**************************************************************************************************************************************************************************************************** MOTIFSIM - Motif Similarity Detection Tool Version 2.2 **************************************************************************************************************************************************************************************************** INPUT **************************************************************************************************************************************************************************************************** Input Parameters Number of files: 2 Number of top significant motifs: 10 Number of best matches: 10 Similarity cutoff: >= 0.75 Matching motif database: UniProbe Mus Musculus Motif tree: Yes Combined similar motifs: Yes Output file type: All Output file format: All Input files and motif counts File name Count of motifs Dataset # PScanChIP_DM05.txt 16 1 RSAT_peak-motifs_DM05.txt 17 2 **************************************************************************************************************************************************************************************************** RESULTS **************************************************************************************************************************************************************************************************** ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 5 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZEB1 CTCF Reverse Complement Original Motif HAGGTG YDRCCASYAGRKGGCRSYV YDRCCASYAGGTGGCRSYV Direction: Forward Position #: 8 Overlap #: 6 Alignment: -------HAGGTG------ YDRCCASYAGRKGGCRSYV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RORA_1 Combined Motif Original Motif Reverse Complement YDRCCASYAGGTGGCRSYV TGACCTDVWT YDRCCASYAGGTGRCSBHVWT Direction: Forward Position #: 12 Overlap #: 8 Alignment: YDRCCASYAGGTGGCRSYV-- -----------TGACCTDVWT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif YDRCCASYAGGTGRCSBHVWT TTCAGCACCATGGACAGCKCC TTCAGCACCAYGGMCAGCASSTGRCSBHVWT Direction: Forward Position #: 11 Overlap #: 11 Alignment: ----------YDRCCASYAGGTGRCSBHVWT TTCAGCACCATGGACAGCKCC---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Esrrb Reverse Complement Original Motif AWVHVSGKCASSTGCTGRCCMTGGTGCTGAA VBBYCAAGGTCA VBDTCAAGGTCASSTGCTGRCCMTGGTGCTGAA Direction: Forward Position #: 3 Overlap #: 10 Alignment: --AWVHVSGKCASSTGCTGRCCMTGGTGCTGAA VBBYCAAGGTCA--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Original Motif Original Motif VBDTCAAGGTCASSTGCTGRCCMTGGTGCTGAA AAAGGTCAAAGGTCAAC AAAGGTCAAAGGTCAVCTGCTGRCCMTGGTGCTGAA Direction: Forward Position #: 4 Overlap #: 14 Alignment: ---VBDTCAAGGTCASSTGCTGRCCMTGGTGCTGAA AAAGGTCAAAGGTCAAC------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Original Motif AAAGGTCAAAGGTCAVCTGCTGRCCMTGGTGCTGAA BTRGGDCARAGGKCA VDRGGDCAAAGGTCAVCTGCTGRCCMTGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 15 Alignment: AAAGGTCAAAGGTCAVCTGCTGRCCMTGGTGCTGAA BTRGGDCARAGGKCA--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR4A2 Combined Motif Original Motif Original Motif VDRGGDCAAAGGTCAVCTGCTGRCCMTGGTGCTGAA AAGGTCAC