR4A2 Original Motif Original Motif ASCACGTGSYTGWMCCACGTGDTGACCTTTGRCCKKTGVCYKAB AAGGTCAC AAGRBCACGTGSYTGWMCCACGTGDTGACCTTTGRCCKKTGVCYKAB Direction: Forward Position #: 4 Overlap #: 5 Alignment: ---ASCACGTGSYTGWMCCACGTGDTGACCTTTGRCCKKTGVCYKAB AAGGTCAC--------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 15 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TFAP2A Zfx Reverse Complement Original Motif SCMVBBGGC BBVGCCBVGGCCTV BBVSCCBVGGSCTV Direction: Backward Position #: 3 Overlap #: 9 Alignment: ---SCMVBBGGC-- BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Original Motif Reverse Complement BBVSCCBVGGSCTV CCCCCTTGGGCCCC CCCCCYHVGGCCYC Direction: Forward Position #: 1 Overlap #: 14 Alignment: BBVSCCBVGGSCTV CCCCCTTGGGCCCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Reverse Complement Reverse Complement GMGGCCVHKGGGGG GYRYCCMTKGGYRSC GHGBCCMWKGGBGSC Direction: Forward Position #: 1 Overlap #: 14 Alignment: GMGGCCVHKGGGGG- GYRYCCMTKGGYRSC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Reverse Complement GSCBCCYWRGGBCDC MGGTCAGGGTGACCTRDBHV MGGTCAGGGTGACCTRGSHBCCYWRGGBCDC Direction: Forward Position #: 17 Overlap #: 4 Alignment: ----------------GSCBCCYWRGGBCDC MGGTCAGGGTGACCTRDBHV----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif MGGTCAGGGTGACCTRGSHBCCYWRGGBCDC VHRGGTCABDBTGMCCTB MGGTCAVDRKGWCMBDDBVHCCYDRGGBCDC Direction: Forward Position #: 7 Overlap #: 18 Alignment: MGGTCAGGGTGACCTRGSHBCCYWRGGBCDC ------VHRGGTCABDBTGMCCTB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn Combined Motif Reverse Complement Original Motif GHGBCCMDMGGHVVHHVYGWCRMHVTGACCY HSCACGTGGC GHGBCCMDMGGHSCACGYGDCRMHVTGACCY Direction: Forward Position #: 12 Overlap #: 10 Alignment: GHGBCCMDMGGHVVHHVYGWCRMHVTGACCY -----------HSCACGTGGC---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif MGGTCAVDRKGHCMCGTGSDCCYDRGGBCDC DGVBCABTGDWGCGKRRCSR MGGTCAVDRKGHCMCGDGVDCMBBGGGGCGBRRCSR Direction: Forward Position #: 17 Overlap #: 15 Alignment: MGGTCAVDRKGHCMCGTGSDCCYDRGGBCDC----- ----------------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Original Motif MGGTCAVDRKGHCMCGDGVDCMBBGGGGCGBRRCSR RGKTCABVVRGAGGTCA MGGTCAVRGKKCMHVGDGVGBHCAGGGGCGBRRCSR Direction: Forward Position #: 8 Overlap #: 17 Alignment: MGGTCAVDRKGHCMCGDGVDCMBBGGGGCGBRRCSR -------RGKTCABVVRGAGGTCA------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Myc Combined Motif Reverse Complement Original Motif MSGKKBCGCCCCTGHBCBCDCVHYGRYCMVTGACCY VGCACGTGGH MSGKKBCGCCCCTGHSCACGYGBYGRYCMVTGACCY Direction: Forward Position #: 15 Overlap #: 10 Alignment: MSGKKBCGCCCCTGHBCBCDCVHYGRYCMVTGACCY --------------VGCACGTGGH------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Original Motif MSGKKBCGCCCCTGHSCACGYGBYGRYCMVTGACCY CCAGYYHVADCCRG MSGKKBCGCCVSTBHVMDCBHGBYGRYCMVTGACCY Direction: Forward Position #: 9 Overlap #: 14 Alignment: MSGKKBCGCCCCTGHSCACGYGBYGRYCMVTGACCY --------CCAGYYHVADCCRG-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 16 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 RREB1 Reverse Complement Reverse Complement GGGGGYGGGG BGRRRGRGGRTGRTTYGGGG BGGGGGVGGGKGRTTYGGGG Direction: Forward Position #: 2 Overlap #: 10 Alignment: -GGGGGYGGGG--------- BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif BGGGGGVGGGKGRTTYGGGG BBVGCCBVGGCCTV BGGBGGSSGRGGSYTBGGGG Direction: Forward Position #: 3 Overlap #: 14 Alignment: BGGGGGVGGGKGRTTYGGGG --BBVGCCBVGGCCTV---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Original Motif BGGBGGSSGRGGSYTBGGGG GGGGCCCAAGGGGG BGGGGSCVDRGGGSKBGGGG Direction: Forward Position #: 2 Overlap #: 14 Alignment: BGGBGGSSGRGGSYTBGGGG -GGGGCCCAAGGGGG----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Original Motif BGGGGSCVDRGGGSKBGGGG BTRGGDCARAGGKCA BGGKGGSBVARRGGKBRGGG Direction: Forward Position #: 3 Overlap #: 15 Alignment: BGGGGSCVDRGGGSKBGGGG --BTRGGDCARAGGKCA--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 Combined Motif Reverse Complement Reverse Complement CCCMBRCCMMTVBSCCYCCB GCCYCMCCCD CCCMBRSCCYYVCCCHYCCB Direction: Forward Position #: 7 Overlap #: 10 Alignment: CCCMBRCCMMTVBSCCYCCB ------GCCYCMCCCD---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Egr1 Combined Motif Reverse Complement Original Motif BGGKHGGGBKKGGSKBRGGG HGCGTGGGCGK BGGKHGSGTGGGSGKBRGGG Direction: Forward Position #: 5 Overlap #: 11 Alignment: BGGKHGGGBKKGGSKBRGGG ----HGCGTGGGCGK----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif BGGKHGSGTGGGSGKBRGGG DGVBCABTGDWGCGKRRCSR BGGKHGSGTGGGBSDBDGRRGCGKRRCSR Direction: Forward Position #: 10 Overlap #: 11 Alignment: BGGKHGSGTGGGSGKBRGGG--------- ---------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_5-13 Combined Motif Original Motif Original Motif BGGKHGSGTGGGBSDBDGRRGCGKRRCSR BKAGGGGDAD BGGKHGSGTBGAGGGGDRRRGCGKRRCSR Direction: Forward Position #: 10 Overlap #: 10 Alignment: BGGKHGSGTGGGBSDBDGRRGCGKRRCSR ---------BKAGGGGDAD---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Reverse Complement Reverse Complement MSGKKRCGCMMMHCCCCTCBACSCHYCCB MGCCCCCTGMCA MSGKKRCGCMVCCCCCHKMCACSCHYCCB Direction: Forward Position #: 10 Overlap #: 12 Alignment: MSGKKRCGCMMMHCCCCTCBACSCHYCCB ---------MGCCCCCTGMCA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif EWSR1-FLI1 Original Motif Original Motif MSGKKRCGCMVCCCCCHKMCACSCHYCCB GGAAGGAAGGAAGGAAGG GGAAGGAAGGAAGGAAGGKRCGCMVCCCCCHKMCACSCHYCCB Direction: Forward Position #: 15 Overlap #: 4 Alignment: --------------MSGKKRCGCMVCCCCCHKMCACSCHYCCB GGAAGGAAGGAAGGAAGG------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 17 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRAVDR Ar Reverse Complement Original Motif TGAACKCBWTGACCC HWDAGHACRHHVTGTHCCHVMV HWDDGAACDCBHTGWCCCHVMV Direction: Backward Position #: 5 Overlap #: 15 Alignment: ---TGAACKCBWTGACCC---- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement VRVDGGGWCAHBGHGTTCDDWH BAGGYCABHBTGACCKHV VRVBRGGWCABBBTGWYCKHDH Direction: Forward Position #: 4 Overlap #: 18 Alignment: VRVDGGGWCAHBGHGTTCDDWH ---BAGGYCABHBTGACCKHV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Reverse Complement Original Motif HDHRGKWCABBBTGWCCKBVMV RGKTCABVVRGAGGTCA HDHRGKTCABVDDGASSTCAMV Direction: Forward Position #: 4 Overlap #: 17 Alignment: HDHRGKWCABBBTGWCCKBVMV ---RGKTCABVVRGAGGTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif HDHRGKTCABVDDGASSTCAMV VDBHMAGGTCACCCTGACCY HDHRGKTCABVVDSHVVKGDCACCCTGACCY Direction: Forward Position #: 12 Overlap #: 11 Alignment: HDHRGKTCABVDDGASSTCAMV--------- -----------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Reverse Complement Original Motif MGGTCAGGGTGDCYBVHSDVVBTGAYCKHDH GSMMCCYARGGKKKC GSMVSYCARGGKKDCYBVHSDVVBTGAYCKHDH Direction: Forward Position #: 3 Overlap #: 13 Alignment: --MGGTCAGGGTGDCYBVHSDVVBTGAYCKHDH GSMMCCYARGGKKKC------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Original Motif HDHRGKTCABVVDSHVVKGHYRCCMTGKSVYSC AAAGGTCAAAGGTCAAC AAAGGTCAAAGGTCAHSVDSHVVKGHYRCCMTGKSVYSC Direction: Forward Position #: 7 Overlap #: 11 Alignment: ------HDHRGKTCABVVDSHVVKGHYRCCMTGKSVYSC AAAGGTCAAAGGTCAAC---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Reverse Complement Reverse Complement GSMVSYCARGGKKDCYBVHSDVSHTGACCTTTGACCTTT CCCCCTTGGGCCCC GSCCCCCWDGGGSCCCBVHSDVSHTGACCTTTGACCTTT Direction: Forward Position #: 3 Overlap #: 14 Alignment: GSMVSYCARGGKKDCYBVHSDVSHTGACCTTTGACCTTT --CCCCCTTGGGCCCC----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Reverse Complement GSCCCCCWDGGGSCCCBVHSDVSHTGACCTTTGACCTTT TGRCCTKTGHCCKAB GSCCCCCWDGGGSCCCBVHSDVSHTGACCTTTGACCKDB Direction: Forward Position #: 25 Overlap #: 15 Alignment: GSCCCCCWDGGGSCCCBVHSDVSHTGACCTTTGACCTTT ------------------------TGRCCTKTGHCCKAB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif GSCCCCCWDGGGSCCCBVHSDVSHTGACCTTTGACCKDB RGGBCAAAGKYCA GSCCCCCWDGGGSCVSBBYMAAGKTSACCTTTGACCKDB Direction: Forward Position #: 15 Overlap #: 13 Alignment: GSCCCCCWDGGGSCCCBVHSDVSHTGACCTTTGACCKDB --------------RGGBCAAAGKYCA------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Original Motif Reverse Complement GSCCCCCWDGGGSCVSBBYMAAGKTSACCTTTGACCKDB AKGYYCAAAGRTCA GSCCCCCWDGGGSVVGBBCAAAGDTCACCTTTGACCKDB Direction: Forward Position #: 14 Overlap #: 14 Alignment: GSCCCCCWDGGGSCVSBBYMAAGKTSACCTTTGACCKDB -------------AKGYYCAAAGRTCA------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 18 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 ESR1 Reverse Complement Reverse Complement BGRRRGRGGRTGRTTYGGGG MGGTCAGGGTGACCTRDBHV BVGGDSAGGGTGRYYTGGGVV Direction: Backward Position #: 2 Overlap #: 19 Alignment: BGRRRGRGGRTGRTTYGGGG- -MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement BVGGDSAGGGTGRYYTGGGVV VRVDGGHACAVDDKGTHCTDWH BVGGDVDGGDWSABBTKGKDCTDWH Direction: Forward Position #: 4 Overlap #: 18 Alignment: BVGGDSAGGGTGRYYTGGGVV---- ---VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif BVGGDVDGGDWSABBTKGKDCTDWH VHRGGTCABDBTGMCCTB BVGGDVDRGGTCABBBKGHHCTDWH Direction: Forward Position #: 6 Overlap #: 18 Alignment: BVGGDVDGGDWSABBTKGKDCTDWH -----VHRGGTCABDBTGMCCTB-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement BVGGDVDRGGTCABBBKGHHCTDWH MSGKKRCGCWDCABTGBBCD BVGGDVDRGGTCASGKKRHVCTDHHBTGBBCD Direction: Forward Position #: 13 Overlap #: 13 Alignment: BVGGDVDRGGTCABBBKGHHCTDWH------- ------------MSGKKRCGCWDCABTGBBCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Reverse Complement HGVBCABHDDAGVDMRRCSTGACCMDVHCCVB CCCCCTTGGGCCCC CCCCCTWGGGCCCCDDAGVDMRRCSTGACCMDVHCCVB Direction: Forward Position #: 7 Overlap #: 8 Alignment: ------HGVBCABHDDAGVDMRRCSTGACCMDVHCCVB CCCCCTTGGGCCCC------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 9 Reverse Complement Reverse Complement BVGGDVDRGGTCASGKKRHVCTDHGGGGCCCWAGGGGG TGTGTGKVTGTGTG TGTGKGKVWGKGTSASGKKRHVCTDHGGGGCCCWAGGGGG Direction: Forward Position #: 3 Overlap #: 12 Alignment: --BVGGDVDRGGTCASGKKRHVCTDHGGGGCCCWAGGGGG TGTGTGKVTGTGTG-------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 11 Combined Motif Original Motif Reverse Complement TGTGKGKVWGKGTSASGKKRHVCTDHGGGGCCCWAGGGGG TGTGTGTGTGTKTG TGTGKGKVTGTGTGWGKGKGTGCTDHGGGGCCCWAGGGGG Direction: Forward Position #: 9 Overlap #: 14 Alignment: TGTGKGKVWGKGTSASGKKRHVCTDHGGGGCCCWAGGGGG --------TGTGTGTGTGTKTG------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Reverse Complement Reverse Complement CCCCCTWGGGCCCCDDAGCACRCRCWCACACAVRCRCACA TGACCTCKVVBTGAYCK TGMCCYCTHVBKSACCKDAGCACRCRCWCACACAVRCRCACA Direction: Forward Position #: 3 Overlap #: 15 Alignment: --CCCCCTWGGGCCCCDDAGCACRCRCWCACACAVRCRCACA TGACCTCKVVBTGAYCK------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Reverse Complement TGTGKGKVTGTGTGWGKGKGTGCTDYGGTSRBVDAGKGGRCA TGRCCTKTGHCCKAB TGTGKGKVTGTGTGDSYKKKBBCYKHGGTSRBVDAGKGGRCA Direction: Forward Position #: 13 Overlap #: 15 Alignment: TGTGKGKVTGTGTGWGKGKGTGCTDYGGTSRBVDAGKGGRCA ------------TGRCCTKTGHCCKAB--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Reverse Complement TGTGKGKVTGTGTGDSYKKKBBCYKHGGTSRBVDAGKGGRCA CKGGDTBDMMCTGG TGTGKGKVTGTGTGDSYKKKBBCYCDGGTBDBMHMKGGGRCA Direction: Forward Position #: 25 Overlap #: 14 Alignment: TGTGKGKVTGTGTGDSYKKKBBCYKHGGTSRBVDAGKGGRCA ------------------------CKGGDTBDMMCTGG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 19 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Ar Reverse Complement Reverse Complement GGYGCTGTCCATGGTGCTGAA VRVDGGHACAVDDKGTHCTDWH VGVHGSTRYMCDDKGTBCTKAH Direction: Backward Position #: 1 Overlap #: 21 Alignment: -GGYGCTGTCCATGGTGCTGAA VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif VGVHGSTRYMCDDKGTBCTKAH DGVBCABTGDWGCGKRRCSR VGVHGSTRYMCDDDGYDCTGADGCGKRRCSR Direction: Forward Position #: 12 Overlap #: 11 Alignment: VGVHGSTRYMCDDKGTBCTKAH--------- -----------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif MSGKKRCGCDTCAGDMCHHDGRKKASCDVCV VDBHMAGGTCACCCTGACCY MSGKKRCGCDTCAGDMCVHBVVDGRBCAVCCTGACCY Direction: Forward Position #: 18 Overlap #: 14 Alignment: MSGKKRCGCDTCAGDMCHHDGRKKASCDVCV------ -----------------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement MGGTCAGGVTGBMCHVVBDVGYDCTGADGCGKRYCSR BAGGYCABHBTGACCKHV MGGTCAGGVTGBMCHVVBHGGYVMYBVTGMSYDHCSR Direction: Forward Position #: 18 Overlap #: 18 Alignment: MGGTCAGGVTGBMCHVVBDVGYDCTGADGCGKRYCSR -----------------BAGGYCABHBTGACCKHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif MGGTCAGGVTGBMCHVVBHGGYVMYBVTGMSYDHCSR RGGBCAAAGKYCA MGGTCAGGVTGBMCHVVBHGGYVVKDBYRARGKYCVR Direction: Forward Position #: 24 Overlap #: 13 Alignment: MGGTCAGGVTGBMCHVVBHGGYVMYBVTGMSYDHCSR -----------------------RGGBCAAAGKYCA- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Reverse Complement MGGTCAGGVTGBMCHVVBHGGYVVKDBYRARGKYCVR TGRCCTKTGHCCKAB MGGTCAGGVTGBMCHVVBHGGYVHGVCCKDDGBCCDRB Direction: Forward Position #: 24 Overlap #: 14 Alignment: MGGTCAGGVTGBMCHVVBHGGYVVKDBYRARGKYCVR- -----------------------TGRCCTKTGHCCKAB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Original Motif MGGTCAGGVTGBMCHVVBHGGYVHGVCCKDDGBCCDRB CCAGYYHVADCCRG MGGTCAGGVTGBMCHVVBHGGYVCSRSYDHDVDCCDGB Direction: Forward Position #: 24 Overlap #: 14 Alignment: MGGTCAGGVTGBMCHVVBHGGYVHGVCCKDDGBCCDRB -----------------------CCAGYYHVADCCRG- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Original Motif BCDGGHVDHDKSKSGVMCCHBVVDGRBCAVCCTGACCY BBVGCCBVGGCCTV BCDGGHVDHDKSKSGVMCCHBVVDGVBCDSCBHGRCCTV Direction: Forward Position #: 26 Overlap #: 13 Alignment: BCDGGHVDHDKSKSGVMCCHBVVDGRBCAVCCTGACCY- -------------------------BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Reverse Complement Reverse Complement VAGGMCHBGSHGBVCHVVBHGGYVCSRSYDHDVDCCDGB TGAACKCBWTGACCC TGAACKCVAKGACCCGSHGBVCHVVBHGGYVCSRSYDHDVDCCDGB Direction: Forward Position #: 8 Overlap #: 8 Alignment: -------VAGGMCHBGSHGBVCHVVBHGGYVCSRSYDHDVDCCDGB TGAACKCBWTGACCC------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Reverse Complement TGAACKCVAKGACCCGSHGBVCHVVBHGGYVCSRSYDHDVDCCDGB TGACCTCKVVBTGAYCK TGAACKCVAKGACCCGSHGBVCHVVBHKGHCCYVKHBBTGACCKGB Direction: Forward Position #: 28 Overlap #: 17 Alignment: TGAACKCVAKGACCCGSHGBVCHVVBHGGYVCSRSYDHDVDCCDGB ---------------------------TGACCTCKVVBTGAYCK-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 20 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA NR1H2RXRA Original Motif Original Motif BTRGGDCARAGGKCA AAAGGTCAAAGGTCAAC VDRGGTCAAAGGTCAAC Direction: Backward Position #: 3 Overlap #: 15 Alignment: BTRGGDCARAGGKCA-- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Original Motif VDRGGTCAAAGGTCAAC RGKTCABVVRGAGGTCA RGDTVRGBSARAGGTCAAC Direction: Forward Position #: 3 Overlap #: 15 Alignment: --VDRGGTCAAAGGTCAAC RGKTCABVVRGAGGTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Original Motif GTTGACCTKTSVCKVAHCK VHRGGTCABDBTGMCCTB GTTDASSTCWBVBTGACCTB Direction: Forward Position #: 3 Overlap #: 17 Alignment: GTTGACCTKTSVCKVAHCK- --VHRGGTCABDBTGMCCTB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement GTTDASSTCWBVBTGACCTB VRVDGGHACAVDDKGTHCTDWH GTTDASSTCDVVBKGWMCHVDDKGTHCTDWH Direction: Forward Position #: 10 Overlap #: 11 Alignment: GTTDASSTCWBVBTGACCTB----------- ---------VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement HWDAGHACRHHVHGYWCYBVVDGASSTHAAC MSGKKRCGCWDCABTGBBCD HWDAGHACRHHVHGYWCBGBBDVRCBTCAVYGBBCD Direction: Forward Position #: 17 Overlap #: 15 Alignment: HWDAGHACRHHVHGYWCYBVVDGASSTHAAC----- ----------------MSGKKRCGCWDCABTGBBCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif HWDAGHACRHHVHGYWCBGBBDVRCBTCAVYGBBCD VDBHMAGGTCACCCTGACCY HWDAGHACRHHVHGYWCBGBBDBVCDKSHVHBYBYGACCY Direction: Forward Position #: 21 Overlap #: 16 Alignment: HWDAGHACRHHVHGYWCBGBBDVRCBTCAVYGBBCD---- --------------------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Original Motif HWDAGHACRHHVHGYWCBGBBDBVCDKSHVHBYBYGACCY CCCCMAAMCAMCCMCMMMCV CCHCARAMCAMCCHSHHMCVBBDBVCDKSHVHBYBYGACCY Direction: Forward Position #: 2 Overlap #: 19 Alignment: -HWDAGHACRHHVHGYWCBGBBDBVCDKSHVHBYBYGACCY CCCCMAAMCAMCCMCMMMCV--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Reverse Complement Reverse Complement MGGTCMBKBHVHSYDGBBHBBVGRHDSHGGRTGYTMTGDGG GGYGCTGTCCATGGTGCTGAA MGGTCMBKBHVHSYDGBGVHBCKGTCCHDGGTGCTVHRDGG Direction: Forward Position #: 18 Overlap #: 21 Alignment: MGGTCMBKBHVHSYDGBBHBBVGRHDSHGGRTGYTMTGDGG -----------------GGYGCTGTCCATGGTGCTGAA--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Original Motif Original Motif MGGTCMBKBHVHSYDGBGVHBCKGTCCHDGGTGCTVHRDGG TGAMCTTTGMMCYT MGGTCMBKBTGAMCTKTGVHCCTGTCCHDGGTGCTVHRDGG Direction: Forward Position #: 10 Overlap #: 14 Alignment: MGGTCMBKBHVHSYDGBGVHBCKGTCCHDGGTGCTVHRDGG ---------TGAMCTTTGMMCYT------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Reverse Complement CCHMHVAGCACCHHGGACAGGDBCARAGRTCABYBYGACCY CCCCCTTGGGCCCC CCCCHBWGSRCCCCGGACAGGDBCARAGRTCABYBYGACCY Direction: Forward Position #: 1 Overlap #: 14 Alignment: CCHMHVAGCACCHHGGACAGGDBCARAGRTCABYBYGACCY CCCCCTTGGGCCCC--------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 21 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Zfp423 Original Motif Original Motif GGGGCCCAAGGGGG GSMMCCYARGGKKKC GGSVCCYARGGGGGC Direction: Forward Position #: 1 Overlap #: 14 Alignment: GGGGCCCAAGGGGG- GSMMCCYARGGKKKC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Original Motif GCCCCCKTKGGVSCC CCCCMAAMCAMCCMCMMMCV GCCCCMHWVSRMCCCCMMMCV Direction: Forward Position #: 2 Overlap #: 14 Alignment: GCCCCCKTKGGVSCC------ -CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif BGRRRGGGGRKSVWHRGGGGC BTRGGDCARAGGKCA BBRGGGSRRRGGBHWRGGGGC Direction: Forward Position #: 1 Overlap #: 15 Alignment: BGRRRGGGGRKSVWHRGGGGC BTRGGDCARAGGKCA------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif BBRGGGSRRRGGBHWRGGGGC BBVGCCBVGGCCTV BBVVGGSVVRGGCCTGGGGGC Direction: Forward Position #: 3 Overlap #: 14 Alignment: BBRGGGSRRRGGBHWRGGGGC --BBVGCCBVGGCCTV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Reverse Complement Original Motif GCCCCCAGGCCKVVSCCVVBB CCAGYYHVADCCRG GCCCCCAGBYCBVDCCVGVBB Direction: Forward Position #: 5 Overlap #: 14 Alignment: GCCCCCAGGCCKVVSCCVVBB ----CCAGYYHVADCCRG--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Reverse Complement GCCCCCAGBYCBVDCCVGVBB TGACCTCKVVBTGAYCK GCCCCCWGDCCTVDCCVKSABCK Direction: Forward Position #: 7 Overlap #: 15 Alignment: GCCCCCAGBYCBVDCCVGVBB-- ------TGACCTCKVVBTGAYCK ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif RGBTSRBGGDVAGGDCWGGGGGC DGVBCABTGDWGCGKRRCSR RGBTSRBGGDVDGDBCAVKGRRSCGKRRCSR Direction: Forward Position #: 12 Overlap #: 12 Alignment: RGBTSRBGGDVAGGDCWGGGGGC-------- -----------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Original Motif Original Motif RGBTSRBGGDVDGDBCAVKGRRSCGKRRCSR GGGTCAWBGRGTTCA RGGTCAHVGRGTKCDCAVKGRRSCGKRRCSR Direction: Forward Position #: 1 Overlap #: 15 Alignment: RGBTSRBGGDVDGDBCAVKGRRSCGKRRCSR GGGTCAWBGRGTTCA---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif RGGTCAHVGRGTKCDCAVKGRRSCGKRRCSR RGGBCAAAGKYCA RGGTCAHVGRGDGBDCARRGKDSMGKRRCSR Direction: Forward Position #: 12 Overlap #: 13 Alignment: RGGTCAHVGRGTKCDCAVKGRRSCGKRRCSR -----------RGGBCAAAGKYCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Original Motif Reverse Complement RGGTCAHVGRGDGBDCARRGKDSMGKRRCSR AKGYYCAAAGRTCA ARGBTCAAVGRKCRBDCARRGKDSMGKRRCSR Direction: Forward Position #: 2 Overlap #: 13 Alignment: -RGGTCAHVGRGDGBDCARRGKDSMGKRRCSR AKGYYCAAAGRTCA------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 22 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 NR1H2RXRA Original Motif Reverse Complement TGAMCTTTGMMCYT GTTGACCTTTGACCTTT GTTGACCTTTGACCTTT Direction: Backward Position #: 2 Overlap #: 14 Alignment: --TGAMCTTTGMMCYT- GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Original Motif AAAGGTCAAAGGTCAAC BTRGGDCARAGGKCA VDRGGKCAAAGGTCAAC Direction: Forward Position #: 1 Overlap #: 15 Alignment: AAAGGTCAAAGGTCAAC BTRGGDCARAGGKCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Original Motif VDRGGKCAAAGGTCAAC RGKTCABVVRGAGGTCA RGDTVRDBSARAGGTCAAC Direction: Forward Position #: 3 Overlap #: 15 Alignment: --VDRGGKCAAAGGTCAAC RGKTCABVVRGAGGTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Original Motif GTTGACCTKTSBHKVAHCK VHRGGTCABDBTGMCCTB GTTDASSTCWBBBTGACCTB Direction: Forward Position #: 3 Overlap #: 17 Alignment: GTTGACCTKTSBHKVAHCK- --VHRGGTCABDBTGMCCTB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif BAGGTCABBBWGASSTHAAC TTCAGCACCATGGACAGCKCC TTCAGCACCHHGGWCAGBBHBASSTHAAC Direction: Forward Position #: 10 Overlap #: 12 Alignment: ---------BAGGTCABBBWGASSTHAAC TTCAGCACCATGGACAGCKCC-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif TTCAGCACCHHGGWCAGBBHBASSTHAAC DGVBCABTGDWGCGKRRCSR TTCAGCACCHHGGWCADVVBCASBKVARCGKRRCSR Direction: Forward Position #: 17 Overlap #: 13 Alignment: TTCAGCACCHHGGWCAGBBHBASSTHAAC------- ----------------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif TTCAGCACCHHGGWCADVVBCASBKVARCGKRRCSR RGGBCAAAGKYCA TTCAGCACCHHGGWCADVVBCAGBBCARMGKDVMSR Direction: Forward Position #: 22 Overlap #: 13 Alignment: TTCAGCACCHHGGWCADVVBCASBKVARCGKRRCSR ---------------------RGGBCAAAGKYCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Reverse Complement TTCAGCACCHHGGWCADVVBCAGBBCARMGKDVMSR VAGGCCBBGGCVBB TTCAGCACCHVRGRCMBBGBCVSBBCARMGKDVMSR Direction: Forward Position #: 11 Overlap #: 14 Alignment: TTCAGCACCHHGGWCADVVBCAGBBCARMGKDVMSR ----------VAGGCCBBGGCVBB------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif TTCAGCACCHVRGRCMBBGBCVSBBCARMGKDVMSR VDBHMAGGTCACCCTGACCY TTCAGCACCHVRGRCMBBGBVVBBBVRRHSDVVMBGACCY Direction: Forward Position #: 21 Overlap #: 16 Alignment: TTCAGCACCHVRGRCMBBGBCVSBBCARMGKDVMSR---- --------------------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Reverse Complement Original Motif MGGTCVRVVDSHMMBBBBVVBCBBRGMCKVHGGTGCTGAA GGGTCAWBGRGTTCA RGGTCADVGRGTYCHBBBVVBCBBRGMCKVHGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 15 Alignment: MGGTCVRVVDSHMMBBBBVVBCBBRGMCKVHGGTGCTGAA GGGTCAWBGRGTTCA------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 23 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_1-4 INSM1 Reverse Complement Reverse Complement TCCCCV MGCCCCCTGMCA MGYCCCCWGMCA Direction: Forward Position #: 3 Overlap #: 6 Alignment: --TCCCCV---- MGCCCCCTGMCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MZF1_5-13 Original Motif Reverse Complement MGYCCCCWGMCA BTHCCCCTYB