**************************************************************************************************************************************************************************************************** MOTIFSIM - Motif Similarity Detection Tool Version 2.2 **************************************************************************************************************************************************************************************************** INPUT **************************************************************************************************************************************************************************************************** Input Parameters Number of files: 2 Number of top significant motifs: 10 Number of best matches: 10 Similarity cutoff: >= 0.75 Matching motif database: UniProbe Mus Musculus Motif tree: Yes Combined similar motifs: Yes Output file type: All Output file format: All Input files and motif counts File name Count of motifs Dataset # PScanChIP_DM05.txt 16 1 RSAT_peak-motifs_DM05.txt 17 2 **************************************************************************************************************************************************************************************************** RESULTS **************************************************************************************************************************************************************************************************** ************************************************************ Combined Motifs for Top Global Significant Motif ID 5 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZEB1 AmTGTGACACCACAGT Reverse Complement Reverse Complement HAGGTG ACTGTGGTGTCACART ACTBWGGTGTCACART Direction: Forward Position #: 4 Overlap #: 6 Alignment: ---HAGGTG------- ACTGTGGTGTCACART ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TgTGgTGTCACAGTGCTCC Original Motif Reverse Complement ACTBWGGTGTCACART GGAGCACTGTGACACCACA RSWGHRSTGTSACAVYACA Direction: Forward Position #: 1 Overlap #: 16 Alignment: ACTBWGGTGTCACART--- GGAGCACTGTGACACCACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AgTGCTCCACTGTGgTGTCACAgT Original Motif Reverse Complement RSWGHRSTGTSACAVYACA ACTGTGACACCACAGTGGAGCACT ASTGTGAYRYCACAGTRSAGCACT Direction: Forward Position #: 1 Overlap #: 19 Alignment: RSWGHRSTGTSACAVYACA----- ACTGTGACACCACAGTGGAGCACT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- srACyCCGAyr Combined Motif Original Motif Original Motif ASTGTGAYRYCACAGTRSAGCACT SRACYCCGAYR YCACAGTRSAGCACTACTSYGAYRASTGTGAYRYCACAG Direction: Backward Position #: 16 Overlap #: 9 Alignment: --ASTGTGAYRYCACAGTRSAGCACT ---------------SRACYCCGAYR ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TGGAGCACTGTGACAcCACAGTGg Original Motif Reverse Complement YCACAGTRSAGCACTACTSYGAYRASTGTGAYRYCACAG CCACTGTGVTGTCACAGTGCTCCA YCACWGTGSWGYMMYASTSCKMCAASTGTGAYRYCACAG Direction: Forward Position #: 1 Overlap #: 24 Alignment: YCACAGTRSAGCACTACTSYGAYRASTGTGAYRYCACAG CCACTGTGVTGTCACAGTGCTCCA--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CAcCACAGTGGAGCAct Original Motif Original Motif YCACWGTGSWGYMMYASTSCKMCAASTGTGAYRYCACAG CAHCACAGTGGAGCACT CAHCACAGTGGAGYAMYASTSCKMCAASTGTGAYRYCACAG Direction: Forward Position #: 3 Overlap #: 15 Alignment: --YCACWGTGSWGYMMYASTSCKMCAASTGTGAYRYCACAG CAHCACAGTGGAGCACT------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- atactttggc Combined Motif Original Motif Reverse