VAAGGTCAMAGGTCAVCTGCTGRCCMTGGTGCTGAA Direction: Forward Position #: 2 Overlap #: 8 Alignment: VDRGGDCAAAGGTCAVCTGCTGRCCMTGGTGCTGAA -AAGGTCAC--------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Original Motif VAAGGTCAMAGGTCAVCTGCTGRCCMTGGTGCTGAA VDBHMAGGTCACCCTGACCY VDBHHAGGTCAVMSKKMMMYTGCTGRCCMTGGTGCTGAA Direction: Forward Position #: 4 Overlap #: 17 Alignment: ---VAAGGTCAMAGGTCAVCTGCTGRCCMTGGTGCTGAA VDBHMAGGTCACCCTGACCY------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Mycn Original Motif Original Motif VDBHHAGGTCAVMSKKMMMYTGCTGRCCMTGGTGCTGAA HSCACGTGGC VBCACRKGKCAVMSKKMMMYTGCTGRCCMTGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 10 Alignment: VDBHHAGGTCAVMSKKMMMYTGCTGRCCMTGGTGCTGAA HSCACGTGGC----------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Myc Original Motif Original Motif VBCACRKGKCAVMSKKMMMYTGCTGRCCMTGGTGCTGAA VGCACGTGGH VVCACGTGGCAVMSKKMMMYTGCTGRCCMTGGTGCTGAA Direction: Forward Position #: 1 Overlap #: 10 Alignment: VBCACRKGKCAVMSKKMMMYTGCTGRCCMTGGTGCTGAA VGCACGTGGH----------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 28 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ssGCkTGCssk gCGCGCsCgsG Original Motif Original Motif SSGCKTGCSSK GCGCGCSCGCG SCGCGYGCSSG Direction: Backward Position #: 1 Overlap #: 11 Alignment: SSGCKTGCSSK GCGCGCSCGCG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ssCCCCGCSssk Combined Motif Reverse Complement Original Motif CSSGCKCGCGS SBCCCCGCCSBB CSSSCBCGCSSBB Direction: Forward Position #: 2 Overlap #: 10 Alignment: CSSGCKCGCGS-- -SBCCCCGCCSBB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif sscCCCGCGcs Reverse Complement Original Motif BBSSGCGBGSSSG BSCCCCGCGBS BBSCSCGCGSSSG Direction: Forward Position #: 1 Overlap #: 11 Alignment: BBSSGCGBGSSSG BSCCCCGCGBS-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif cCGCGGrCACG Reverse Complement Reverse Complement CSSSCGCGSGSBB CGTGKCCGCGG CGBGYSCGCGSBB Direction: Forward Position #: 1 Overlap #: 11 Alignment: CSSSCGCGSGSBB CGTGKCCGCGG-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CTCF Reverse Complement Reverse Complement BBSCGCGSKCVCG BMSMGCCYMCTKSTGGMHM BVSCGCSSVCDBGTGGMHM Direction: Forward Position #: 1 Overlap #: 13 Alignment: BBSCGCGSKCVCG------ BMSMGCCYMCTKSTGGMHM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif Esrrb Reverse Complement Reverse Complement YDRCCACBDGVSSGCGSVV TGACCTTGMBBB TGACCWYSHGBBSGCGSVV Direction: Forward Position #: 1 Overlap #: 12 Alignment: YDRCCACBDGVSSGCGSVV TGACCTTGMBBB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Reverse Complement Reverse Complement BVSCGCSBBCHSMWGGTCA BAGGYCABHBTGACCKHV BMGVBCVBBBTGAHSGTVA Direction: Forward Position #: 1 Overlap #: 18 Alignment: BVSCGCSBBCHSMWGGTCA BAGGYCABHBTGACCKHV- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Original Motif Original Motif BMGVBCVBBBTGAHSGTVA TTCAGCACCATGGACAGCKCC BMGBBCAGBAYSAHGGWCAGCKCC Direction: Forward Position #: 4 Overlap #: 16 Alignment: BMGVBCVBBBTGAHSGTVA----- ---TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Reverse Complement GGYGCTGWCCHTSKTBCTGVBCYB TGRCCTKTGHCCKAB KGHSCTKTSCCYGDBBCTGVBCYB Direction: Forward Position #: 1 Overlap #: 15 Alignment: GGYGCTGWCCHTSKTBCTGVBCYB TGRCCTKTGHCCKAB--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Reverse