HKYCCCCTBVCA Direction: Forward Position #: 1 Overlap #: 10 Alignment: MGYCCCCWGMCA BTHCCCCTYB-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Original Motif TGVBAGGGGKYD DGGGYGKGGC TGGGHGGGGBYD Direction: Forward Position #: 1 Overlap #: 10 Alignment: TGVBAGGGGKYD DGGGYGKGGC-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Original Motif Original Motif TGGGHGGGGBYD GGGGCCCAAGGGGG GGGGBSVDMGGGGGYD Direction: Forward Position #: 5 Overlap #: 10 Alignment: ----TGGGHGGGGBYD GGGGCCCAAGGGGG-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 8 Original Motif Original Motif GGGGBSVDMGGGGGYD CTGGGA CKGGGASVDMGGGGGYD Direction: Forward Position #: 2 Overlap #: 5 Alignment: -GGGGBSVDMGGGGGYD CTGGGA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Reverse Complement Original Motif HKCCCCCYDVSTCCCYG CCCCKCCCCC HKCCCCCBBCCYCCCYG Direction: Forward Position #: 4 Overlap #: 10 Alignment: HKCCCCCYDVSTCCCYG ---CCCCKCCCCC---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement CKGGGKGGBVGGGGGYD BGRRRGRGGRTGRTTYGGGG CGGGGGGGGRKGGKKYGGGG Direction: Forward Position #: 1 Overlap #: 17 Alignment: CKGGGKGGBVGGGGGYD--- BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NFKB1 Reverse Complement Original Motif CCCCMRYCCRMCCCCCCCCG GGGGRTTCCCC GGGGRTYCCCCRYCCRMCCCCCCCCG Direction: Forward Position #: 7 Overlap #: 5 Alignment: ------CCCCMRYCCRMCCCCCCCCG GGGGRTTCCCC--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Reverse Complement CGGGGGGGGRKGGKKGGGGKAKCCCC GGYGCTGTCCATGGTGCTGAA GGYGCTGTCCMBGGKGSKGADGGKKGGGGKAKCCCC Direction: Forward Position #: 11 Overlap #: 11 Alignment: ----------CGGGGGGGGRKGGKKGGGGKAKCCCC GGYGCTGTCCATGGTGCTGAA--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Ar Original Motif Reverse Complement GGYGCTGTCCMBGGKGSKGADGGKKGGGGKAKCCCC VRVDGGHACAVDDKGTHCTDWH VGVHGSTRYMCVDKGTBCKDDDGGKKGGGGKAKCCCC Direction: Forward Position #: 2 Overlap #: 21 Alignment: -GGYGCTGTCCMBGGKGSKGADGGKKGGGGKAKCCCC VRVDGGHACAVDDKGTHCTDWH--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 24 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar REST Reverse Complement Reverse Complement VRVDGGHACAVDDKGTHCTDWH GGYGCTGTCCATGGTGCTGAA VGVHGSTRYMCDDKGTBCTKAH Direction: Backward Position #: 1 Overlap #: 21 Alignment: VRVDGGHACAVDDKGTHCTDWH -GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif VGVHGSTRYMCDDKGTBCTKAH DGVBCABTGDWGCGKRRCSR VGVHGSTRYMCDDDGYDCTGADGCGKRRCSR Direction: Forward Position #: 12 Overlap #: 11 Alignment: VGVHGSTRYMCDDKGTBCTKAH--------- -----------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif MSGKKRCGCDTCAGDMCHHDGRKKASCDVCV VDBHMAGGTCACCCTGACCY MSGKKRCGCDTCAGDMCVHBVVDGRBCAVCCTGACCY Direction: Forward Position #: 18 Overlap #: 14 Alignment: MSGKKRCGCDTCAGDMCHHDGRKKASCDVCV------ -----------------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Reverse Complement Original Motif MGGTCAGGVTGBMCHVVBDVGYDCTGADGCGKRYCSR CCCCMAAMCAMCCMCMMMCV CCCCMRRYCAVSVHSHMCVVVBDVGYDCTGADGCGKRYCSR Direction: Forward Position #: 5 Overlap #: 16 Alignment: ----MGGTCAGGVTGBMCHVVBDVGYDCTGADGCGKRYCSR CCCCMAAMCAMCCMCMMMCV--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Reverse Complement CCCCMRRYCAVSVHSHMCVVVBDVGYDCTGADGCGKRYCSR TGRCCTKTGHCCKAB CCCCMRRYCAVSVHSHMCVVVBDDGHHCTKTDGCSKRBCSR Direction: Forward Position #: 24 Overlap #: 15 Alignment: CCCCMRRYCAVSVHSHMCVVVBDVGYDCTGADGCGKRYCSR -----------------------TGRCCTKTGHCCKAB--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Original Motif MSGBKRSGCHAYAGDHCDHBVVVGRDSDVSVTGKMKYGGGG VHRGGTCABDBTGMCCTB MSGBKRSGCHAYAGDHCDHBVVVGRDVDRGGTSAVBBKGRVCTB Direction: Forward Position #: 27 Overlap #: 15 Alignment: MSGBKRSGCHAYAGDHCDHBVVVGRDSDVSVTGKMKYGGGG--- --------------------------VHRGGTCABDBTGMCCTB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Reverse Complement Reverse Complement BAGVMCYVBVTSACCMDVHMCVVVBDDGHHCTKTDGCSKRBCSR TGMYCTTTGBCCK BAGVMCYVBVTSACCMDVHMCVVVBDTGVYCTKTGBCCKRBCSR Direction: Forward Position #: 27 Overlap #: 13 Alignment: BAGVMCYVBVTSACCMDVHMCVVVBDDGHHCTKTDGCSKRBCSR --------------------------TGMYCTTTGBCCK----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Reverse Complement Reverse Complement MSGBKRGGBCARAGKBCAHBVVVGRDVDRGGTSAVBBKGRVCTB AAAAAAACAAARRA MSRVWARRHCAAARDWCAHBVVVGRDVDRGGTSAVBBKGRVCTB Direction: Forward Position #: 3 Overlap #: 14 Alignment: MSGBKRGGBCARAGKBCAHBVVVGRDVDRGGTSAVBBKGRVCTB --AAAAAAACAAARRA---------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Reverse Complement MSRVWARRHCAAARDWCAHBVVVGRDVDRGGTSAVBBKGRVCTB CKGGDTBDMMCTGG MSRVWARRHCAAARDWCAHBVVVGRDCDGGDTBDVHCKGGVCTB Direction: Forward Position #: 27 Overlap #: 14 Alignment: MSRVWARRHCAAARDWCAHBVVVGRDVDRGGTSAVBBKGRVCTB --------------------------CKGGDTBDMMCTGG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 9 Original Motif Original Motif MSRVWARRHCAAARDWCAHBVVVGRDCDGGDTBDVHCKGGVCTB CACACAVRCACACA CACACAVRVACAMARDWCAHBVVVGRDCDGGDTBDVHCKGGVCTB Direction: Forward Position #: 2 Overlap #: 13 Alignment: -MSRVWARRHCAAARDWCAHBVVVGRDCDGGDTBDVHCKGGVCTB CACACAVRCACACA------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 25 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Arnt Esrrb Original Motif Original Motif CACGTG CACGTG CACGTG Direction: Forward Position #: 1 Overlap #: 6 Alignment: CACGTG CACGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Reverse Complement Reverse Complement CACGTG ACCACGTGSTM ACCACGTGSTM Direction: Forward Position #: 3 Overlap #: 6 Alignment: --CACGTG--- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Reverse Complement ACCACGTGSTM DCCACGTGCV DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: ACCACGTGSTM DCCACGTGCV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Mycn Original Motif Reverse Complement DCCACGTGSDM GCCACGTGSD DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: DCCACGTGSDM GCCACGTGSD- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Reverse Complement Original Motif RHSCACGTGGH VBACGTGV VBRCRYGYGGH Direction: Forward Position #: 1 Overlap #: 8 Alignment: RHSCACGTGGH VBACGTGV--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ArntAhr Reverse Complement Reverse Complement DCCMCMMGKBV CACGCM CMCGCMMGKBV Direction: Forward Position #: 1 Overlap #: 6 Alignment: DCCMCMMGKBV CACGCM----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZEB1 Combined Motif Reverse Complement Reverse Complement VBRCRYGCGYG HAGGTG VHASGTGCGYG Direction: Forward Position #: 2 Overlap #: 6 Alignment: VBRCRYGCGYG -HAGGTG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Original Motif VHASGTGCGYG HGCGTGGGCGK HGCRBGKGCGBG Direction: Forward Position #: 2 Overlap #: 10 Alignment: -VHASGTGCGYG HGCGTGGGCGK- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Original Motif CVCGCYCVMGCH BAACGTCCGC BHACGYCCGCGCH Direction: Forward Position #: 2 Overlap #: 9 Alignment: -CVCGCYCVMGCH BAACGTCCGC--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif HGCGCGGKCGTHV GGGGCCCAAGGGGG GGGGCSCRMGGGSGTHV Direction: Forward Position #: 5 Overlap #: 10 Alignment: ----HGCGCGGKCGTHV GGGGCCCAAGGGGG--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 26 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ArntAhr Egr1 Original Motif Original Motif YGCGTG HGCGTGGGCGK YGCGTGGGCGK Direction: Forward Position #: 1 Overlap #: 6 Alignment: YGCGTG----- HGCGTGGGCGK ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Original Motif Original Motif YGCGTGGGCGK VBACGTGV VBRCGTGGGCGK Direction: Forward Position #: 2 Overlap #: 7 Alignment: -YGCGTGGGCGK VBACGTGV---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 11 Original Motif Reverse Complement VBRCGTGGGCGK TGTGTGTGTGTKTG TGTGYGTGKGYGTG Direction: Forward Position #: 2 Overlap #: 12 Alignment: -VBRCGTGGGCGK- TGTGTGTGTGTKTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Esrrb Reverse Complement Reverse Complement CACMCRCACMCACA CACGTG CACGYRCACMCACA Direction: Forward Position #: 1 Overlap #: 6 Alignment: CACMCRCACMCACA CACGTG-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Arnt Original Motif Reverse Complement CACGYRCACMCACA CACGTG CACGTGCACMCACA Direction: Forward Position #: 1 Overlap #: 6 Alignment: CACGYRCACMCACA CACGTG-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 9 Original Motif Original Motif CACGTGCACMCACA CACACAVRCACACA CACRYRCACACACA Direction: Forward Position #: 1 Overlap #: 14 Alignment: CACGTGCACMCACA CACACAVRCACACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Original Motif Reverse Complement CACRYRCACACACA ACCACGTGSTM ACCACGTGSWCACACA Direction: Forward Position #: 3 Overlap #: 9 Alignment: --CACRYRCACACACA ACCACGTGSTM----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Mycn Original Motif Reverse Complement ACCACGTGSWCACACA GCCACGTGSD VCCACGTGSDCACACA Direction: Forward Position #: 1 Overlap #: 10 Alignment: ACCACGTGSWCACACA GCCACGTGSD------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Reverse Complement VCCACGTGSDCACACA DCCACGTGCV DCCACGTGSDCACACA Direction: Forward Position #: 1 Overlap #: 10 Alignment: VCCACGTGSDCACACA DCCACGTGCV------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Original Motif DCCACGTGSDCACACA CCCCMAAMCAMCCMCMMMCV CCVCCAMVYRCCCMCACACV Direction: Forward Position #: 3 Overlap #: 16 Alignment: --DCCACGTGSDCACACA-- CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 27 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- E2F1 PLAG1 Original Motif Reverse Complement TTTSGCGC CCCCCTTGGGCCCC CYYYSKYGSGCCCC Direction: Forward Position #: 2 Overlap #: 8 Alignment: -TTTSGCGC----- CCCCCTTGGGCCCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Original Motif GGGGCSCKYSKKMG BTRGGDCARAGGKCA BGRGGSSMRVGGKMR Direction: Forward Position #: 2 Overlap #: 14 Alignment: -GGGGCSCKYSKKMG BTRGGDCARAGGKCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Reverse Complement Reverse Complement MRRCCBMYSSCCMCB TGMYCTTTGBCCK HGRYCTHTGBCCBCB Direction: Forward Position #: 1 Overlap #: 13 Alignment: MRRCCBMYSSCCMCB TGMYCTTTGBCCK-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Original Motif BGBGGBCAHAGKKCH AAAGGTCAAAGGTCAAC VRRGGTCAAAGGTCAAC Direction: Forward Position #: 1 Overlap #: 15 Alignment: BGBGGBCAHAGKKCH-- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Original Motif GTTGACCTTTGACCKMB TGAMCTTTGMMCYT TGAMCKTTGACCTTTGACCKMB Direction: Forward Position #: 6 Overlap #: 9 Alignment: -----GTTGACCTTTGACCKMB TGAMCTTTGMMCYT-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Reverse Complement Original Motif VRRGGTCAAAGGTCAARGRTCA GSMMCCYARGGKKKC GSMMCCHARGGKBVMAGGTCAARGRTCA Direction: Forward Position #: 7 Overlap #: 9 Alignment: ------VRRGGTCAAAGGTCAARGRTCA GSMMCCYARGGKKKC------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Reverse Complement GSMMCCHARGGKBVMAGGTCAARGRTCA YCGCCCACGCH YCGCCMMCBMDGGKBVMAGGTCAARGRTCA Direction: Forward Position #: 3 Overlap #: 9 Alignment: --GSMMCCHARGGKBVMAGGTCAARGRTCA YCGCCCACGCH------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 10 Combined Motif Original Motif Reverse Complement YCGCCMMCBMDGGKBVMAGGTCAARGRTCA AAAAAAACAAARRA YCGCCMMCBMDGGKVAAARRHCAAAGRWCA Direction: Forward Position #: 15 Overlap #: 14 Alignment: YCGCCMMCBMDGGKBVMAGGTCAARGRTCA --------------AAAAAAACAAARRA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Original Motif YCGCCMMCBMDGGKVAAARRHCAAAGRWCA CCCCMAAMCAMCCMCMMMCV CCCCMAAMCAMCCMCMHCSCCMMCBMDGGKVAAARRHCAAAGRWCA Direction: Forward Position #: 17 Overlap #: 4 Alignment: ----------------YCGCCMMCBMDGGKVAAARRHCAAAGRWCA CCCCMAAMCAMCCMCMMMCV-------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 1 Combined Motif Reverse Complement Reverse Complement TGWMCTTTGHKMTTTBRCCDRBGRRGGSGDRGRGGRTGRTTYGGGG MTTCCK TGWMCHTTSCKMTTTBRCCDRBGRRGGSGDRGRGGRTGRTTYGGGG Direction: Forward Position #: 6 Overlap #: 6 Alignment: TGWMCTTTGHKMTTTBRCCDRBGRRGGSGDRGRGGRTGRTTYGGGG -----MTTCCK----------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 28 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Egr1 RREB1 Original Motif Reverse Complement HGCGTGGGCGK BGRRRGRGGRTGRTTYGGGG BGRRRGRDGSKKGKKYGGGG Direction: Backward Position #: 3 Overlap #: 11 Alignment: -------HGCGTGGGCGK-- BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 11 Reverse Complement Original Motif CCCCKYYCYYSCHMCMMMCB CAYACACACACACA CAYACACACMCMCDYYCYYSCHMCMMMCB Direction: Forward Position #: 10 Overlap #: 5 Alignment: ---------CCCCKYYCYYSCHMCMMMCB CAYACACACACACA--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 9 Combined Motif Reverse Complement Reverse Complement BGRRRGRDGSKKGKKDGYGYGTGTGTKTG TGTGTGKVTGTGTG BGRRRGRTGBGTGKBTGTGTGTGTGTKTG Direction: Forward Position #: 8 Overlap #: 14 Alignment: BGRRRGRDGSKKGKKDGYGYGTGTGTKTG -------TGTGTGKVTGTGTG-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Original Motif BGRRRGRTGBGTGKBTGTGTGTGTGTKTG GSMMCCYARGGKKKC GSMMCCBARGGGKGHGTGKBTGTGTGTGTGTKTG Direction: Forward Position #: 6 Overlap #: 10 Alignment: -----BGRRRGRTGBGTGKBTGTGTGTGTGTKTG GSMMCCYARGGKKKC------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Reverse Complement GSMMCCBARGGGKGHGTGKBTGTGTGTGTGTKTG VAGGCCBBGGCVBB GSMMCCBVAGGSYBBGKSBBBGTGTGTGTGTKTG Direction: Forward Position #: 8 Overlap #: 14 Alignment: GSMMCCBARGGGKGHGTGKBTGTGTGTGTGTKTG -------VAGGCCBBGGCVBB------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement CAYACACACACACVBBSYCBBKSCCTBBGGYRSC MSGKKRCGCWDCABTGBBCD CAYACACACMCRBDVCGCHDCVBYSTBVKGYRSC Direction: Forward Position #: 10 Overlap #: 20 Alignment: CAYACACACACACVBBSYCBBKSCCTBBGGYRSC ---------MSGKKRCGCWDCABTGBBCD----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Reverse Complement GSMMCYVVASKBVGDDGCGBHBKGYGTGTGTKTG MGCCCCCTGMCA MGSCCCCDDMCRBVGDDGCGBHBKGYGTGTGTKTG Direction: Forward Position #: 2 Overlap #: 11 Alignment: -GSMMCYVVASKBVGDDGCGBHBKGYGTGTGTKTG MGCCCCCTGMCA----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Reverse Complement Reverse Complement CAYACACACMCRBDVCGCHDCVBKGYHDGGGGSCR TGMYCTTTGBCCK CAYACACACMCRBGVYSYTTSBBBKYHDGGGGSCR Direction: Forward Position #: 13 Overlap #: 13 Alignment: CAYACACACMCRBDVCGCHDCVBKGYHDGGGGSCR ------------TGMYCTTTGBCCK---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Original Motif Reverse Complement CAYACACACMCRBGVYSYTTSBBBKYHDGGGGSCR GGGGGYGGGG CAYACACACMCRBGVYSYTTSBBBGKBGGGGGGSR Direction: Forward Position #: 25 Overlap #: 10 Alignment: CAYACACACMCRBGVYSYTTSBBBKYHDGGGGSCR ------------------------GGGGGYGGGG- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 Combined Motif Reverse Complement Reverse Complement MSCCCCCCBYCBBBSAAMSKBCVKGYGTGTGTKTG GCCYCMCCCD MSCCCCSCCYCVCCCAAMSKBCVKGYGTGTGTKTG Direction: Forward Position #: 7 Overlap #: 10 Alignment: MSCCCCCCBYCBBBSAAMSKBCVKGYGTGTGTKTG ------GCCYCMCCCD------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 29 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Pax5 Reverse Complement Reverse Complement MGGTCAGGGTGACCTRDBHV MSGKKRCGCWDCABTGBBCD MGGTBAVGCTKVMCTGBBMD Direction: Backward Position #: 1 Overlap #: 20 Alignment: MGGTCAGGGTGACCTRDBHV MSGKKRCGCWDCABTGBBCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement MGGTBAVGCTKVMCTGBBMD VRVDGGHACAVDDKGTHCTDWH MGGTBAVGSDBVVSTRCHVDDKGTHCTDWH Direction: Forward Position #: 9 Overlap #: 12 Alignment: MGGTBAVGCTKVMCTGBBMD---------- --------VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Reverse Complement Original Motif HWDAGHACRHHVHGKASVBBDSCVTBACCY CCCCMAAMCAMCCMCMMMCV CCHCARAMCAMCVHSHMCSVBDSCVTBACCY Direction: Forward Position #: 2 Overlap #: 19 Alignment: -HWDAGHACRHHVHGKASVBBDSCVTBACCY CCCCMAAMCAMCCMCMMMCV----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Original Motif MGGTBAVGSDBVSGYHSDVGRTGYTMTGDGG VHRGGTCABDBTGMCCTB MGGTBAVGSDBVSGYHSDVDRKGTCABDDKGMCCTB Direction: Forward Position #: 19 Overlap #: 13 Alignment: MGGTBAVGSDBVSGYHSDVGRTGYTMTGDGG----- ------------------VHRGGTCABDBTGMCCTB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Reverse Complement Original Motif BAGGYCRHHVTGACRMHVHSHMCSVBDSCVTBACCY RGKTCABVVRGAGGTCA BAGGYCRHHVTGACRMHVHSHRGBTCABVVDGASSTCA Direction: Forward Position #: 22 Overlap #: 15 Alignment: BAGGYCRHHVTGACRMHVHSHMCSVBDSCVTBACCY-- ---------------------RGKTCABVVRGAGGTCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif BAGGYCRHHVTGACRMHVHSHRGBTCABVVDGASSTCA TTCAGCACCATGGACAGCKCC TBMRGBMCCHHKGACAGCDVCHRGBTCABVVDGASSTCA Direction: Forward Position #: 2 Overlap #: 20 Alignment: -BAGGYCRHHVTGACRMHVHSHRGBTCABVVDGASSTCA TTCAGCACCATGGACAGCKCC------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Original Motif Original Motif TBMRGBMCCHHKGACAGCDVCHRGBTCABVVDGASSTCA GGGTCAWBGRGTTCA GGGTCAHBVRGTWCMHHKGACAGCDVCHRGBTCABVVDGASSTCA Direction: Forward Position #: 7 Overlap #: 9 Alignment: ------TBMRGBMCCHHKGACAGCDVCHRGBTCABVVDGASSTCA GGGTCAWBGRGTTCA------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Original Motif GGGTCAHBVRGTWCMHHKGACAGCDVCHRGBTCABVVDGASSTCA BTRGGDCARAGGKCA GGGTCAHBVRGTWCMHHKGACAGCDVBDRGBBMAVGGKSASSTCA Direction: Forward Position #: 26 Overlap #: 15 Alignment: GGGTCAHBVRGTWCMHHKGACAGCDVCHRGBTCABVVDGASSTCA -------------------------BTRGGDCARAGGKCA----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif GGGTCAHBVRGTWCMHHKGACAGCDVBDRGBBMAVGGKSASSTCA BBVGCCBVGGCCTV GGGTCAHBVRGTWCMHHKGACAGCDVBDRGBBVRVSGDGRCCTSA Direction: Forward Position #: 31 Overlap #: 14 Alignment: GGGTCAHBVRGTWCMHHKGACAGCDVBDRGBBMAVGGKSASSTCA ------------------------------BBVGCCBVGGCCTV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Original Motif Reverse Complement GGGTCAHBVRGTWCMHHKGACAGCDVBDRGBBVRVSGDGRCCTSA GYRYCCMTKGGYRSC GGGTCAHBVRGDYCCMWKGRCRSCDVBDRGBBVRVSGDGRCCTSA Direction: Forward Position #: 10 Overlap #: 15 Alignment: GGGTCAHBVRGTWCMHHKGACAGCDVBDRGBBVRVSGDGRCCTSA ---------GYRYCCMTKGGYRSC--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 30 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Ar Reverse Complement Original Motif BAGGYCABHBTGACCKHV HWDAGHACRHHVTGTHCCHVMV HWHAGDWCAHHVTGWCCBHVMV Direction: Forward Position #: 3 Overlap #: 18 Alignment: --BAGGYCABHBTGACCKHV-- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif VRVHBGGWCAVDDTGWHCTHWH DGVBCABTGDWGCGKRRCSR VRVHBGGWCAVGDKSWVYKDWGCGKRRCSR Direction: Forward Position #: 11 Overlap #: 12 Alignment: VRVHBGGWCAVDDTGWHCTHWH-------- ----------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement VRVHBGGWCAVGDKSWVYKDWGCGKRRCSR BGRRRGRGGRTGRTTYGGGG VRVHBGGWCAVGDKSWVYGRDDSGKGRYGRTTYGGGG Direction: Forward Position #: 18 Overlap #: 13 Alignment: VRVHBGGWCAVGDKSWVYKDWGCGKRRCSR------- -----------------BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Reverse Complement VRVHBGGWCAVGDKSWVYGRDDSGKGRYGRTTYGGGG GGYGCTGTCCATGGTGCTGAA GRHDCKGTCMVDGGTDCTGADDSGKGRYGRTTYGGGG Direction: Forward Position #: 1 Overlap #: 21 Alignment: VRVHBGGWCAVGDKSWVYGRDDSGKGRYGRTTYGGGG GGYGCTGTCCATGGTGCTGAA---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif CCCCMAAMCMMCYCSHDTCAGHACCDBRGACRGHDMC VDBHMAGGTCACCCTGACCY CCCCMAAMCMMCYCSHDTCAGHVBBVHRGRYVRVBCYGACCY Direction: Forward Position #: 23 Overlap #: 15 Alignment: CCCCMAAMCMMCYCSHDTCAGHACCDBRGACRGHDMC----- ----------------------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Reverse Complement Original Motif MGGTCMGBVKVKMCKDVBBBDCTGADDSGKGRYGRTTYGGGG RGKTCABVVRGAGGTCA MGGTCMGBVKVKMCKRGKTBABBGAVRGGKSAYGRTTYGGGG Direction: Forward Position #: 16 Overlap #: 17 Alignment: MGGTCMGBVKVKMCKDVBBBDCTGADDSGKGRYGRTTYGGGG ---------------RGKTCABVVRGAGGTCA---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif CCCCMAAMCMTSRCCKVTCVBTBAYCMRGRYVRVBCYGACCY BTRGGDCARAGGKCA CCCCMAAMCMTSRCCKVTCVBTBABBVRGDCARAGVTSACCY Direction: Forward Position #: 25 Overlap #: 15 Alignment: CCCCMAAMCMTSRCCKVTCVBTBAYCMRGRYVRVBCYGACCY ------------------------BTRGGDCARAGGKCA--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif CCCCMAAMCMTSRCCKVTCVBTBABBVRGDCARAGVTSACCY BBVGCCBVGGCCTV CCCCMAAMCMTSRCCKVTCVBTBABBVRGDBVVVSCBVRSCCTV Direction: Forward Position #: 31 Overlap #: 12 Alignment: CCCCMAAMCMTSRCCKVTCVBTBABBVRGDCARAGVTSACCY-- ------------------------------BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Original Motif Original Motif CCCCMAAMCMTSRCCKVTCVBTBABBVRGDBVVVSCBVRSCCTV TGAMCTTTGMMCYT CCCCMAAMCMTGAMCTHTSVVYBDBBVRGDBVVVSCBVRSCCTV Direction: Forward Position #: 11 Overlap #: 14 Alignment: CCCCMAAMCMTSRCCKVTCVBTBABBVRGDBVVVSCBVRSCCTV ----------TGAMCTTTGMMCYT-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Original Motif Original Motif CCCCMAAMCMTGAMCTHTSVVYBDBBVRGDBVVVSCBVRSCCTV CCAGYYHVADCCRG CCCCMAAMCMTGAMCTHTSVVYBDCCRGBBBVRDCCDGRSCCTV Direction: Forward Position #: 25 Overlap #: 14 Alignment: CCCCMAAMCMTGAMCTHTSVVYBDBBVRGDBVVVSCBVRSCCTV ------------------------CCAGYYHVADCCRG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 31 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Esrrb Arnt Original Motif Original Motif CACGTG CACGTG CACGTG Direction: Forward Position #: 1 Overlap #: 6 Alignment: CACGTG CACGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Reverse Complement Reverse Complement CACGTG ACCACGTGSTM ACCACGTGSTM Direction: Forward Position #: 3 Overlap #: 6 Alignment: --CACGTG--- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Reverse Complement ACCACGTGSTM DCCACGTGCV DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: ACCACGTGSTM DCCACGTGCV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Mycn Original Motif Reverse Complement DCCACGTGSDM GCCACGTGSD DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: DCCACGTGSDM GCCACGTGSD- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HIF1AARNT Reverse Complement Original Motif RHSCACGTGGH VBACGTGV VBRCRYGYGGH Direction: Forward Position #: 1 Overlap #: 8 Alignment: RHSCACGTGGH VBACGTGV--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ArntAhr Reverse Complement Reverse Complement DCCMCMMGKBV CACGCM CMCGCMMGKBV Direction: Forward Position #: 1 Overlap #: 6 Alignment: DCCMCMMGKBV CACGCM----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZEB1 Combined Motif Reverse Complement Reverse Complement VBRCRYGCGYG HAGGTG VHASGTGCGYG Direction: Forward Position #: 2 Overlap #: 6 Alignment: VBRCRYGCGYG -HAGGTG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Original Motif VHASGTGCGYG HGCGTGGGCGK HGCRBGKGCGBG Direction: Forward Position #: 2 Overlap #: 10 Alignment: -VHASGTGCGYG HGCGTGGGCGK- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Original