Complement CAHCACAGTGGAGYAMYASTSCKMCAASTGTGAYRYCACAG GCCAAAGTAT CRCCAMAGTRKAGYAMYASTSCKMCAASTGTGAYRYCACAG Direction: Forward Position #: 2 Overlap #: 10 Alignment: CAHCACAGTGGAGYAMYASTSCKMCAASTGTGAYRYCACAG -GCCAAAGTAT------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CACTGTGrYrtCACAGTGswsCAcT Combined Motif Original Motif Original Motif CRCCAMAGTRKAGYAMYASTSCKMCAASTGTGAYRYCACAG CACTGTGRTRTCACAGTGSWSCACT CRCCACWGTGDWGYMACAGTGCTVCAVBTGTGAYRYCACAG Direction: Forward Position #: 4 Overlap #: 25 Alignment: CRCCAMAGTRKAGYAMYASTSCKMCAASTGTGAYRYCACAG ---CACTGTGRTRTCACAGTGSWSCACT------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ssCCCCGCSssk Reverse Complement Reverse Complement CTGTGMKMTCACAVBTGVAGCACTGTRMCWHCACWGTGGMG BBSGGCGGGGBS GGGBSHBSRSMGCTGTGMKMTCACAVBTGVAGCACTGTRMCWHCAC Direction: Backward Position #: 6 Overlap #: 7 Alignment: CTGTGMKMTCACAVBTGVAGCACTGTRMCWHCACWGTGGMG----- ----------------------------------BBSGGCGGGGBS ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CagTGCTCCACTGTGgT Combined Motif Original Motif Original Motif GGGBSHBSRSMGCTGTGMKMTCACAVBTGVAGCACTGTRMCWHCAC CAGTGCTCCACTGTGBT GGSVGTGCDCCRCTGTGVTMTCACAVBTGVAGCACTGTRMCWHCAC Direction: Forward Position #: 3 Overlap #: 17 Alignment: GGGBSHBSRSMGCTGTGMKMTCACAVBTGVAGCACTGTRMCWHCAC --CAGTGCTCCACTGTGBT--------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 6 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn sscCCCGCGcs Reverse Complement Original Motif GCCACGTGSD BSCCCCGCGBS SCCMCGYGSVB Direction: Backward Position #: 1 Overlap #: 10 Alignment: -GCCACGTGSD BSCCCCGCGBS ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ssCCCCGCSssk Reverse Complement Reverse Complement BVSCKCGRGGS BBSGGCGGGGBS BBSSGCGGGGSS Direction: Forward Position #: 1 Overlap #: 11 Alignment: BVSCKCGRGGS- BBSGGCGGGGBS ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CACTGTGrYrtCACAGTGswsCAcT Combined Motif Reverse Complement Original Motif SSCCCCGCSSBB CACTGTGRTRTCACAGTGSWSCACT SSCMCYGYGVBVTCACAGTGSWSCACT Direction: Forward Position #: 3 Overlap #: 10 Alignment: SSCCCCGCSSBB--------------- --CACTGTGRTRTCACAGTGSWSCACT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CagTGCTCCACTGTGgT Reverse Complement Original Motif AGTGSWSCACTGTGAVVVCMCMGRGSS CAGTGCTCCACTGTGBT CAGTGCTSCACTGTGVHVVCMCMGRGSS Direction: Forward Position #: 2 Overlap #: 16 Alignment: -AGTGSWSCACTGTGAVVVCMCMGRGSS CAGTGCTCCACTGTGBT----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AgTGCTCCACTGTGgTGTCACAgT Reverse Complement Original Motif SSCMCYGYGVBHBCACAGTGSAGCACTG AGTGCTCCACTGTGGTGTCACAGT AGTGCTCCACTGTGVTVTCACAGTGSAGCACTG Direction: Forward Position #: 6 Overlap #: 19 Alignment: -----SSCMCYGYGVBHBCACAGTGSAGCACTG AGTGCTCCACTGTGGTGTCACAGT--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TGGAGCACTGTGACAcCACAGTGg Combined Motif Reverse Complement Reverse Complement CAGTGCTSCACTGTGAVAVCACAGTGGAGCACT CCACTGTGVTGTCACAGTGCTCCA CAGTGCTCCACTGTGVTRTCACAGTGSWSCACT Direction: Forward Position #: 8 Overlap #: 24 Alignment: CAGTGCTSCACTGTGAVAVCACAGTGGAGCACT -------CCACTGTGVTGTCACAGTGCTCCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CAcCACAGTGGAGCAct Reverse Complement Reverse Complement AGTGSWSCACTGTGAMABCACAGTGGAGCACTG AGTGCTCCACTGTGDTG AGTGCTCCACTGTGVHVBCACAGTGGAGCACTG Direction: Forward Position #: 1 Overlap #: 17 Alignment: AGTGSWSCACTGTGAMABCACAGTGGAGCACTG AGTGCTCCACTGTGDTG---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif gCGCGCsCgsG Reverse Complement Original Motif CAGTGCTCCACTGTGVVHBCACAGTGGAGCACT GCGCGCSCGCG CGCGVSKSGMGCAGTGCTCCACTGTGVVHBCACAGTG Direction: Backward Position #: 5 Overlap #: 7 Alignment: CAGTGCTCCACTGTGVVHBCACAGTGGAGCACT---- --------------------------GCGCGCSCGCG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TgTGgTGTCACAGTGCTCC Combined Motif Original Motif Reverse Complement CGCGVSKSGMGCAGTGCTCCACTGTGVVHBCACAGTG GGAGCACTGTGACACCACA CGCGVSKGGAGCASTGYKMCACYRYRVVHBCACAGTG Direction: Forward Position #: 8 Overlap #: 19 Alignment: CGCGVSKSGMGCAGTGCTCCACTGTGVVHBCACAGTG -------GGAGCACTGTGACACCACA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ssGCkTGCssk Combined Motif Original Motif Original Motif CGCGVSKGGAGCASTGYKMCACYRYRVVHBCACAGTG SSGCKTGCSSK CGCGVSGCGWGCVSTGYKMCACYRYRVVHBCACAGTG Direction: Forward Position #: 5 Overlap #: 11 Alignment: CGCGVSKGGAGCASTGYKMCACYRYRVVHBCACAGTG ----SSGCKTGCSSK---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 8 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Myc sscCCCGCGcs Reverse Complement Original Motif DCCACGTGCV BSCCCCGCGBS VCCMCGYGCVB Direction: Backward Position #: 1 Overlap #: 10 Alignment: -DCCACGTGCV BSCCCCGCGBS ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ssCCCCGCSssk Reverse Complement Reverse Complement BVGCKCGRGGV BBSGGCGGGGBS BBSSGCGGGGBS Direction: Forward Position #: 1 Overlap #: 11 Alignment: BVGCKCGRGGV- BBSGGCGGGGBS ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CACTGTGrYrtCACAGTGswsCAcT Combined Motif Reverse Complement Original Motif SBCCCCGCSSBB CACTGTGRTRTCACAGTGSWSCACT SBCMCYGYGVBVTCACAGTGSWSCACT Direction: Forward Position #: 3 Overlap #: 10 Alignment: SBCCCCGCSSBB--------------- --CACTGTGRTRTCACAGTGSWSCACT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CagTGCTCCACTGTGgT Reverse Complement Original Motif AGTGSWSCACTGTGAVVVCMCMGRGBS CAGTGCTCCACTGTGBT CAGTGCTSCACTGTGVHVVCMCMGRGBS Direction: Forward Position #: 2 Overlap #: 16 Alignment: -AGTGSWSCACTGTGAVVVCMCMGRGBS CAGTGCTCCACTGTGBT----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TGGAGCACTGTGACAcCACAGTGg Reverse Complement Original Motif SBCMCYGYGVBHBCACAGTGSAGCACTG TGGAGCACTGTGACAVCACAGTGG TGGVGCACTGTGACABCACAGTGGAGCACTG Direction: Forward Position #: 4 Overlap #: 21 Alignment: ---SBCMCYGYGVBHBCACAGTGSAGCACTG TGGAGCACTGTGACAVCACAGTGG------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- wwCCAmAGTCmt Combined Motif Original Motif Original Motif TGGVGCACTGTGACABCACAGTGGAGCACTG DDCCAMAGTCHB TGRHCCACWGTSVBABCACAGTGGAGCACTG Direction: Forward Position #: 3 Overlap #: 12 Alignment: TGGVGCACTGTGACABCACAGTGGAGCACTG --DDCCAMAGTCHB----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CAcCACAGTGGAGCAct Original Motif Reverse Complement TGRHCCACWGTSVBABCACAGTGGAGCACTG AGTGCTCCACTGTGDTG AGTGSTCCACWGTGVTRBCACAGTGGAGCACTG Direction: Forward Position #: 3 Overlap #: 15 Alignment: --TGRHCCACWGTSVBABCACAGTGGAGCACTG AGTGCTCCACTGTGDTG---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AgTGCTCCACTGTGgTGTCACAgT Original Motif Original Motif AGTGSTCCACWGTGVTRBCACAGTGGAGCACTG AGTGCTCCACTGTGGTGTCACAGT AGTGCTCCACTGTGVTGTCACAGTGGAGCACTG Direction: Forward Position #: 1 Overlap #: 24 Alignment: AGTGSTCCACWGTGVTRBCACAGTGGAGCACTG AGTGCTCCACTGTGGTGTCACAGT--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- gCGCGCsCgsG Combined Motif Original Motif Reverse Complement AGTGCTCCACTGTGVTGTCACAGTGGAGCACTG