Complement KGHSCTKTSCCYGDBBCTGVBCYB TGMYCTTTGBCCK TKVHCYTTKBCCBGDBBCTGVBCYB Direction: Forward Position #: 2 Overlap #: 12 Alignment: -KGHSCTKTSCCYGDBBCTGVBCYB TGMYCTTTGBCCK------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 25 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- wwCCAmAGTCmt CACTGTGrYrtCACAGTGswsCAcT Original Motif Original Motif DDCCAMAGTCHB CACTGTGRTRTCACAGTGSWSCACT CACTGTGRHDYCACAGTSBWSCACT Direction: Forward Position #: 9 Overlap #: 12 Alignment: --------DDCCAMAGTCHB----- CACTGTGRTRTCACAGTGSWSCACT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CagTGCTCCACTGTGgT Reverse Complement Original Motif AGTGSWBSACTGTGKHHMCACAGTG CAGTGCTCCACTGTGBT CAGTGCTCCACTGTGKHHMCACAGTG Direction: Forward Position #: 2 Overlap #: 16 Alignment: -AGTGSWBSACTGTGKHHMCACAGTG CAGTGCTCCACTGTGBT--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CAcCACAGTGGAGCAct Reverse Complement Original Motif CACTGTGRHHYCACAGTGGAGCACTG CAHCACAGTGGAGCACT CAHCACWGTGGAVCMMYAGTGGAGCACTG Direction: Forward Position #: 4 Overlap #: 14 Alignment: ---CACTGTGRHHYCACAGTGGAGCACTG CAHCACAGTGGAGCACT------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AgTGCTCCACTGTGgTGTCACAgT Original Motif Original Motif CAHCACWGTGGAVCMMYAGTGGAGCACTG AGTGCTCCACTGTGGTGTCACAGT AGTGCWCCACTGTGGTGYCACAGTGGAGCACTG Direction: Forward Position #: 5 Overlap #: 20 Alignment: ----CAHCACWGTGGAVCMMYAGTGGAGCACTG AGTGCTCCACTGTGGTGTCACAGT--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Original Motif AGTGCWCCACTGTGGTGYCACAGTGGAGCACTG RGGBCAAAGKYCA AGTGSDCCAMWGTGSWGYCACAGTGGAGCACTG Direction: Forward Position #: 4 Overlap #: 13 Alignment: AGTGCWCCACTGTGGTGYCACAGTGGAGCACTG ---RGGBCAAAGKYCA----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TGGAGCACTGTGACAcCACAGTGg Original Motif Reverse Complement AGTGSDCCAMWGTGSWGYCACAGTGGAGCACTG CCACTGTGVTGTCACAGTGCTCCA CCACTRKKGTGTCACAGTGCTSYMACAGTGGAGCACTG Direction: Forward Position #: 6 Overlap #: 19 Alignment: -----AGTGSDCCAMWGTGSWGYCACAGTGGAGCACTG CCACTGTGVTGTCACAGTGCTCCA-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Reverse Complement Original Motif CAGTGCTCCACTGTYKSAGCACTGTGACACRRMAGTGG TTCAGCACCATGGACAGCKCC TGGTKCAGCACYRTGRMMAGVVMSCAGTGCTCCACTGT Direction: Backward Position #: 4 Overlap #: 21 Alignment: CAGTGCTCCACTGTYKSAGCACTGTGACACRRMAGTGG --------------TTCAGCACCATGGACAGCKCC--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TgTGgTGTCACAGTGCTCC Original Motif Original Motif TGGTKCAGCACYRTGRMMAGVVMSCAGTGCTCCACTGT TGTGGTGTCACAGTGCTCC TGKKKYRKCACHGTGVWCMGVVMSCAGTGCTCCACTGT Direction: Forward Position #: 1 Overlap #: 19 Alignment: TGGTKCAGCACYRTGRMMAGVVMSCAGTGCTCCACTGT TGTGGTGTCACAGTGCTCC------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Original Motif Original Motif TGKKKYRKCACHGTGVWCMGVVMSCAGTGCTCCACTGT VDBHMAGGTCACCCTGACCY TGKKKYVDCACAGKKCWCCVHGACCHGTGCTCCACTGT Direction: Forward Position #: 7 Overlap #: 20 Alignment: TGKKKYRKCACHGTGVWCMGVVMSCAGTGCTCCACTGT ------VDBHMAGGTCACCCTGACCY------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 19 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- atactttggc wwCCAmAGTCmt Reverse Complement Original Motif GCCAAAGTAT DDCCAMAGTCHB BGCCAAAGTMTD Direction: Backward Position #: 2 Overlap #: 10 Alignment: -GCCAAAGTAT- DDCCAMAGTCHB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif taaacgatgcc Reverse Complement Original Motif DAYACTTTGGCV TAAACGATGCC TAWACKWTGSCV Direction: Forward Position #: 1 Overlap #: 11 Alignment: DAYACTTTGGCV TAAACGATGCC- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Original Motif Reverse Complement TAWACKWTGSCV GTTGACCTTTGACCTTT GTTRAMCTTTGVCCTTT Direction: Forward Position #: 3 Overlap #: 12 Alignment: --TAWACKWTGSCV--- GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TgTGgTGTCACAGTGCTCC Original Motif Reverse Complement GTTRAMCTTTGVCCTTT GGAGCACTGTGACACCACA GKWGMACTKTGACMYYWCA Direction: Forward Position #: 1 Overlap #: 17 Alignment: GTTRAMCTTTGVCCTTT-- GGAGCACTGTGACACCACA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CACTGTGrYrtCACAGTGswsCAcT Original Motif Reverse Complement GKWGMACTKTGACMYYWCA AGTGSWSCACTGTGAMAMCACAGTG AGTDGHVCWBTGWSAHHHCACAGTG Direction: Forward Position #: 2 Overlap #: 19 Alignment: -GKWGMACTKTGACMYYWCA----- AGTGSWSCACTGTGAMAMCACAGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Original Motif Reverse Complement AGTDGHVCWBTGWSAHHHCACAGTG TGMYCTTTGBCCK AGTDGHGCHCTKTGVCCDCACAGTG Direction: Forward Position #: 6 Overlap #: 13 Alignment: AGTDGHVCWBTGWSAHHHCACAGTG -----TGMYCTTTGBCCK------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Original Motif CACTGTGDGGBCAYAGHGCHCHACT TGAMCTTTGMMCYT TGMACTKTGVVBHBAYAGHGCHCHACT Direction: Forward Position #: 3 Overlap #: 12 Alignment: --CACTGTGDGGBCAYAGHGCHCHACT TGAMCTTTGMMCYT------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TGGAGCACTGTGACAcCACAGTGg Original Motif Original Motif TGMACTKTGVVBHBAYAGHGCHCHACT TGGAGCACTGTGACAVCACAGTGG TGGWGMACTGTGACAHCACAGTGVHCHACT Direction: Forward Position #: 4 Overlap #: 21 Alignment: ---TGMACTKTGVVBHBAYAGHGCHCHACT TGGAGCACTGTGACAVCACAGTGG------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AgTGCTCCACTGTGgTGTCACAgT Reverse Complement Original Motif AGTDGHVCACTGTGDTGTCACAGTRCWCCA AGTGCTCCACTGTGGTGTCACAGT AGTGSTCCACTGTGGTGTCACAGTRCWCCA Direction: Forward Position #: 1 Overlap #: 24 Alignment: AGTDGHVCACTGTGDTGTCACAGTRCWCCA AGTGCTCCACTGTGGTGTCACAGT------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CAcCACAGTGGAGCAct Original Motif Reverse Complement AGTGSTCCACTGTGGTGTCACAGTRCWCCA AGTGCTCCACTGTGDTG AGTGCTCCACTGTGGTGTCACAGTRCWCCA Direction: Forward Position #: 1 Overlap #: 17 Alignment: AGTGSTCCACTGTGGTGTCACAGTRCWCCA AGTGCTCCACTGTGDTG------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 11 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR4A2 NR1H2RXRA Original Motif Original Motif AAGGTCAC AAAGGTCAAAGGTCAAC AGGTCAACAAGGTCAMA Direction: Backward Position #: 9 Overlap #: 8 Alignment: -AAGGTCAC-------- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Reverse Complement AGGTCAACAAGGTCAMA MGGTCAGGGTGACCTRDBHV AGGTCARSRWGRYCWVVBHV Direction: Forward Position #: 1 Overlap #: 17 Alignment: AGGTCAACAAGGTCAMA--- MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Original Motif Reverse Complement AGGTCARSRWGRYCWVVBHV BAGGYCABHBTGACCKHV BAGGTCAVBVTGRCCDDVBHV Direction: Forward Position #: 2 Overlap #: 17 Alignment: -AGGTCARSRWGRYCWVVBHV BAGGYCABHBTGACCKHV--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Reverse Complement