Motif CVCGCYCVMGCH BAACGTCCGC BHACGYCCGCGCH Direction: Forward Position #: 2 Overlap #: 9 Alignment: -CVCGCYCVMGCH BAACGTCCGC--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif HGCGCGGKCGTHV GGGGCCCAAGGGGG GGGGCSCRMGGGSGTHV Direction: Forward Position #: 5 Overlap #: 10 Alignment: ----HGCGCGGKCGTHV GGGGCCCAAGGGGG--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 32 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- EWSR1-FLI1 NR1H2RXRA Original Motif Original Motif GGAAGGAAGGAAGGAAGG AAAGGTCAAAGGTCAAC GGAAGGAARGRWSRAAGGTCAAC Direction: Backward Position #: 6 Overlap #: 12 Alignment: GGAAGGAAGGAAGGAAGG----- ------AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 10 Original Motif Reverse Complement GGAAGGAARGRWSRAAGGTCAAC AAAAAAACAAARRA AARRAARGAAAGRWSRAAGGTCAAC Direction: Forward Position #: 3 Overlap #: 12 Alignment: --GGAAGGAARGRWSRAAGGTCAAC AAAAAAACAAARRA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Reverse Complement AARRAARGAAAGRWSRAAGGTCAAC BGRRRGRGGRTGRTTYGGGG BGRRRGRGGRTGRTTYRRGRAARGAAAGRWSRAAGGTCAAC Direction: Forward Position #: 17 Overlap #: 4 Alignment: ----------------AARRAARGAAAGRWSRAAGGTCAAC BGRRRGRGGRTGRTTYGGGG--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Original Motif Reverse Complement BGRRRGRGGRTGRTTYRRGRAARGAAAGRWSRAAGGTCAAC GGGGGYGGGG BGRRRGRGGGKGGYKKGGGRAARGAAAGRWSRAAGGTCAAC Direction: Forward Position #: 9 Overlap #: 10 Alignment: BGRRRGRGGRTGRTTYRRGRAARGAAAGRWSRAAGGTCAAC --------GGGGGYGGGG----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Reverse Complement GTTGACCTTKSWKCTTTCMTTMCCCYRMCCRCCCMCMMMCB GCGGACGTTV GYKGACSTTDSWKCTTTCMTTMCCCYRMCCRCCCMCMMMCB Direction: Forward Position #: 1 Overlap #: 10 Alignment: GTTGACCTTKSWKCTTTCMTTMCCCYRMCCRCCCMCMMMCB GCGGACGTTV------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 7 Combined Motif Reverse Complement Reverse Complement BGRRRGRGGGKGGYKKGGGRAARGAAAGRWSHAASGTCRKC GGGGMGGG BGRRRGRGGGKGGYKKGGGGARGGAAAGRWSHAASGTCRKC Direction: Forward Position #: 17 Overlap #: 8 Alignment: BGRRRGRGGGKGGYKKGGGRAARGAAAGRWSHAASGTCRKC ----------------GGGGMGGG----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Reverse Complement GYKGACSTTDSWKCTTTCCMTCCCCYRMCCRCCCMCMMMCB MGGTCAGGGTGACCTRDBHV GYKGACSTTDSWKCTTTCCMKSYCMBRVYSACCHVVVHMCB Direction: Forward Position #: 20 Overlap #: 20 Alignment: GYKGACSTTDSWKCTTTCCMTCCCCYRMCCRCCCMCMMMCB -------------------MGGTCAGGGTGACCTRDBHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 Combined Motif Original Motif Reverse Complement GYKGACSTTDSWKCTTTCCMKSYCMBRVYSACCHVVVHMCB GCCYCMCCCD GYKGACSTTDSWKCTTKCCHCVCCCDRVYSACCHVVVHMCB Direction: Forward Position #: 17 Overlap #: 10 Alignment: GYKGACSTTDSWKCTTTCCMKSYCMBRVYSACCHVVVHMCB ----------------GCCYCMCCCD--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 3 Original Motif Original Motif GYKGACSTTDSWKCTTKCCHCVCCCDRVYSACCHVVVHMCB AGSCWGG AGSCTGRCSTTDSWKCTTKCCHCVCCCDRVYSACCHVVVHMCB Direction: Forward Position #: 3 Overlap #: 5 Alignment: --GYKGACSTTDSWKCTTKCCHCVCCCDRVYSACCHVVVHMCB AGSCWGG------------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RORA_1 Reverse Complement Reverse Complement BGRDVVBDGGTSMBMHGGGVGDGGRAAGRWSHAASGMCAGSCT TGACCTDVWT TGACCTDVDDVBDGGTSMBMHGGGVGDGGRAAGRWSHAASGMCAGSCT Direction: Forward Position #: 6 Overlap #: 5 Alignment: -----BGRDVVBDGGTSMBMHGGGVGDGGRAAGRWSHAASGMCAGSCT TGACCTDVWT-------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 33 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HIF1AARNT Mycn Original Motif Reverse Complement VBACGTGV GCCACGTGSD GSCACGTGSD Direction: Forward Position #: 2 Overlap #: 8 Alignment: -VBACGTGV- GCCACGTGSD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Reverse Complement GSCACGTGSD DCCACGTGCV GCCACGTGSV Direction: Forward Position #: 1 Overlap #: 10 Alignment: GSCACGTGSD DCCACGTGCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Original Motif Reverse Complement GCCACGTGSV ACCACGTGSTM DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: GCCACGTGSV- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Reverse Complement Reverse Complement RDSCACGTGGD GCGGACGTTV GCGSACGTKGD Direction: Forward Position #: 1 Overlap #: 10 Alignment: RDSCACGTGGD GCGGACGTTV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Ar Reverse Complement Reverse Complement DCYACGTSCGC VRVDGGHACAVDDKGTHCTDWH VVHASGTVCVVDDKGTHCTDWH Direction: Forward Position #: 1 Overlap #: 11 Alignment: DCYACGTSCGC----------- VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Reverse Complement HWDAGHACRHHVBGBACSTDVV MSGKKRCGCWDCABTGBBCD HWDAGHACRHMSGGKACGYDDCABTGBBCD Direction: Forward Position #: 11 Overlap #: 12 Alignment: HWDAGHACRHHVBGBACSTDVV-------- ----------MSGKKRCGCWDCABTGBBCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Original Motif Original Motif HWDAGHACRHMSGGKACGYDDCABTGBBCD CCCCMAAMCAMCCMCMMMCV CCCCMAAMCAMSMMCVHMSVGKACGYDDCABTGBBCD Direction: Forward Position #: 8 Overlap #: 13 Alignment: -------HWDAGHACRHMSGGKACGYDDCABTGBBCD CCCCMAAMCAMCCMCMMMCV----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_5-13 Combined Motif Reverse Complement Original Motif HGVBCABTGDDKCGTRCVSRDBGYRSYTGRTTYGGGG BKAGGGGDAD HGVBCABTGDDKCGTRBDAGGGGBRVYTGRTTYGGGG Direction: Forward Position #: 17 Overlap #: 10 Alignment: HGVBCABTGDDKCGTRCVSRDBGYRSYTGRTTYGGGG ----------------BKAGGGGDAD----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Original Motif CCCCMAAMCAMVKVCCCCTHBKACGYDDCABTGBBCD VHRGGTCABDBTGMCCTB CCCCMAAMCAMVKVCCCCTHBKVMRBGTCABDDTDMHCTB Direction: Forward Position #: 23 Overlap #: 15 Alignment: CCCCMAAMCAMVKVCCCCTHBKACGYDDCABTGBBCD--- ----------------------VHRGGTCABDBTGMCCTB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Original Motif CCCCMAAMCAMVKVCCCCTHBKVMRBGTCABDDTDMHCTB RGKTCABVVRGAGGTCA CCCCMAAMCAMVKRSBYCWBVBVVRGGTCABDDTDMHCTB Direction: Forward Position #: 14 Overlap #: 17 Alignment: CCCCMAAMCAMVKVCCCCTHBKVMRBGTCABDDTDMHCTB -------------RGKTCABVVRGAGGTCA---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 34 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A PPARGRXRA Original Motif Original Motif RGGBCAAAGKYCA BTRGGDCARAGGKCA BTRGGBCAAAGGTCA Direction: Forward Position #: 3 Overlap #: 13 Alignment: --RGGBCAAAGKYCA BTRGGDCARAGGKCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Original Motif TGACCTTTGBCCKAB TGAMCTTTGMMCYT TGACCTTTGVMCBHB Direction: Forward Position #: 1 Overlap #: 14 Alignment: TGACCTTTGBCCKAB TGAMCTTTGMMCYT- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Original Motif BHVGRVCAAAGGTCA AAAGGTCAAAGGTCAAC VAAGGTCAAAGGTCAAC Direction: Forward Position #: 1 Overlap #: 15 Alignment: BHVGRVCAAAGGTCA-- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRRAR_DR5 Original Motif Original Motif VAAGGTCAAAGGTCAAC RGKTCABVVRGAGGTCA RGDTMRBBCARAGGTCAAC Direction: Forward Position #: 3 Overlap #: 15 Alignment: --VAAGGTCAAAGGTCAAC RGKTCABVVRGAGGTCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Pax5 Original Motif Original Motif RGDTMRBBCARAGGTCAAC DGVBCABTGDWGCGKRRCSR DGVBCABTGDWGCGKRGVBVRBBCARAGGTCAAC Direction: Forward Position #: 16 Overlap #: 5 Alignment: ---------------RGDTMRBBCARAGGTCAAC DGVBCABTGDWGCGKRRCSR-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Original Motif GTTGACCTKTGVBKBVVCKRCGCWDCABTGBBCD VHRGGTCABDBTGMCCTB GTTGACCTDKGDCWBDBYGACSYDDCABTGBBCD Direction: Forward Position #: 7 Overlap #: 18 Alignment: GTTGACCTKTGVBKBVVCKRCGCWDCABTGBBCD ------VHRGGTCABDBTGMCCTB---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Original Motif GTTGACCTDKGDCWBDBYGACSYDDCABTGBBCD HWDAGHACRHHVTGTHCCHVMV GTTGACCTDKGDCWBDBYDDMVSHWCABHVYGHDCCHVMV Direction: Forward Position #: 19 Overlap #: 16 Alignment: GTTGACCTDKGDCWBDBYGACSYDDCABTGBBCD------ ------------------HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif GTTGACCTDKGDCWBDBYDDMVSHWCABHVYGHDCCHVMV VDBHMAGGTCACCCTGACCY GTTGACCTDKGDCWBDBYDDMVSHDCVBHRBGTHMCHVTGACCY Direction: Forward Position #: 25 Overlap #: 16 Alignment: GTTGACCTDKGDCWBDBYDDMVSHWCABHVYGHDCCHVMV---- ------------------------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif MGGTCAVDGRDACBKDBBGDHSBRDHMBHBWGDCYHAGGTCAAC GGGGCCCAAGGGGG GRGGYCMDVGGGRSBKDBBGDHSBRDHMBHBWGDCYHAGGTCAAC Direction: Forward Position #: 2 Overlap #: 13 Alignment: -MGGTCAVDGRDACBKDBBGDHSBRDHMBHBWGDCYHAGGTCAAC GGGGCCCAAGGGGG------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Reverse Complement Original Motif GTTGACCTDKGDCWBDBYDDMVSHDCVBHRBSMCCCBDRGKCCMC TTCAGCACCATGGACAGCKCC GTTGACCTDKKTCAGBACCAHGGAVAGCDVBSMCCCBDRGKCCMC Direction: Forward Position #: 11 Overlap #: 21 Alignment: GTTGACCTDKGDCWBDBYDDMVSHDCVBHRBSMCCCBDRGKCCMC ----------TTCAGCACCATGGACAGCKCC-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 35 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 PPARGRXRA Original Motif Original Motif TGYCAGGGGGCR BTRGGDCARAGGKCA BTRKGBCAGRGGKCA Direction: Forward Position #: 4 Overlap #: 12 Alignment: ---TGYCAGGGGGCR BTRGGDCARAGGKCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Original Motif Reverse Complement BTRKGBCAGRGGKCA BGRRRGRGGRTGRTTYGGGG BBRDGGVRGRKGGYWYGGGG Direction: Forward Position #: 1 Overlap #: 15 Alignment: BTRKGBCAGRGGKCA----- BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Original Motif BBRDGGVRGRKGGYWYGGGG GSMMCCYARGGKKKC GSVVCSBVRGGKGKCWYGGGG Direction: Forward Position #: 2 Overlap #: 14 Alignment: -BBRDGGVRGRKGGYWYGGGG GSMMCCYARGGKKKC------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Reverse Complement Reverse Complement CCCCMWGYCRCCKBVSGBVSC TGMYCTTTGBCCK CCCCMDGVYVYYTKVBSKVSC Direction: Forward Position #: 6 Overlap #: 13 Alignment: CCCCMWGYCRCCKBVSGBVSC -----TGMYCTTTGBCCK--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif GSVRSBVYAKMVKVCDYGGGG VDBHMAGGTCACCCTGACCY GSVVBBVHRGHCRVCHTGRSVY Direction: Forward Position #: 3 Overlap #: 19 Alignment: GSVRSBVYAKMVKVCDYGGGG- --VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif MVSKCADGVKGHCMHVBBVVSC DGVBCABTGDWGCGKRRCSR MVSKCADGVKVRHVHVBBVVDSCGKRRCSR Direction: Forward Position #: 11 Overlap #: 12 Alignment: MVSKCADGVKGHCMHVBBVVSC-------- ----------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Original Motif MSGKKRCGSHBVVBBDVDMVRVCHTGRSVY BBVGCCBVGGCCTV MSGKKRCGSHBVVBBDVDVVVVCCTGGGCCTV Direction: Forward Position #: 19 Overlap #: 12 Alignment: MSGKKRCGSHBVVBBDVDMVRVCHTGRSVY-- ------------------BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 36 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 RREB1 Original Motif Reverse Complement DGGGYGKGGC BGRRRGRGGRTGRTTYGGGG BGRRRGRGGRTGGKTKGGGV Direction: Backward Position #: 1 Overlap #: 10 Alignment: ----------DGGGYGKGGC BGRRRGRGGRTGRTTYGGGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfx Original Motif Original Motif BGRRRGRGGRTGGKTKGGGV BBVGCCBVGGCCTV BBSGVBGRGGSYKGKTKGGGV Direction: Forward Position #: 2 Overlap #: 13 Alignment: -BGRRRGRGGRTGGKTKGGGV BBVGCCBVGGCCTV------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Original Motif Reverse Complement BBSGVBGRGGSYKGKTKGGGV GGGGGYGGGG BBSGVBGGGGBBGGGTKGGGV Direction: Forward Position #: 6 Overlap #: 10 Alignment: BBSGVBGRGGSYKGKTKGGGV -----GGGGGYGGGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 37 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MIZF MYCMAX Original Motif Reverse Complement BAACGTCCGC ACCACGTGSTM ACMACGTSCKC Direction: Forward Position #: 2 Overlap #: 10 Alignment: -BAACGTCCGC ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Reverse Complement Reverse Complement GYGSACGTRGT BAGGYCABHBTGACCKHV VMGGACRTVBTGACCKHV Direction: Forward Position #: 1 Overlap #: 11 Alignment: GYGSACGTRGT------- BAGGYCABHBTGACCKHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Reverse Complement VMGGACRTVBTGACCKHV MGGTCAGGGTGACCTRDBHV VMGGWCABDBTGACCKDDBHV Direction: Forward Position #: 2 Overlap #: 17 Alignment: VMGGACRTVBTGACCKHV--- -MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Reverse Complement VDBHHRGGTCABHVTGWCCYV VRVDGGHACAVDDKGTHCTDWH VVVVHRGDWCAVBDTGTYCTHWH Direction: Forward Position #: 2 Overlap #: 20 Alignment: VDBHHRGGTCABHVTGWCCYV-- -VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Original Motif HWHAGKACAHBVTGWHCMHVVVV AAAGGTCAAAGGTCAAC AAAGGTCAAAGGTCAABVTGWHCMHVVVV Direction: Forward Position #: 7 Overlap #: 11 Alignment: ------HWHAGKACAHBVTGWHCMHVVVV AAAGGTCAAAGGTCAAC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif AAAGGTCAAAGGTCAABVTGWHCMHVVVV TTCAGCACCATGGACAGCKCC TWMAGSWCMAWGGWCARCDYSWHCMHVVVV Direction: Forward Position #: 2 Overlap #: 20 Alignment: -AAAGGTCAAAGGTCAABVTGWHCMHVVVV TTCAGCACCATGGACAGCKCC--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Reverse Complement TWMAGSWCMAWGGWCARCDYSWHCMHVVVV MSGKKRCGCWDCABTGBBCD TWMAGSWCMAWGGWCAVSGBBWCSCDDCVVTGBBCD Direction: Forward Position #: 17 Overlap #: 14 Alignment: TWMAGSWCMAWGGWCARCDYSWHCMHVVVV------ ----------------MSGKKRCGCWDCABTGBBCD ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Reverse Complement Reverse Complement HGVBCAVBGHDGSGWBVCSBTGWCCWTRGWSCTRWA DCCACGTGCV DCCACGTGCVVBGHDGSGWBVCSBTGWCCWTRGWSCTRWA Direction: Forward Position #: 5 Overlap #: 6 Alignment: ----HGVBCAVBGHDGSGWBVCSBTGWCCWTRGWSCTRWA DCCACGTGCV------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Egr1 Original Motif Reverse Complement DCCACGTGCVVBGHDGSGWBVCSBTGWCCWTRGWSCTRWA YCGCCCACGCH YCSCMCRCGCHVBGHDGSGWBVCSBTGWCCWTRGWSCTRWA Direction: Forward Position #: 2 Overlap #: 10 Alignment: -DCCACGTGCVVBGHDGSGWBVCSBTGWCCWTRGWSCTRWA YCGCCCACGCH------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn Combined Motif Reverse Complement Original Motif TWMAGSWCMAWGGWCAVSGBBWCSCDDCVVHGCGMGRGSGK HSCACGTGGC TWMAGSWCMAWGGHCMACGTGRCSCDDCVVHGCGMGRGSGK Direction: Forward Position #: 14 Overlap #: 10 Alignment: TWMAGSWCMAWGGWCAVSGBBWCSCDDCVVHGCGMGRGSGK -------------HSCACGTGGC------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 38 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Myc Mycn Original Motif Original Motif VGCACGTGGH HSCACGTGGC VSCACGTGGC Direction: Backward Position #: 1 Overlap #: 10 Alignment: VGCACGTGGH HSCACGTGGC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Reverse Complement Reverse Complement GCCACGTGSV ACCACGTGSTM DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: GCCACGTGSV- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Original Motif RDSCACGTGGD TGYCAGGGGGCR KGBCASGKGGHR Direction: Forward Position #: 1 Overlap #: 11 Alignment: RDSCACGTGGD- TGYCAGGGGGCR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Reverse Complement MDCCYCSTGBCR GCCYCMCCCD GCCYCHCCYRBCR Direction: Forward Position #: 2 Overlap #: 9 Alignment: -MDCCYCSTGBCR GCCYCMCCCD--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Reverse Complement GCCYCHCCYRBCR VAGGCCBBGGCVBB GCASSCCCYGSCVBB Direction: Forward Position #: 2 Overlap #: 12 Alignment: GCCYCHCCYRBCR-- -VAGGCCBBGGCVBB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif BBBGSCKGGGSSTGC GGGGCCCAAGGGGG GGGGSSCHVGGGGGTGC Direction: Forward Position #: 3 Overlap #: 12 Alignment: --BBBGSCKGGGSSTGC GGGGCCCAAGGGGG--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Original Motif GGGGSSCHVGGGGGTGC GSMMCCYARGGKKKC GGVVCCYADGGGGGHGC Direction: Forward Position #: 1 Overlap #: 15 Alignment: GGGGSSCHVGGGGGTGC GSMMCCYARGGKKKC-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Original Motif GGVVCCYADGGGGGHGC RGGBCAAAGKYCA GGVVCMHAGGGSDGHGC Direction: Forward Position #: 1 Overlap #: 13 Alignment: GGVVCCYADGGGGGHGC RGGBCAAAGKYCA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Reverse Complement GGVVCMHAGGGSDGHGC MGGTCAGGGTGACCTRDBHV MGGTCAGGGTGACCTGGVBCMHAGGGSDGHGC Direction: Forward Position #: 16 Overlap #: 5 Alignment: ---------------GGVVCMHAGGGSDGHGC MGGTCAGGGTGACCTRDBHV------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Original Motif MGGTCAGGGTGACCTGGVBCMHAGGGSDGHGC HWDAGHACRHHVTGTHCCHVMV MGGTCAGGGTGACCTGGVBHHHAGDDCRBHVYGTHCCHVMV Direction: Forward Position #: 20 Overlap #: 13 Alignment: MGGTCAGGGTGACCTGGVBCMHAGGGSDGHGC--------- -------------------HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 39 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MYCMAX RREB1 Reverse Complement Original Motif ACCACGTGSTM CCCCMAAMCAMCCMCMMMCV CCCCMMACSWSCHMCMMMCV Direction: Backward Position #: 7 Overlap #: 11 Alignment: ---ACCACGTGSTM------ CCCCMAAMCAMCCMCMMMCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Reverse Complement BGRRRGRDGSWSGTRRGGGG VRVDGGHACAVDDKGTHCTDWH BGRVDGGDRCWSGTKGKDSKDWH Direction: Forward Position #: 2 Overlap #: 19 Alignment: BGRRRGRDGSWSGTRRGGGG--- -VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Original Motif Original Motif BGRVDGGDRCWSGTKGKDSKDWH GSMMCCYARGGKKKC BGRVDGGHMCMBRDGGKKSVDWH Direction: Forward Position #: 6 Overlap #: 15 Alignment: BGRVDGGDRCWSGTKGKDSKDWH -----GSMMCCYARGGKKKC--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Original Motif BGRVDGGHMCMBRDGGKKSVDWH GGGGCCCAAGGGGG BGRVDGGGGCCCADGGGGGVDWH Direction: Forward Position #: 6 Overlap #: 14 Alignment: BGRVDGGHMCMBRDGGKKSVDWH -----GGGGCCCAAGGGGG---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- INSM1 Combined Motif Reverse Complement Reverse Complement HWDVCCCCCDTGGGCCCCHVMCB MGCCCCCTGMCA HWDVCBCCCCYDGRCMCCHVMCB Direction: Forward Position #: 5 Overlap #: 12 Alignment: HWDVCCCCCDTGGGCCCCHVMCB ----MGCCCCCTGMCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif HWDVCBCCCCYDGRCMCCHVMCB TTCAGCACCATGGACAGCKCC HTHASBMCCHYGGACASCDVCCB Direction: Forward Position #: 1 Overlap #: 21 Alignment: HWDVCBCCCCYDGRCMCCHVMCB TTCAGCACCATGGACAGCKCC-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement BGGVDGSTGTCCMDGGYBSTDAH BAGGYCABHBTGACCKHV BGGVHGSTSDCCVTGRCCBTDAH Direction: Forward Position #: 4 Overlap #: 18 Alignment: BGGVDGSTGTCCMDGGYBSTDAH ---BAGGYCABHBTGACCKHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif HTHABGGMCAVGGDSASCHVCCB VDBHMAGGTCACCCTGACCY HTHABGGMCAVDDBVMVSGBCMBCCTGACCY Direction: Forward Position #: 12 Overlap #: 12 Alignment: HTHABGGMCAVGGDSASCHVCCB-------- -----------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Reverse Complement Original Motif MGGTCAGGBYGVCSBYVVHHVTGRCCBTDAH RGKTCABVVRGAGGTCA MGGTCARGKTSABSBHSASBHBRRCCBTDAH Direction: Forward Position #: 7 Overlap #: 17 Alignment: MGGTCAGGBYGVCSBYVVHHVTGRCCBTDAH ------RGKTCABVVRGAGGTCA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif MGGTCARGKTSABSBHSASBHBRRCCBTDAH BBVGCCBVGGCCTV MGGTCARGKTSABSBHSASBBBRVCBVGGMCTV Direction: Forward Position #: 20 Overlap #: 12 Alignment: MGGTCARGKTSABSBHSASBHBRRCCBTDAH-- -------------------BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 40 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn Myc Original Motif Original Motif HSCACGTGGC VGCACGTGGH VSCACGTGGC Direction: Backward Position #: 1 Overlap #: 10 Alignment: HSCACGTGGC VGCACGTGGH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MYCMAX Reverse Complement Reverse Complement GCCACGTGSV ACCACGTGSTM DCCACGTGSDM Direction: Forward Position #: 1 Overlap #: 10 Alignment: GCCACGTGSV- ACCACGTGSTM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif INSM1 Reverse Complement Original Motif RDSCACGTGGD TGYCAGGGGGCR KGBCASGKGGHR Direction: Forward Position #: 1 Overlap #: 11 Alignment: RDSCACGTGGD- TGYCAGGGGGCR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Klf4 Reverse Complement Reverse Complement MDCCYCSTGBCR GCCYCMCCCD GCCYCHCCYRBCR Direction: Forward Position #: 2 Overlap #: 9 Alignment: -MDCCYCSTGBCR GCCYCMCCCD--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Reverse Complement KGBMKGGDGKGGC MGGTCAGGGTGACCTRDBHV MGGTCAGGGTGACCTDGBHDGGDGKGGC Direction: Forward Position #: 16 Overlap #: 5 Alignment: ---------------KGBMKGGDGKGGC MGGTCAGGGTGACCTRDBHV-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Reverse Complement MGGTCAGGGTGACCTDGBHDGGDGKGGC VAGGCCBBGGCVBB MGGTCAGVAKGMCCBGGBVBSGDGKGGC Direction: Forward Position #: 8 Overlap #: 14 Alignment: MGGTCAGGGTGACCTDGBHDGGDGKGGC -------VAGGCCBBGGCVBB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Original Motif MGGTCAGVAKGMCCBGGBVBSGDGKGGC GGGGCCCAAGGGGG MGGTCAGVGGGSCCHDVBGGGGDGKGGC Direction: Forward Position #: 9 Overlap #: 14 Alignment: MGGTCAGVAKGMCCBGGBVBSGDGKGGC --------GGGGCCCAAGGGGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Reverse Complement Reverse Complement GCCYCHCCCCBBDDGGSCCCVCTGACCY TGMYCTTTGBCCK GCCYCHCYSMYCTTKGBCCBVCTGACCY Direction: Forward Position #: 8 Overlap #: 13 Alignment: GCCYCHCCCCBBDDGGSCCCVCTGACCY -------TGMYCTTTGBCCK-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Reverse Complement GCCYCHCYSMYCTTKGBCCBVCTGACCY TGRCCTKTGHCCKAB GCCYCHCTSVCCTKTGBCCBVBTGACCY Direction: Forward Position #: 8 Overlap #: 15 Alignment: GCCYCHCYSMYCTTKGBCCBVCTGACCY -------TGRCCTKTGHCCKAB------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Reverse Complement GCCYCHCTSVCCTKTGBCCBVBTGACCY BAGGYCABHBTGACCKHV GCCYCMSKBMMCBBTGVCCKHVTGACCY Direction: Forward Position #: 5 Overlap #: 18 Alignment: GCCYCHCTSVCCTKTGBCCBVBTGACCY ----BAGGYCABHBTGACCKHV------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 41 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_5-13 INSM1 Original Motif Original Motif BKAGGGGDAD TGYCAGGGGGCR TGBBAGGGGGHR Direction: Backward Position #: 1 Overlap #: 10 Alignment: --BKAGGGGDAD TGYCAGGGGGCR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Pax5 Original Motif Reverse Complement TGBBAGGGGGHR MSGKKRCGCWDCABTGBBCD MSGKKRCGCWDCABTGBBMGGGGGHR Direction: Forward Position #: 15 Overlap #: 6 Alignment: --------------TGBBAGGGGGHR MSGKKRCGCWDCABTGBBCD------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Original Motif MSGKKRCGCWDCABTGBBMGGGGGHR BTRGGDCARAGGKCA MSGKKVHRSDDCARWGGBMRGGGGHR Direction: Forward Position #: 6 Overlap #: 15 Alignment: MSGKKRCGCWDCABTGBBMGGGGGHR -----BTRGGDCARAGGKCA------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfp423 Combined Motif Reverse Complement Reverse Complement KHCCCCKRVCCWKTGDHSMDVRYCSR GYRYCCMTKGGYRSC KHCCCSBRHCCHTTGGYRSVVRYCSR Direction: Forward Position #: 6 Overlap #: 15 Alignment: KHCCCCKRVCCWKTGDHSMDVRYCSR -----GYRYCCMTKGGYRSC------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement MSGKKVVSMKCCAAHGGDMVSGGGHR BGRRRGRGGRTGRTTYGGGG MSGKKBSGVKSSRRDKGDYHBGGGVR Direction: Forward Position #: 6 Overlap #: 20 Alignment: MSGKKVVSMKCCAAHGGDMVSGGGHR -----BGRRRGRGGRTGRTTYGGGG- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif MSGKKBSGVKSSRRDKGDYHBGGGVR RGGBCAAAGKYCA MSGKKVGGVBAVAGDKSRYHBGGGVR Direction: Forward Position #: 6 Overlap #: 13 Alignment: MSGKKBSGVKSSRRDKGDYHBGGGVR -----RGGBCAAAGKYCA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Original Motif MSGKKVGGVBAVAGDKSRYHBGGGVR RGKTCABVVRGAGGTCA MRGKTVRBVVAVAGGTSAYHBGGGVR Direction: Forward Position #: 2 Overlap #: 17 Alignment: MSGKKVGGVBAVAGDKSRYHBGGGVR -RGKTCABVVRGAGGTCA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Reverse Complement KVCCCBHMTSACCTVTVVBKVAYCMR VRVDGGHACAVDDKGTHCTDWH KVCCCBHMTSACCTVDVVBGDACMVRDKGTHCTDWH Direction: Forward Position #: 15 Overlap #: 12 Alignment: KVCCCBHMTSACCTVTVVBKVAYCMR---------- --------------VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Reverse Complement HWDAGHACRHMVRGTDCBVVHVAGGTSAYHBGGGVR MGGTCAGGGTGACCTRDBHV HWDAGHACRHMVRGTDCBVVHVAGGTCABBBKGRCVTRDBHV Direction: Forward Position #: 23 Overlap #: 14 Alignment: HWDAGHACRHMVRGTDCBVVHVAGGTSAYHBGGGVR------ ----------------------MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Original Motif Reverse Complement HWDAGHACRHMVRGTDCBVVHVAGGTCABBBKGRCVTRDBHV GGGGGYGGGG HWDAGHACRHMVRGTGBBGGYGRGGTCABBBKGRCVTRDBHV Direction: Forward Position #: 16 Overlap #: 10 Alignment: HWDAGHACRHMVRGTDCBVVHVAGGTCABBBKGRCVTRDBHV ---------------GGGGGYGGGG----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 42 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NFKB1 Tcfcp2l1 Original Motif Reverse Complement GGGGRTTCCCC CKGGDTBDMMCTGG SGGGDTBBCCCTGG Direction: Backward Position #: 4 Overlap #: 11 Alignment: GGGGRTTCCCC--- CKGGDTBDMMCTGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Reverse Complement SGGGDTBBCCCTGG GGYGCTGTCCATGGTGCTGAA GGBGCTKTCCMTGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 14 Alignment: SGGGDTBBCCCTGG------- GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif GGBGCTKTCCMTGGTGCTGAA DGVBCABTGDWGCGKRRCSR VGVGCWBTSMHGSGTRCYGRA Direction: Forward Position #: 1 Overlap #: 20 Alignment: GGBGCTKTCCMTGGTGCTGAA DGVBCABTGDWGCGKRRCSR- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Original Motif TKCMGMACSCHRSABWGCVCV CCCCMAAMCAMCCMCMMMCV HYCCVMACCMHCCMCHVCVMV Direction: Forward Position #: 1 Overlap #: 20 Alignment: TKCMGMACSCHRSABWGCVCV CCCCMAAMCAMCCMCMMMCV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Klf4 Combined Motif Original Motif Reverse Complement HYCCVMACCMHCCMCHVCVMV GCCYCMCCCD HYCCVMRCCHCMCCCHVCVMV Direction: Forward Position #: 7 Overlap #: 10 Alignment: HYCCVMACCMHCCMCHVCVMV ------GCCYCMCCCD----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Reverse Complement Original Motif VRVGVHGGGRGDGGKYBGGKD GGGGCCCAAGGGGG VGGGGBSVRRGGGGGYBGGKD Direction: Forward Position #: 2 Overlap #: 14 Alignment: VRVGVHGGGRGDGGKYBGGKD -GGGGCCCAAGGGGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SP1 Combined Motif Original Motif Reverse Complement VGGGGBSVRRGGGGGYBGGKD GGGGGYGGGG VGGGGBGGGGBGGGGYBGGKD Direction: Forward Position #: 6 Overlap #: 10 Alignment: VGGGGBSVRRGGGGGYBGGKD -----GGGGGYGGGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 7 Combined Motif Original Motif Reverse Complement VGGGGBGGGGBGGGGYBGGKD GGGGMGGG VGGGGBGGGGVGGGGYBGGKD Direction: Forward Position #: 7 Overlap #: 8 Alignment: VGGGGBGGGGBGGGGYBGGKD ------GGGGMGGG------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Zfp423 Original Motif Original Motif VGGGGBGGGGVGGGGYBGGKD GSMMCCYARGGKKKC GSMMCCBRGGGKGGVGVGGGGYBGGKD Direction: Forward Position #: 7 Overlap #: 9 Alignment: ------VGGGGBGGGGVGGGGYBGGKD GSMMCCYARGGKKKC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MZF1_5-13 Combined Motif Reverse Complement Reverse Complement HYCCVMCCCCVCVCCYCCCKBGGYRSC BTHCCCCTYB HYCCVMCCCYDCCCCYYCHKBGGYRSC Direction: Forward Position #: 10 Overlap #: 10 Alignment: HYCCVMCCCCVCVCCYCCCKBGGYRSC ---------BTHCCCCTYB-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 43 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA REST Reverse Complement Reverse Complement GTTGACCTTTGACCTTT GGYGCTGTCCATGGTGCTGAA GGYGYTGWCCTTKGWSCTKWA Direction: Forward Position #: 4 Overlap #: 17 Alignment: ---GTTGACCTTTGACCTTT- GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Reverse Complement GGYGYTGWCCTTKGWSCTKWA TGRCCTKTGHCCKAB TGRSCKYTGHCCTWBGWSCTKWA Direction: Forward Position #: 3 Overlap #: 13 Alignment: --GGYGYTGWCCTTKGWSCTKWA TGRCCTKTGHCCKAB-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Original Motif Reverse Complement TGRSCKYTGHCCTWBGWSCTKWA TGAACKCBWTGACCC TGWRCBCBHTGACCHWBGWSCTKWA Direction: Forward Position #: 3 Overlap #: 13 Alignment: --TGRSCKYTGHCCTWBGWSCTKWA TGAACKCBWTGACCC---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Reverse Complement TGWRCBCBHTGACCHWBGWSCTKWA MGGTCAGGGTGACCTRDBHV HGDDCDVBBTGACCHDBGHVCTKWA Direction: Forward Position #: 1 Overlap #: 20 Alignment: TGWRCBCBHTGACCHWBGWSCTKWA MGGTCAGGGTGACCTRDBHV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Motif 10 Original Motif Reverse Complement HGDDCDVBBTGACCHDBGHVCTKWA AAAAAAACAAARRA AAAAAAACAAWRRACDVBBTGACCHDBGHVCTKWA Direction: Forward Position #: 11 Overlap #: 4 Alignment: ----------HGDDCDVBBTGACCHDBGHVCTKWA AAAAAAACAAARRA--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif EWSR1-FLI1 Original Motif Original Motif AAAAAAACAAWRRACDVBBTGACCHDBGHVCTKWA GGAAGGAAGGAAGGAAGG GGAAGGAARRAARSAARGRACDVBBTGACCHDBGHVCTKWA Direction: Forward Position #: 7 Overlap #: 12 Alignment: ------AAAAAAACAAWRRACDVBBTGACCHDBGHVCTKWA GGAAGGAAGGAAGGAAGG----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Reverse Complement TWYAGVHCBDHGGTCABBVDGTMCMTTSMTTMMTTCCTTCC VRVDGGHACAVDDKGTHCTDWH TWYAGVHCBDVGGKYACHVDGTGYHYTBHTTMMTTCCTTCC Direction: Forward Position #: 9 Overlap #: 22 Alignment: TWYAGVHCBDHGGTCABBVDGTMCMTTSMTTMMTTCCTTCC --------VRVDGGHACAVDDKGTHCTDWH----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Original Motif GGAAGGAARRAAHBAMDMCACDVHGTKYCCBHBGHVCTKWA VHRGGTCABDBTGMCCTB GGAAGGAARRAAHBAMDMCACVVVGKKCMBBHBGHCCTBWA Direction: Forward Position #: 22 Overlap #: 18 Alignment: GGAAGGAARRAAHBAMDMCACDVHGTKYCCBHBGHVCTKWA ---------------------VHRGGTCABDBTGMCCTB-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif MIZF Original Motif Reverse Complement GGAAGGAARRAAHBAMDMCACVVVGKKCMBBHBGHCCTBWA GCGGACGTTV GCGGAMGKWARRAAHBAMDMCACVVVGKKCMBBHBGHCCTBWA Direction: Forward Position #: 3 Overlap #: 8 Alignment: --GGAAGGAARRAAHBAMDMCACVVVGKKCMBBHBGHCCTBWA GCGGACGTTV--------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Motif 9 Combined Motif Original Motif Reverse Complement GCGGAMGKWARRAAHBAMDMCACVVVGKKCMBBHBGHCCTBWA TGTGTGKVTGTGTG GCGGAMGKWARRAAHBAMDMCACVVVGKKCMBBHBGHCCTGTGTGKVTGTGTG Direction: Forward Position #: 40 Overlap #: 4 Alignment: GCGGAMGKWARRAAHBAMDMCACVVVGKKCMBBHBGHCCTBWA---------- ---------------------------------------TGTGTGKVTGTGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 44 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR4A2 NR1H2RXRA Original Motif Original Motif AAGGTCAC AAAGGTCAAAGGTCAAC AAAGGTCAMAGGTCAAC Direction: Backward Position #: 9 Overlap #: 8 Alignment: -AAGGTCAC-------- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Reverse Complement GTTGACCTYTGACCTTT MGGTCAGGGTGACCTRDBHV MGGTCAGGKTGACCTBTGACCTTT Direction: Forward Position #: 8 Overlap #: 13 Alignment: -------GTTGACCTYTGACCTTT MGGTCAGGGTGACCTRDBHV---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif MGGTCAGGKTGACCTBTGACCTTT VHRGGTCABDBTGMCCTB MGGTCADRKKKMMCTBTGACCTBT Direction: Forward Position #: 6 Overlap #: 18 Alignment: MGGTCAGGKTGACCTBTGACCTTT -----VHRGGTCABDBTGMCCTB- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif AVAGGTCABAGYRYYYMHTGACCY HWDAGHACRHHVTGTHCCHVMV AVARRKMACRBYRYGTHCYGVCCY Direction: Forward Position #: 2 Overlap #: 22 Alignment: AVAGGTCABAGYRYYYMHTGACCY -HWDAGHACRHHVTGTHCCHVMV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif MGGBCKGHACMMKBKGTRYMMTBT BTRGGDCARAGGKCA MGGBBDGBVCAVRGKKYAYMMTBT Direction: Forward Position #: 4 Overlap #: 15 Alignment: MGGBCKGHACMMKBKGTRYMMTBT ---BTRGGDCARAGGKCA------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Original Motif Original Motif MGGBBDGBVCAVRGKKYAYMMTBT TGAMCTTTGMMCYT MGGBBDGBTSAMCBTTBAHCHTBT Direction: Forward Position #: 9 Overlap #: 14 Alignment: MGGBBDGBVCAVRGKKYAYMMTBT --------TGAMCTTTGMMCYT-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif AVADGDTBAAVGYTSABCHBBCCY TTCAGCACCATGGACAGCKCC TTCAGCAMCADGGDCARVDYYSABCHBBCCY Direction: Forward Position #: 8 Overlap #: 14 Alignment: -------AVADGDTBAAVGYTSABCHBBCCY TTCAGCACCATGGACAGCKCC---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Original Motif Original Motif TTCAGCAMCADGGDCARVDYYSABCHBBCCY BBVGCCBVGGCCTV TTCAGCAMCADGGDCARVDYBSVBCCBVSSCCTV Direction: Forward Position #: 21 Overlap #: 11 Alignment: TTCAGCAMCADGGDCARVDYYSABCHBBCCY--- --------------------BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Reverse Complement Reverse Complement VAGGSSVBGGBBSBKHVMTGDCCDTGRTGCTGAA BGRRRGRGGRTGRTTYGGGG BGRVAGGSGRTGGYTBGGVGMTGDCCDTGRTGCTGAA Direction: Forward Position #: 4 Overlap #: 17 Alignment: ---VAGGSSVBGGBBSBKHVMTGDCCDTGRTGCTGAA BGRRRGRGGRTGRTTYGGGG----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Reverse Complement Original Motif TTCAGCAMCADGGDCARCVCCVAMCCAMCSCCTVMCB CCAGYYHVADCCRG TTCAGCAMCADGGCCAGHBCVADCCVRMCSCCTVMCB Direction: Forward Position #: 14 Overlap #: 14 Alignment: TTCAGCAMCADGGDCARCVCCVAMCCAMCSCCTVMCB -------------CCAGYYHVADCCRG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 45 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 ESR1 Reverse Complement Reverse Complement MSGKKRCGCWDCABTGBBCD MGGTCAGGGTGACCTRDBHV MGGTBAVGCTKVMCTGBBMD Direction: Backward Position #: 1 Overlap #: 20 Alignment: MSGKKRCGCWDCABTGBBCD MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement MGGTBAVGCTKVMCTGBBMD VRVDGGHACAVDDKGTHCTDWH MGGTBAVGSDBVVSTRCHVDDKGTHCTDWH Direction: Forward Position #: 9 Overlap #: 12 Alignment: MGGTBAVGCTKVMCTGBBMD---------- --------VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Reverse Complement MGGTBAVGSDBVVSTRCHVDDKGTHCTDWH BAGGYCABHBTGACCKHV MGGTBVMGGDVABBBWSACBKTGTHCTDWH Direction: Forward Position #: 6 Overlap #: 18 Alignment: MGGTBAVGSDBVVSTRCHVDDKGTHCTDWH -----BAGGYCABHBTGACCKHV------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Original Motif Reverse Complement MGGTBVMGGDVABBBWSACBKTGTHCTDWH GGYGCTGTCCATGGTGCTGAA MGGTBVMGGDVHVCTKKMCHTKGTBCTKAH Direction: Forward Position #: 10 Overlap #: 21 Alignment: MGGTBVMGGDVABBBWSACBKTGTHCTDWH ---------GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Reverse Complement Original Motif HTYAGBACYAHGRRYAGVHVHCCYBBACCY RGKTCABVVRGAGGTCA HTYAGBWCMDBGRRHRGBCAHCCYBBACCY Direction: Forward Position #: 4 Overlap #: 17 Alignment: HTYAGBACYAHGRRYAGVHVHCCYBBACCY ---RGKTCABVVRGAGGTCA---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Reverse Complement Reverse Complement MGGTBVMGGDTGVCMHMKCBDYGWBCTKAH BGRRRGRGGRTGRTTYGGGG HGGDBRVGGRTGRYYYGGSGDYGWBCTKAH Direction: Forward Position #: 1 Overlap #: 20 Alignment: MGGTBVMGGDTGVCMHMKCBDYGWBCTKAH