CGCGSGCGCGC AGTGCTCCACTGTGVTGTCACAGTGGAGCRCKSGCGCGC Direction: Forward Position #: 29 Overlap #: 5 Alignment: AGTGCTCCACTGTGVTGTCACAGTGGAGCACTG------ ----------------------------CGCGSGCGCGC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TgTGgTGTCACAGTGCTCC Original Motif Original Motif AGTGCTCCACTGTGVTGTCACAGTGGAGCRCKSGCGCGC TGTGGTGTCACAGTGCTCC TRKKGYKYCACWGTGBTSYCACAGTGGAGCRCKSGCGCGC Direction: Forward Position #: 2 Overlap #: 18 Alignment: -AGTGCTCCACTGTGVTGTCACAGTGGAGCRCKSGCGCGC TGTGGTGTCACAGTGCTCC--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 11 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR4A2 CACTGTGrYrtCACAGTGswsCAcT Original Motif Original Motif AAGGTCAC CACTGTGRTRTCACAGTGSWSCACT CACTGTRAKGTCACAGTGSWSCACT Direction: Forward Position #: 7 Overlap #: 8 Alignment: ------AAGGTCAC----------- CACTGTGRTRTCACAGTGSWSCACT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TGGAGCACTGTGACAcCACAGTGg Original Motif Reverse Complement CACTGTRAKGTCACAGTGSWSCACT CCACTGTGVTGTCACAGTGCTCCA CCACTGTGRTGTCACAGTGCTCCACT Direction: Forward Position #: 2 Overlap #: 23 Alignment: -CACTGTRAKGTCACAGTGSWSCACT CCACTGTGVTGTCACAGTGCTCCA-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AmTGTGACACCACAGT Reverse Complement Original Motif AGTGGAGCACTGTGACAKCACAGTGG AMTGTGACACCACAGT AMTRKKRSASCACWGTGACAKCACAGTGG Direction: Forward Position #: 4 Overlap #: 13 Alignment: ---AGTGGAGCACTGTGACAKCACAGTGG AMTGTGACACCACAGT------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TgTGgTGTCACAGTGCTCC Reverse Complement Reverse Complement CCACTGTGRTGTCACWGTGSTSKYRMART GGAGCACTGTGACACCACA GGASCACTGTGAYRYCACWGTGSTSKYRMART Direction: Forward Position #: 4 Overlap #: 16 Alignment: ---CCACTGTGRTGTCACWGTGSTSKYRMART GGAGCACTGTGACACCACA------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AgTGCTCCACTGTGgTGTCACAgT Reverse Complement Reverse Complement AMTRKKRSASCACWGTGMKKTCACAGTGSTCC ACTGTGACACCACAGTGGAGCACT ACTGTGACACCACAGTGVWGYMMYAGTGSTCC Direction: Forward Position #: 1 Overlap #: 24 Alignment: AMTRKKRSASCACWGTGMKKTCACAGTGSTCC ACTGTGACACCACAGTGGAGCACT-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- cCGCGGrCACG Combined Motif Reverse Complement Reverse Complement GGASCACTKYYKCWVCACTGTGGTGTCACAGT CGTGKCCGCGG GGASCACTKCBKSKCCRCKGTGGTGTCACAGT Direction: Forward Position #: 10 Overlap #: 11 Alignment: GGASCACTKYYKCWVCACTGTGGTGTCACAGT ---------CGTGKCCGCGG------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- wwCCAmAGTCmt Combined Motif Original Motif Original Motif GGASCACTKCBKSKCCRCKGTGGTGTCACAGT DDCCAMAGTCHB GDACCACWGTCBBKCCRCKGTGGTGTCACAGT Direction: Forward Position #: 2 Overlap #: 12 Alignment: GGASCACTKCBKSKCCRCKGTGGTGTCACAGT -DDCCAMAGTCHB------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CagTGCTCCACTGTGgT Combined Motif Original Motif Original Motif GDACCACWGTCBBKCCRCKGTGGTGTCACAGT CAGTGCTCCACTGTGBT GDACCACHRBYGCTCCACTGTGGTGTCACAGT Direction: Forward Position #: 8 Overlap #: 17 Alignment: GDACCACWGTCBBKCCRCKGTGGTGTCACAGT -------CAGTGCTCCACTGTGBT-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 25 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- wwCCAmAGTCmt HNF4A Original Motif Original Motif DDCCAMAGTCHB RGGBCAAAGKYCA RGDCCAMAGTCCD Direction: Forward Position #: 2 Overlap #: 12 Alignment: -DDCCAMAGTCHB RGGBCAAAGKYCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Reverse Complement DGGACTYTGGHCK GGYGCTGTCCATGGTGCTGAA DGBRCTKTSSHHGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 13 Alignment: DGGACTYTGGHCK-------- GGYGCTGTCCATGGTGCTGAA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Reverse Complement DGBRCTKTSSHHGGTGCTGAA MGGTCAGGGTGACCTRDBHV MGGTBRBRCTGWCCHDGGTVCTGAA Direction: Forward Position #: 5 Overlap #: 16 Alignment: ----DGBRCTKTSSHHGGTGCTGAA MGGTCAGGGTGACCTRDBHV----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA Combined Motif Original Motif Reverse Complement MGGTBRBRCTGWCCHDGGTVCTGAA GTTGACCTTTGACCTTT AGBTGACCTTTGWCCTKWMGGTBRB Direction: Backward Position #: 2 Overlap #: 17 Alignment: MGGTBRBRCTGWCCHDGGTVCTGAA -------GTTGACCTTTGACCTTT- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Original Motif BKBACCYWYAGGWCAAAGGTCAVCT BTRGGDCARAGGKCA BTVRSBYAHAGGTCAAAGGTCAVCT Direction: Forward Position #: 1 Overlap #: 15 Alignment: BKBACCYWYAGGWCAAAGGTCAVCT BTRGGDCARAGGKCA---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Reverse Complement Original Motif AGBTGACCTTTGACCTHTKBSMVAB TGAMCTTTGMMCYT AGBTGACCTTTGACCTBTKBSMVAB Direction: Forward Position #: 4 Overlap #: 14 Alignment: AGBTGACCTTTGACCTHTKBSMVAB ---TGAMCTTTGMMCYT-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CTCF Combined Motif Original Motif Reverse Complement AGBTGACCTTTGACCTBTKBSMVAB BMSMGCCYMCTKSTGGMHM AGBTGDMCHKYSHMCTBBTGGMHAB Direction: Forward Position #: 6 Overlap #: 19 Alignment: AGBTGACCTTTGACCTBTKBSMVAB -----BMSMGCCYMCTKSTGGMHM- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Reverse Complement AGBTGDMCHKYSHMCTBBTGGMHAB BAGGYCABHBTGACCKHV AGBTGHMSBBCVHCCTGDYSKHVAB Direction: Forward Position #: 6 Overlap #: 18 Alignment: AGBTGDMCHKYSHMCTBBTGGMHAB -----BAGGYCABHBTGACCKHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Esrrb Original Motif Original Motif AGBTGHMSBBCVHCCTGDYSKHVAB VBBYCAAGGTCA DBBTSAAGGTCAHCCTGDYSKHVAB Direction: Forward Position #: 1 Overlap #: 12 Alignment: AGBTGHMSBBCVHCCTGDYSKHVAB VBBYCAAGGTCA------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Original Motif DBBTSAAGGTCAHCCTGDYSKHVAB VGCACGTGGH VGCWCRWGGHCAHCCTGDYSKHVAB Direction: Forward Position #: 1 Overlap #: 10 Alignment: DBBTSAAGGTCAHCCTGDYSKHVAB VGCACGTGGH--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 28 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ssGCkTGCssk CTCF Original Motif Original Motif SSGCKTGCSSK YDRCCASYAGRKGGCRSYV YDRCCASSVGSKKGCGSKV Direction: Forward Position #: 8 Overlap #: 11 Alignment: -------SSGCKTGCSSK- YDRCCASYAGRKGGCRSYV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Esrrb Original Motif Reverse Complement YDRCCASSVGSKKGCGSKV TGACCTTGMBBB TGACCWYSMGVKKGCGSKV Direction: Forward Position #: 1 Overlap #: 12 Alignment: YDRCCASSVGSKKGCGSKV TGACCTTGMBBB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Reverse Complement Original Motif BRSCGCRYVCYSMWGGTCA VHRGGTCABDBTGMCCTB VDRGSKCABVBTSMHSKBCA Direction: Forward Position #: 2 Overlap #: 17 Alignment: -BRSCGCRYVCYSMWGGTCA VHRGGTCABDBTGMCCTB-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Original Motif Original Motif VDRGSKCABVBTSMHSKBCA TTCAGCACCATGGACAGCKCC VDRGBKCAGBAYCAHGGACAGCKCC Direction: Forward Position #: 5 Overlap #: 16 Alignment: VDRGSKCABVBTSMHSKBCA----- ----TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Reverse Complement GGYGCTGTCCHTGKTBCTGRBCKDV TGRCCTKTGHCCKAB GKBRCYKTYSHYSKHBCTGRBCKDV Direction: Forward Position #: 2 Overlap #: 15 Alignment: GGYGCTGTCCHTGKTBCTGRBCKDV -TGRCCTKTGHCCKAB--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Reverse Complement GKBRCYKTYSHYSKHBCTGRBCKDV TGMYCTTTGBCCK KKVBCTTTBSHCBKHBCTGRBCKDV Direction: Forward Position #: 1 Overlap #: 13 Alignment: GKBRCYKTYSHYSKHBCTGRBCKDV TGMYCTTTGBCCK------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Mycn Original Motif Reverse Complement KKVBCTTTBSHCBKHBCTGRBCKDV GCCACGTGSD KBCHCKTKBVHCBKHBCTGRBCKDV Direction: Forward Position #: 1 Overlap #: 10 Alignment: KKVBCTTTBSHCBKHBCTGRBCKDV GCCACGTGSD--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Reverse Complement KBCHCKTKBVHCBKHBCTGRBCKDV DCCACGTGCV DCCACGTGSVHCBKHBCTGRBCKDV Direction: Forward Position #: 1 Overlap #: 10 Alignment: KBCHCKTKBVHCBKHBCTGRBCKDV DCCACGTGCV--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA Combined Motif Original Motif Reverse Complement DCCACGTGSVHCBKHBCTGRBCKDV GTTGACCTTTGACCTTT DCCACGTGSVHCBKHSYTGACCTTTGACCTTT Direction: Forward Position #: 16 Overlap #: 10 Alignment: DCCACGTGSVHCBKHBCTGRBCKDV------- ---------------GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tcfcp2l1 Combined Motif Reverse Complement Original Motif AAAGGTCAAAGGTCAMSHYBGDVSCACGTGGH CCAGYYHVADCCRG AAAGGTCMMAGBTCAAVCCDGDVSCACGTGGH Direction: Forward Position #: 8 Overlap #: 14 Alignment: AAAGGTCAAAGGTCAMSHYBGDVSCACGTGGH -------CCAGYYHVADCCRG----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 24 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ssCCCCGCSssk ESR1 Reverse Complement Reverse Complement BBSGGCGGGGBS MGGTCAGGGTGACCTRDBHV VBBKGRCSKGGBBMGGTCAG Direction: Backward Position #: 2 Overlap #: 12 Alignment: -------BBSGGCGGGGBS- MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CTCF Original Motif Reverse Complement VBBKGRCSKGGBBMGGTCAG BMSMGCCYMCTKSTGGMHM BVSHGVCBVSKBSWGGYCAG Direction: Forward Position #: 1 Overlap #: 19 Alignment: VBBKGRCSKGGBBMGGTCAG BMSMGCCYMCTKSTGGMHM- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Original Motif BVSHGVCBVSKBSWGGYCAG BTRGGDCARAGGKCA BBVBGVCMVVGGBHRGYCAG Direction: Forward Position #: 1 Overlap #: 15 Alignment: BVSHGVCBVSKBSWGGYCAG BTRGGDCARAGGKCA----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement CTGMCMDBCCBBYGVCBVVB BAGGYCABHBTGACCKHV CTGMCMGBYCHBBGTSMCCBHV Direction: Forward Position #: 5 Overlap #: 16 Alignment: CTGMCMDBCCBBYGVCBVVB-- ----BAGGYCABHBTGACCKHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Reverse Complement Reverse Complement VHBGGYSACVVHGKBCYGYCAG GGYGCTGTCCATGGTGCTGAA VDHGSTSWCCVHGGTBCKBMAG Direction: Forward Position #: 1 Overlap #: 21 Alignment: VHBGGYSACVVHGKBCYGYCAG GGYGCTGTCCATGGTGCTGAA- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Esrrb Original Motif Reverse Complement VDHGSTSWCCVHGGTBCKBMAG TGACCTTGMBBB TGACSYTGHCCVHGGTBCKBMAG Direction: Forward Position #: 2 Overlap #: 11 Alignment: -VDHGSTSWCCVHGGTBCKBMAG TGACCTTGMBBB----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Reverse Complement Reverse Complement CTRBRGBACCHBGGHCAMSGTCA TGMYCTTTGBCCK TGVYVTDKGVCCDBGGHCAMSGTCA Direction: Forward Position #: 3 Overlap #: 11 Alignment: --CTRBRGBACCHBGGHCAMSGTCA TGMYCTTTGBCCK------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Tcfcp2l1 Original Motif Original Motif TGVYVTDKGVCCDBGGHCAMSGTCA CCAGYYHVADCCRG YSVGHTHDVDCCDGGGHCAMSGTCA Direction: Forward Position #: 1 Overlap #: 14 Alignment: TGVYVTDKGVCCDBGGHCAMSGTCA CCAGYYHVADCCRG----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Mycn Original