VDBVDDGGKCAVBBTGACCTB TGRCCTKTGHCCKAB TVVCCTDKGBCMBVBTGACCTB Direction: Forward Position #: 2 Overlap #: 14 Alignment: -VDBVDDGGKCAVBBTGACCTB TGRCCTKTGHCCKAB------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CACTGTGrYrtCACAGTGswsCAcT Combined Motif Original Motif Reverse Complement TVVCCTDKGBCMBVBTGACCTB AGTGSWSCACTGTGAMAMCACAGTG TVVMVTGKDBCACTGTGACMHCACAGTG Direction: Forward Position #: 4 Overlap #: 19 Alignment: TVVCCTDKGBCMBVBTGACCTB------ ---AGTGSWSCACTGTGAMAMCACAGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Original Motif Original Motif TVVMVTGKDBCACTGTGACMHCACAGTG TGAMCTTTGMMCYT TGAMCTKTGVCMHTGTGACMHCACAGTG Direction: Forward Position #: 1 Overlap #: 14 Alignment: TVVMVTGKDBCACTGTGACMHCACAGTG TGAMCTTTGMMCYT-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Reverse Complement Reverse Complement CACTGTGHRGTCACADRGVCARAGYTCA GGYGCTGTCCATGGTGCTGAA CACKGTGCKGTCMHHGGKVCWRARYTCA Direction: Forward Position #: 4 Overlap #: 21 Alignment: CACTGTGHRGTCACADRGVCARAGYTCA ---GGYGCTGTCCATGGTGCTGAA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TGGAGCACTGTGACAcCACAGTGg Original Motif Reverse Complement CACKGTGCKGTCMHHGGKVCWRARYTCA CCACTGTGVTGTCACAGTGCTCCA CCACTGTGVTGTCACAGKKSYHVARYTCA Direction: Forward Position #: 2 Overlap #: 23 Alignment: -CACKGTGCKGTCMHHGGKVCWRARYTCA CCACTGTGVTGTCACAGTGCTCCA----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AmTGTGACACCACAGT Reverse Complement Reverse Complement TGAMMTVDMSYRCTGTGACAVCACAGTGG ACTGTGGTGTCACART ACTGWVVTGTCACAVTGTGACAVCACAGTGG Direction: Forward Position #: 3 Overlap #: 14 Alignment: --TGAMMTVDMSYRCTGTGACAVCACAGTGG ACTGTGGTGTCACART--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TgTGgTGTCACAGTGCTCC Reverse Complement Reverse Complement CCACTGTGVTGTCACAVTGTGACAVVWCAGT GGAGCACTGTGACACCACA GGASCACTGTGAYRYCACAVTGTGACAVVWCAGT Direction: Forward Position #: 4 Overlap #: 16 Alignment: ---CCACTGTGVTGTCACAVTGTGACAVVWCAGT GGAGCACTGTGACACCACA--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 4 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Esrrb NR2F1 Reverse Complement Original Motif TGACCTTGMBBB TGAMCTTTGMMCYT WSMYYTKRMCHBTG Direction: Backward Position #: 1 Overlap #: 12 Alignment: --TGACCTTGMBBB TGAMCTTTGMMCYT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PPARGRXRA Combined Motif Reverse Complement Original Motif CAVDGYMYAKKRSW BTRGGDCARAGGKCA CVHRGBVCADRGGTCA Direction: Forward Position #: 2 Overlap #: 13 Alignment: CAVDGYMYAKKRSW-- -BTRGGDCARAGGKCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Reverse Complement Reverse Complement TGACCKHTGVBCMHBG TGMYCTTTGBCCK TGVCCTTTGBHCBHBG Direction: Forward Position #: 1 Overlap #: 13 Alignment: TGACCKHTGVBCMHBG TGMYCTTTGBCCK--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Original Motif Reverse Complement TGVCCTTTGBHCBHBG GTTGACCTTTGACCTTT GTTGACCTTTGACCTDTG Direction: Forward Position #: 3 Overlap #: 15 Alignment: --TGVCCTTTGBHCBHBG GTTGACCTTTGACCTTT- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Reverse Complement GTTGACCTTTGACCTDTG MGGTCAGGGTGACCTRDBHV VKKKMMSKBTGACCTDBGHV Direction: Forward Position #: 1 Overlap #: 18 Alignment: GTTGACCTTTGACCTDTG-- MGGTCAGGGTGACCTRDBHV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Original Motif Reverse