BGRRRGRGGRTGRTTYGGGG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Reverse Complement HTYAGBWCMDCSCCMMKKCAMCCBMBHCCD TGRCCTKTGHCCKAB HTYAGBWCMDCSCCMMKKYRVCCTBTBCCVKAB Direction: Forward Position #: 19 Overlap #: 12 Alignment: HTYAGBWCMDCSCCMMKKCAMCCBMBHCCD--- ------------------TGRCCTKTGHCCKAB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Reverse Complement Original Motif BTRVGGBAVAGGBKMRYYYGGSGDYGWBCTKAH GGGGCCCAAGGGGG GKGGSSHAMRGGGGMRYYYGGSGDYGWBCTKAH Direction: Forward Position #: 1 Overlap #: 14 Alignment: BTRVGGBAVAGGBKMRYYYGGSGDYGWBCTKAH GGGGCCCAAGGGGG------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Original Motif Original Motif GKGGSSHAMRGGGGMRYYYGGSGDYGWBCTKAH TGAMCTTTGMMCYT GKGGSSHAMRGKGRMCYTTGVVSHTGWBCTKAH Direction: Forward Position #: 12 Overlap #: 14 Alignment: GKGGSSHAMRGGGGMRYYYGGSGDYGWBCTKAH -----------TGAMCTTTGMMCYT-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Reverse Complement GKGGSSHAMRGKGRMCYTTGVVSHTGWBCTKAH TGMYCTTTGBCCK GKGGSSHAMRGKKRMCYTTKGVVCBGWBCTKAH Direction: Forward Position #: 13 Overlap #: 13 Alignment: GKGGSSHAMRGKGRMCYTTGVVSHTGWBCTKAH ------------TGMYCTTTGBCCK-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 46 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RORA_1 ESR1 Reverse Complement Reverse Complement TGACCTDVWT MGGTCAGGGTGACCTRDBHV MGGTCAGGGTGACCTDDDHV Direction: Backward Position #: 2 Overlap #: 10 Alignment: ---------TGACCTDVWT- MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Original Motif Original Motif MGGTCAGGGTGACCTDDDHV GGGTCAWBGRGTTCA RGGTCADBGDGWYCDDDDHV Direction: Forward Position #: 1 Overlap #: 15 Alignment: MGGTCAGGGTGACCTDDDHV GGGTCAWBGRGTTCA----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Original Motif Original Motif RGGTCADBGDGWYCDDDDHV AAAGGTCAAAGGTCAAC AAAGGTCAAAGGTCAABGDGWYCDDDDHV Direction: Forward Position #: 10 Overlap #: 8 Alignment: ---------RGGTCADBGDGWYCDDDDHV AAAGGTCAAAGGTCAAC------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Reverse Complement Original Motif VHDHHDGKWCDCBTTGACCTTTGACCTTT RGKTCABVVRGAGGTCA VHDHHRGKTCAHVDWGASSTYWGACCTTT Direction: Forward Position #: 6 Overlap #: 17 Alignment: VHDHHDGKWCDCBTTGACCTTTGACCTTT -----RGKTCABVVRGAGGTCA------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Original Motif Reverse Complement VHDHHRGKTCAHVDWGASSTYWGACCTTT AKGYYCAAAGRTCA AKGBHCAAAGGTCAHVDWGASSTYWGACCTTT Direction: Forward Position #: 4 Overlap #: 11 Alignment: ---VHDHHRGKTCAHVDWGASSTYWGACCTTT AKGYYCAAAGRTCA------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Original Motif AKGBHCAAAGGTCAHVDWGASSTYWGACCTTT BTRGGDCARAGGKCA AKGBHBHARGDYMAVGGTSASSTYWGACCTTT Direction: Forward Position #: 6 Overlap #: 15 Alignment: AKGBHCAAAGGTCAHVDWGASSTYWGACCTTT -----BTRGGDCARAGGKCA------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Original Motif Original Motif AKGBHBHARGDYMAVGGTSASSTYWGACCTTT TTCAGCACCATGGACAGCKCC AKGBBBCAGSACCAHGGWSAGCKYHGACCTTT Direction: Forward Position #: 5 Overlap #: 21 Alignment: AKGBHBHARGDYMAVGGTSASSTYWGACCTTT ----TTCAGCACCATGGACAGCKCC------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Reverse Complement Original Motif AAAGGTCDKRGCTSWCCHTGGTSCTGVVBCYT RGGBCAAAGKYCA AAAGGTCDKRGVKGBCMAWGKTCMTGVVBCYT Direction: Forward Position #: 12 Overlap #: 13 Alignment: AAAGGTCDKRGCTSWCCHTGGTSCTGVVBCYT -----------RGGBCAAAGKYCA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Original Motif Reverse Complement AAAGGTCDKRGVKGBCMAWGKTCMTGVVBCYT VRVDGGHACAVDDKGTHCTDWH AAAGGTCDKRGVKGBCMADGBBSGTRCAVBHTGTHCTDWH Direction: Forward Position #: 19 Overlap #: 14 Alignment: AAAGGTCDKRGVKGBCMAWGKTCMTGVVBCYT-------- ------------------VRVDGGHACAVDDKGTHCTDWH ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Reverse Complement Original Motif HWDAGHACAHBVTGKACSVBCDTYGVCRVCKYHGACCTTT CCCCMAAMCAMCCMCMMMCV CCHCARAMCAMCCHSHMMSVBCDTYGVCRVCKYHGACCTTT Direction: Forward Position #: 2 Overlap #: 19 Alignment: -HWDAGHACAHBVTGKACSVBCDTYGVCRVCKYHGACCTTT CCCCMAAMCAMCCMCMMMCV--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 47 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 ESR1 Original Motif Reverse Complement RGKTCABVVRGAGGTCA MGGTCAGGGTGACCTRDBHV MGGDSRKSRTGRMCDGGBCA Direction: Backward Position #: 1 Overlap #: 17 Alignment: ---RGKTCABVVRGAGGTCA MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Original Motif TGVCCDGRKCAKSRKSDCCY VHRGGTCABDBTGMCCTB BDRBSTCABVDTGAHCHCCY Direction: Forward Position #: 1 Overlap #: 18 Alignment: TGVCCDGRKCAKSRKSDCCY VHRGGTCABDBTGMCCTB-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Reverse Complement Original Motif MGGHGDTCADVBTGASBKHV DGVBCABTGDWGCGKRRCSR MGGHGDTCADGBKSASBKHDGCGKRRCSR Direction: Forward Position #: 10 Overlap #: 11 Alignment: MGGHGDTCADVBTGASBKHV--------- ---------DGVBCABTGDWGCGKRRCSR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ar Combined Motif Reverse Complement Original Motif MSGKKRCGCDHYVSTSRBCDTGAHCHCCY HWDAGHACRHHVTGTHCCHVMV MSGKKRCGCDHYVSHDDVGHWCAHCBYSTHCCHVMV Direction: Forward Position #: 15 Overlap #: 15 Alignment: MSGKKRCGCDHYVSTSRBCDTGAHCHCCY------- --------------HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Reverse Complement MSGKKRCGCDHYVSHDDVGHWCAHCBYSTHCCHVMV TGRCCTKTGHCCKAB MSGKKRCGCDHYVSHDDVGHTSACCTBKBHCCDVVV Direction: Forward Position #: 21 Overlap #: 15 Alignment: MSGKKRCGCDHYVSHDDVGHWCAHCBYSTHCCHVMV --------------------TGRCCTKTGHCCKAB- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RXRAVDR Reverse Complement Original Motif VVBDGGDVRVAGGTSAHCBDHHSBKHDGCGKRYCSR GGGTCAWBGRGTTCA GGGTCRDBGRGTDCAAGGTSAHCBDHHSBKHDGCGKRYCSR Direction: Forward Position #: 6 Overlap #: 10 Alignment: -----VVBDGGDVRVAGGTSAHCBDHHSBKHDGCGKRYCSR GGGTCAWBGRGTTCA-------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Reverse Complement Original Motif MSGKKRCGCDHYVSHDDVGHTSACCTTGDACMCBDKGACCC TGAMCTTTGMMCYT MSGKKRCGCDHYVKGAMCBTTGAMCHTGDACMCBDKGACCC Direction: Forward Position #: 14 Overlap #: 14 Alignment: MSGKKRCGCDHYVSHDDVGHTSACCTTGDACMCBDKGACCC -------------TGAMCTTTGMMCYT-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLAG1 Combined Motif Original Motif Reverse Complement MSGKKRCGCDHYVKGAMCBTTGAMCHTGDACMCBDKGACCC CCCCCTTGGGCCCC MSGKKRCGCDHYVKGAMCBTYSCCCYTGDRCCCCDKGACCC Direction: Forward Position #: 21 Overlap #: 14 Alignment: MSGKKRCGCDHYVKGAMCBTTGAMCHTGDACMCBDKGACCC --------------------CCCCCTTGGGCCCC------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Reverse Complement MSGKKRCGCDHYVKGAMCBTYSCCCYTGDRCCCCDKGACCC TGMYCTTTGBCCK MSGKKRCGCDHYVTGAHCTTTSVCCBTGDRCCCCDKGACCC Direction: Forward Position #: 14 Overlap #: 13 Alignment: MSGKKRCGCDHYVKGAMCBTYSCCCYTGDRCCCCDKGACCC -------------TGMYCTTTGBCCK--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RREB1 Combined Motif Reverse Complement Reverse Complement GGGTCRDGGGGMHCAVGGVSAAAGDTCABKHDGCGKRYCSR BGRRRGRGGRTGRTTYGGGG GGGTCRDGGGGMHCAHGGVVRRRGRTSRYTHGGSGKRYCSR Direction: Forward Position #: 16 Overlap #: 20 Alignment: GGGTCRDGGGGMHCAVGGVSAAAGDTCABKHDGCGKRYCSR ---------------BGRRRGRGGRTGRTTYGGGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- *************************************************************** Combined Motifs for Top Best Match Motif ID 48 and Its Best Matches ************************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Ar Original Motif Original Motif CCAGYYHVADCCRG HWDAGHACRHHVTGTHCCHVMV HWDAGHMCAGYBYGWDCCDGMV Direction: Backward Position #: 3 Overlap #: 14 Alignment: ------CCAGYYHVADCCRG-- HWDAGHACRHHVTGTHCCHVMV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Original Motif VRCDGGDWCMBKCTGRHCTDWH VDBHMAGGTCACCCTGACCY VRCDGGDWCMVDBBGRDSTHAHCCTGACCY Direction: Forward Position #: 11 Overlap #: 12 Alignment: VRCDGGDWCMBKCTGRHCTDWH-------- ----------VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Zfx Combined Motif Reverse Complement Original Motif MGGTCAGGDTDASHKCVBHVYGWDCCDGMV BBVGCCBVGGCCTV MGGTCAGGDTDASHKCVBHBBGDVCBVGVCCTV Direction: Forward Position #: 20 Overlap #: 11 Alignment: MGGTCAGGDTDASHKCVBHVYGWDCCDGMV--- -------------------BBVGCCBVGGCCTV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif RREB1 Reverse Complement Reverse Complement VAGGVCBBGVHCBBDBBGRDSTHAHCCTGACCY BGRRRGRGGRTGRTTYGGGG BGRRRGRGGRTGRTTYGRGGVCBBGVHCBBDBBGRDSTHAHCCTGACCY Direction: Forward Position #: 17 Overlap #: 4 Alignment: ----------------VAGGVCBBGVHCBBDBBGRDSTHAHCCTGACCY BGRRRGRGGRTGRTTYGGGG----------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PLAG1 Original Motif Original Motif BGRRRGRGGRTGRTTYGRGGVCBBGVHCBBDBBGRDSTHAHCCTGACCY GGGGCCCAAGGGGG GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHCBBDBBGRDSTHAHCCTGACCY Direction: Forward Position #: 5 Overlap #: 10 Alignment: ----BGRRRGRGGRTGRTTYGRGGVCBBGVHCBBDBBGRDSTHAHCCTGACCY GGGGCCCAAGGGGG--------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Original Motif GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHCBBDBBGRDSTHAHCCTGACCY VHRGGTCABDBTGMCCTB GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGGYCAVDSTVACCYTGACCY Direction: Forward Position #: 31 Overlap #: 18 Alignment: GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHCBBDBBGRDSTHAHCCTGACCY ------------------------------VHRGGTCABDBTGMCCTB----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Original Motif Reverse Complement GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGGYCAVDSTVACCYTGACCY TGRCCTKTGHCCKAB GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGRYCDDTSBCMBMBTGACCY Direction: Forward Position #: 33 Overlap #: 15 Alignment: GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGGYCAVDSTVACCYTGACCY --------------------------------TGRCCTKTGHCCKAB------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pax5 Combined Motif Original Motif Original Motif GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGRYCDDTSBCMBMBTGACCY DGVBCABTGDWGCGKRRCSR GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGVBCDBTGDHGBVBDGMCVY Direction: Forward Position #: 33 Overlap #: 20 Alignment: GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGRYCDDTSBCMBMBTGACCY --------------------------------DGVBCABTGDWGCGKRRCSR- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RXRRAR_DR5 Combined Motif Original Motif Reverse Complement GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGVBCDBTGDHGBVBDGMCVY TGACCTCKVVBTGAYCK GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHTGAYCTVTVVDKSAYCKMCVY Direction: Forward Position #: 33 Overlap #: 17 Alignment: GGGGCSVARGGGGGTGRTTYGRGGVCBBGVHHDGVBCDBTGDHGBVBDGMCVY --------------------------------TGACCTCKVVBTGAYCK---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Original Motif MVGRYGMTSRDVVAVAGKTCADDVCBVGVCCKCMAAMCACCCCCKTVSGCCCC TTCAGCACCATGGACAGCKCC TTCAGCACCABGGMSAKCDVHVAVAGKTCADDVCBVGVCCKCMAAMCACCCCCKTVSGCCCC Direction: Forward Position #: 10 Overlap #: 12 Alignment: ---------MVGRYGMTSRDVVAVAGKTCADDVCBVGVCCKCMAAMCACCCCCKTVSGCCCC TTCAGCACCATGGACAGCKCC----------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Results created by MOTIFSIM on 11-20-2016 21:31:13 Runtime: 756.479 seconds MOTIFSIM is written by Ngoc Tam L. 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