Motif Reverse Complement YSVGHTHDVDCCDGGGHCAMSGTCA GCCACGTGSD GCCACGTGBVDCCDGGGHCAMSGTCA Direction: Forward Position #: 2 Overlap #: 9 Alignment: -YSVGHTHDVDCCDGGGHCAMSGTCA GCCACGTGSD---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Reverse Complement GCCACGTGBVDCCDGGGHCAMSGTCA DCCACGTGCV GCCACGTGVVDCCDGGGHCAMSGTCA Direction: Forward Position #: 1 Overlap #: 10 Alignment: GCCACGTGBVDCCDGGGHCAMSGTCA DCCACGTGCV---------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 29 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- cCGCGGrCACG REST Original Motif Original Motif CCGCGGRCACG TTCAGCACCATGGACAGCKCC KCCCCRCGGACASSTTCAGCA Direction: Backward Position #: 4 Overlap #: 11 Alignment: -------CCGCGGRCACG--- TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Reverse Complement Reverse Complement TGCTGAASSTGTCCGMGGGGY MGGTCAGGGTGACCTRDBHV WGSTSAVVSTGDCCKVGGBVY Direction: Forward Position #: 1 Overlap #: 20 Alignment: TGCTGAASSTGTCCGMGGGGY MGGTCAGGGTGACCTRDBHV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CTCF Combined Motif Original Motif Reverse Complement WGSTSAVVSTGDCCKVGGBVY BMSMGCCYMCTKSTGGMHM WGSTBAVVGYSHCCTDGKGGHHM Direction: Forward Position #: 5 Overlap #: 17 Alignment: WGSTSAVVSTGDCCKVGGBVY-- ----BMSMGCCYMCTKSTGGMHM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Original Motif YDDCCRCHAGGHSMCVVTBASCW BTRGGDCARAGGKCA BBRSSDCAARGDBCMVVTBASCW Direction: Forward Position #: 1 Overlap #: 15 Alignment: YDDCCRCHAGGHSMCVVTBASCW BTRGGDCARAGGKCA-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Reverse Complement Reverse Complement WGSTBAVVYGBHCMTTGHSSMVB BAGGYCABHBTGACCKHV WGSTBAGVYVHHCVTKRCCBHVB Direction: Forward Position #: 5 Overlap #: 18 Alignment: WGSTBAVVYGBHCMTTGHSSMVB ----BAGGYCABHBTGACCKHV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Myc Combined Motif Original Motif Original Motif WGSTBAGVYVHHCVTKRCCBHVB VGCACGTGGH WGSBCASGTGVHCVTKRCCBHVB Direction: Forward Position #: 3 Overlap #: 10 Alignment: WGSTBAGVYVHHCVTKRCCBHVB --VGCACGTGGH----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn Combined Motif Original Motif Original Motif WGSBCASGTGVHCVTKRCCBHVB HSCACGTGGC WGVBCACGTGGCCVTKRCCBHVB Direction: Forward Position #: 3 Overlap #: 10 Alignment: WGSBCASGTGVHCVTKRCCBHVB --HSCACGTGGC----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MIZF Combined Motif Original Motif Reverse Complement WGVBCACGTGGCCVTKRCCBHVB GCGGACGTTV WGCGSACGTDVCCVTKRCCBHVB Direction: Forward Position #: 2 Overlap #: 10 Alignment: WGVBCACGTGGCCVTKRCCBHVB -GCGGACGTTV------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Esrrb Original Motif Original Motif WGCGSACGTDVCCVTKRCCBHVB VBBYCAAGGTCA HGCBSAMGKTCACVTKRCCBHVB Direction: Forward Position #: 1 Overlap #: 12 Alignment: WGCGSACGTDVCCVTKRCCBHVB VBBYCAAGGTCA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Reverse Complement HGCBSAMGKTCACVTKRCCBHVB TGMYCTTTGBCCK HGBGVMCKKTSVCCTKRCCBHVB Direction: Forward Position #: 3 Overlap #: 13 Alignment: HGCBSAMGKTCACVTKRCCBHVB --TGMYCTTTGBCCK-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 4 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Esrrb TgTGgTGTCACAGTGCTCC Reverse Complement Original Motif TGACCTTGMBBB TGTGGTGTCACAGTGCTCC TSACMKTGCTCCTGTGGTG Direction: Backward Position #: 1 Overlap #: 12 Alignment: -------TGACCTTGMBBB TGTGGTGTCACAGTGCTCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TGGAGCACTGTGACAcCACAGTGg Combined Motif