Complement VKKKMMSKBTGACCTDBGHV BAGGYCABHBTGACCKHV VDGGHMMBBTKRMCYKDGHV Direction: Forward Position #: 1 Overlap #: 18 Alignment: VKKKMMSKBTGACCTDBGHV BAGGYCABHBTGACCKHV-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif VDGGHMMBBTKRMCYKDGHV TTCAGCACCATGGACAGCKCC TBHRGHACCHTGGACAGHDVC Direction: Forward Position #: 2 Overlap #: 20 Alignment: -VDGGHMMBBTKRMCYKDGHV TTCAGCACCATGGACAGCKCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TgTGgTGTCACAGTGCTCC Combined Motif Reverse Complement Original Motif GVHDCTGTCCAHGGTDCKDVA TGTGGTGTCACAGTGCTCC GVHDCTGTCCAHKGTGSTGTMACAGTGCTCC Direction: Forward Position #: 13 Overlap #: 9 Alignment: GVHDCTGTCCAHGGTDCKDVA---------- ------------TGTGGTGTCACAGTGCTCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TGGAGCACTGTGACAcCACAGTGg Reverse Complement Original Motif GGAGCACTGTRACASCACRHTGGACAGHDVC TGGAGCACTGTGACAVCACAGTGG TGGAGCACTGTGACASCACADTGGACAGHDVC Direction: Forward Position #: 2 Overlap #: 23 Alignment: -GGAGCACTGTRACASCACRHTGGACAGHDVC TGGAGCACTGTGACAVCACAGTGG-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CACTGTGrYrtCACAGTGswsCAcT Original Motif Reverse Complement TGGAGCACTGTGACASCACADTGGACAGHDVC AGTGSWSCACTGTGAMAMCACAGTG AGTGGAGCACTGTGACAVCACAGTGGACAGHDVC Direction: Forward Position #: 3 Overlap #: 23 Alignment: --TGGAGCACTGTGACASCACADTGGACAGHDVC AGTGSWSCACTGTGAMAMCACAGTG--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 1 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A PPARGRXRA Original Motif Original Motif RGGBCAAAGKYCA BTRGGDCARAGGKCA BTRGGBCAAAGGTCA Direction: Forward Position #: 3 Overlap #: 13 Alignment: --RGGBCAAAGKYCA BTRGGDCARAGGKCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR2F1 Reverse Complement Original Motif TGACCTTTGBCCKAB TGAMCTTTGMMCYT TGACCTTTGVMCBHB Direction: Forward Position #: 1 Overlap #: 14 Alignment: TGACCTTTGBCCKAB TGAMCTTTGMMCYT- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif NR1H2RXRA Reverse Complement Original Motif BHVGRVCAAAGGTCA AAAGGTCAAAGGTCAAC VAAGGTCAAAGGTCAAC Direction: Forward Position #: 1 Overlap #: 15 Alignment: BHVGRVCAAAGGTCA-- AAAGGTCAAAGGTCAAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CACTGTGrYrtCACAGTGswsCAcT Reverse Complement Reverse Complement GTTGACCTTTGACCTTB AGTGSWSCACTGTGAMAMCACAGTG AGTGBTGMMCTKTGACMHYACAGTG Direction: Forward Position #: 4 Overlap #: 17 Alignment: ---GTTGACCTTTGACCTTB----- AGTGSWSCACTGTGAMAMCACAGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TGGAGCACTGTGACAcCACAGTGg Combined Motif Original Motif Original Motif AGTGBTGMMCTKTGACMHYACAGTG TGGAGCACTGTGACAVCACAGTGG AGTGGWGCACTGTGACAHCACAGTGG Direction: Forward Position #: 3 Overlap #: 23 Alignment: AGTGBTGMMCTKTGACMHYACAGTG- --TGGAGCACTGTGACAVCACAGTGG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR2 Combined Motif Original Motif Reverse Complement AGTGGWGCACTGTGACAHCACAGTGG BAGGYCABHBTGACCKHV AGTRGDBCACTGTGACMBHDCAGTGG Direction: Forward Position #: 3 Overlap #: 18 Alignment: AGTGGWGCACTGTGACAHCACAGTGG --BAGGYCABHBTGACCKHV------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TgTGgTGTCACAGTGCTCC Original Motif Original Motif AGTRGDBCACTGTGACMBHDCAGTGG TGTGGTGTCACAGTGCTCC TRKKGKGTCACWGTGMYCCHDCAGTGG Direction: Forward Position #: 2 Overlap #: 18 Alignment: -AGTRGDBCACTGTGACMBHDCAGTGG TGTGGTGTCACAGTGCTCC-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Original Motif TRKKGKGTCACWGTGMYCCHDCAGTGG VDBHMAGGTCACCCTGACCY VDVBBRKGTCACHSTGMCCYHDCAGTGG Direction: Forward Position #: 2 Overlap #: 19 Alignment: -TRKKGKGTCACWGTGMYCCHDCAGTGG VDBHMAGGTCACCCTGACCY-------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- REST Combined Motif Original Motif Reverse Complement VDVBBRKGTCACHSTGMCCYHDCAGTGG GGYGCTGTCCATGGTGCTGAA VKVHBCTGTCMMHGKKVCYBHACAGTGG Direction: Forward Position #: 2 Overlap #: 21 Alignment: VDVBBRKGTCACHSTGMCCYHDCAGTGG -GGYGCTGTCCATGGTGCTGAA------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- AgTGCTCCACTGTGgTGTCACAgT Combined Motif Original Motif Original Motif VKVHBCTGTCMMHGKKVCYBHACAGTGG AGTGCTCCACTGTGGTGTCACAGT VKVHBCTGTCMMHVGTGCTCCACWGTGGTGTCACAGT Direction: Forward Position #: 14 Overlap #: 15 Alignment: VKVHBCTGTCMMHGKKVCYBHACAGTGG--------- -------------AGTGCTCCACTGTGGTGTCACAGT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CTCF Combined Motif Reverse Complement Original Motif ACTGTGACACCACWGTGGAGCACBHRRGACAGBDVYV YDRCCASYAGRKGGCRSYV ACTGTGACACCACHRKGGRGCRCBVRRGACAGBDVYV Direction: Forward Position #: 7 Overlap #: 19 Alignment: ACTGTGACACCACWGTGGAGCACBHRRGACAGBDVYV ------YDRCCASYAGRKGGCRSYV------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 12 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RORA_1 Esrrb Original Motif Original Motif AWVDAGGTCA VBBYCAAGGTCA DTCAAGGTCAVB Direction: Backward Position #: 1 Overlap #: 10 Alignment: --AWVDAGGTCA VBBYCAAGGTCA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Original Motif DTCAAGGTCAVB VDBHMAGGTCACCCTGACCY VDBCHAGGTCAVBCTGACCY Direction: Forward Position #: 2 Overlap #: 12 Alignment: -DTCAAGGTCAVB------- VDBHMAGGTCACCCTGACCY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR1H2RXRA Combined Motif Original Motif Reverse Complement VDBCHAGGTCAVBCTGACCY GTTGACCTTTGACCTTT VDBCHAGGTCAVBYTGACCTTTGACCTTT Direction: Forward Position #: 13 Overlap #: 8 Alignment: VDBCHAGGTCAVBCTGACCY--------- ------------GTTGACCTTTGACCTTT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- NR2F1 Combined Motif Reverse Complement Reverse Complement AAAGGTCAAAGGTCAMBVTGACCTHGVDV AKGYYCAAAGRTCA AARGGTCAAAGGTCAMBVTGACCTHGVDV Direction: Forward Position #: 2 Overlap #: 14 Alignment: AAAGGTCAAAGGTCAMBVTGACCTHGVDV -AKGYYCAAAGRTCA-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Original Motif Original Motif AARGGTCAAAGGTCAMBVTGACCTHGVDV BTRGGDCARAGGKCA VDRGGKCAAAGGTCAMBVTGACCTHGVDV Direction: Forward Position #: 1 Overlap #: 15 Alignment: AARGGTCAAAGGTCAMBVTGACCTHGVDV BTRGGDCARAGGKCA-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif REST Original Motif Original Motif VDRGGKCAAAGGTCAMBVTGACCTHGVDV TTCAGCACCATGGACAGCKCC THCAGSACMAHGGWCAGCDYSACCTHGVDV Direction: Forward Position #: 2 Overlap #: 20 Alignment: -VDRGGKCAAAGGTCAMBVTGACCTHGVDV TTCAGCACCATGGACAGCKCC--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HNF4A Combined Motif Reverse Complement Original Motif VDBCHAGGTSMHGCTGWCCHTYGTSCTGHA RGGBCAAAGKYCA VDBCHAGGKBMARMKGHCMHTYGTSCTGHA Direction: Forward Position #: 7 Overlap #: 13 Alignment: VDBCHAGGTSMHGCTGWCCHTYGTSCTGHA ------RGGBCAAAGKYCA----------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TgTGgTGTCACAGTGCTCC