Original Motif Reverse Complement TSACMKTGCTCCTGTGGTG CCACTGTGVTGTCACAGTGCTCCA YCACTGTGVTSTYRYRGTGCTCCA Direction: Forward Position #: 1 Overlap #: 19 Alignment: TSACMKTGCTCCTGTGGTG----- CCACTGTGVTGTCACAGTGCTCCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CACTGTGrYrtCACAGTGswsCAcT Reverse Complement Reverse Complement TGGAGCACKKKKASAVCACAGTGM AGTGSWSCACTGTGAMAMCACAGTG AGTGGAGCACTGTGACAVCACAGTGM Direction: Forward Position #: 3 Overlap #: 23 Alignment: --TGGAGCACKKKKASAVCACAGTGM AGTGSWSCACTGTGAMAMCACAGTG- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif wwCCAmAGTCmt Reverse Complement Reverse Complement YCACTGTGVTGTCACAGTGCTCCACT VDGACTRTGGDD VBSACTGTGGTDTCACAGTGCTCCACT Direction: Forward Position #: 2 Overlap #: 11 Alignment: -YCACTGTGVTGTCACAGTGCTCCACT VDGACTRTGGDD--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ssGCkTGCssk Combined Motif Original Motif Original Motif VBSACTGTGGTDTCACAGTGCTCCACT SSGCKTGCSSK VBSACTGTGGTDTCACAGTGCTSCRCTTGCSSK Direction: Forward Position #: 23 Overlap #: 5 Alignment: VBSACTGTGGTDTCACAGTGCTCCACT------ ----------------------SSGCKTGCSSK ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ssCCCCGCSssk Original Motif Reverse Complement VBSACTGTGGTDTCACAGTGCTSCRCTTGCSSK BBSGGCGGGGBS BBSRSYGKGGBBTCACAGTGCTSCRCTTGCSSK Direction: Forward Position #: 1 Overlap #: 12 Alignment: VBSACTGTGGTDTCACAGTGCTSCRCTTGCSSK BBSGGCGGGGBS--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AgTGCTCCACTGTGgTGTCACAgT Original Motif Original Motif BBSRSYGKGGBBTCACAGTGCTSCRCTTGCSSK AGTGCTCCACTGTGGTGTCACAGT AGTGCTCCACTGTGGTGTCACAGTGCTSCRCTTGCSSK Direction: Forward Position #: 6 Overlap #: 19 Alignment: -----BBSRSYGKGGBBTCACAGTGCTSCRCTTGCSSK AGTGCTCCACTGTGGTGTCACAGT-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif atactttggc Original Motif Reverse Complement AGTGCTCCACTGTGGTGTCACAGTGCTSCRCTTGCSSK GCCAAAGTAT AGTATSSCWWAGTGCTCCACTGTGGTGTCACAGTGCTSCRCTT Direction: Backward Position #: 6 Overlap #: 5 Alignment: AGTGCTCCACTGTGGTGTCACAGTGCTSCRCTTGCSSK----- ---------------------------------GCCAAAGTAT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif cCGCGGrCACG Original Motif Original Motif AGTATSSCWWAGTGCTCCACTGTGGTGTCACAGTGCTSCRCTT CCGCGGRCACG RCACGSYGCKSAGTATSSCWWAGTGCTCCACTGTGGTGTCACAGTGCT Direction: Backward Position #: 6 Overlap #: 6 Alignment: AGTATSSCWWAGTGCTCCACTGTGGTGTCACAGTGCTSCRCTT----- -------------------------------------CCGCGGRCACG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AmTGTGACACCACAGT Reverse Complement Reverse Complement AGCACTGTGACACCACAGTGGAGCACTWWGSSATACTSYGCMSCGTGK ACTGTGGTGTCACART ACWGYRSTGTSACAVYACAGTGGAGCACTWWGSSATACTSYGCMSCGTGK Direction: Forward Position #: 3 Overlap #: 14 Alignment: --AGCACTGTGACACCACAGTGGAGCACTWWGSSATACTSYGCMSCGTGK ACTGTGGTGTCACART---------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ************************************************************ Combined Motifs for Top Global Significant Motif ID 13 and Its Best Matches *********************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MIZF gCGCGCsCgsG Original Motif Original Motif BAACGTCCGC GCGCGCSCGCG BHRCGYCCGCG Direction: Forward Position #: 1 Overlap #: 10 Alignment: BAACGTCCGC- GCGCGCSCGCG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Results created by MOTIFSIM on 06-18-2018 13:12:37 Runtime: 641.554 seconds MOTIFSIM is written by Ngoc Tam L. 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