Original Motif Original Motif VDBCHAGGKBMARMKGHCMHTYGTSCTGHA TGTGGTGTCACAGTGCTCC ACAGTGCTCCWRHGGTSYCVDBCHAGGKBMARMKGHCMHT Direction: Backward Position #: 11 Overlap #: 9 Alignment: VDBCHAGGKBMARMKGHCMHTYGTSCTGHA---------- ---------------------TGTGGTGTCACAGTGCTCC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- wwCCAmAGTCmt Combined Motif Reverse Complement Reverse Complement AHRGHCRYKTRBRCCTHGVDVGMSACCHMWGGAGCACTGT VDGACTRTGGDD AHDGACDDTKGBDCCTHGVDVGMSACCHMWGGAGCACTGT Direction: Forward Position #: 2 Overlap #: 12 Alignment: AHRGHCRYKTRBRCCTHGVDVGMSACCHMWGGAGCACTGT -VDGACTRTGGDD--------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Original Motif Reverse Complement AHDGACDDTKGBDCCTHGVDVGMSACCHMWGGAGCACTGT BAGGYCABHBTGACCKHV VAGGWCWBBBKGACCTHVVDVGMSACCHMWGGAGCACTGT Direction: Forward Position #: 1 Overlap #: 18 Alignment: AHDGACDDTKGBDCCTHGVDVGMSACCHMWGGAGCACTGT BAGGYCABHBTGACCKHV---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 6 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mycn Myc Reverse Complement Reverse Complement GCCACGTGSD DCCACGTGCV GCCACGTGSV Direction: Forward Position #: 1 Overlap #: 10 Alignment: GCCACGTGSD DCCACGTGCV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif sscCCCGCGcs Reverse Complement Reverse Complement VSCACGTGGC SBCGCGGGGSB VSCRCGKGGVB Direction: Forward Position #: 1 Overlap #: 10 Alignment: VSCACGTGGC- SBCGCGGGGSB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CTCF Reverse Complement Original Motif BVCCYCGMGSV YDRCCASYAGRKGGCRSYV YBVCCHCGAGVKGGCRSYV Direction: Forward Position #: 2 Overlap #: 11 Alignment: -BVCCYCGMGSV------- YDRCCASYAGRKGGCRSYV ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ssCCCCGCSssk Original Motif Reverse Complement YBVCCHCGAGVKGGCRSYV BBSGGCGGGGBS YBSSSCSGRGVBGGCRSYV Direction: Forward Position #: 1 Overlap #: 12 Alignment: YBVCCHCGAGVKGGCRSYV BBSGGCGGGGBS------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CACTGTGrYrtCACAGTGswsCAcT Reverse Complement Original Motif BMSMGCCBVCMCSGSSSBM CACTGTGRTRTCACAGTGSWSCACT TCACAGTGSWSCACTBASYGYSVBSBMSMGCCBV Direction: Backward Position #: 16 Overlap #: 10 Alignment: BMSMGCCBVCMCSGSSSBM--------------- ---------CACTGTGRTRTCACAGTGSWSCACT ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ESR1 Combined Motif Reverse Complement Reverse Complement VBGGCRSYVSVVSMCMSTBAGTGSWSCACTGTGA MGGTCAGGGTGACCTRDBHV VGGKCASBVBVVCCYVGBBAGTGSWSCACTGTGA Direction: Forward Position #: 1 Overlap #: 20 Alignment: VBGGCRSYVSVVSMCMSTBAGTGSWSCACTGTGA MGGTCAGGGTGACCTRDBHV-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CagTGCTCCACTGTGgT Reverse Complement Reverse Complement TCACAGTGSWSCACTBVCBKGGBVVVBSTGYCCB ABCACAGTGGAGCACTG AYCACAGTGSAGCACTBVCBKGGBVVVBSTGYCCB Direction: Forward Position #: 2 Overlap #: 16 Alignment: -TCACAGTGSWSCACTBVCBKGGBVVVBSTGYCCB ABCACAGTGGAGCACTG------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Reverse Complement Original Motif VGGKCASBVBVVCCYVGBBAGTGCTSCACTGTGMT RGGBCAAAGKYCA RGGGBMARGDBSACCYVGBBAGTGCTSCACTGTGMT Direction: Forward Position #: 2 Overlap #: 12 Alignment: -VGGKCASBVBVVCCYVGBBAGTGCTSCACTGTGMT RGGBCAAAGKYCA----------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif AgTGCTCCACTGTGgTGTCACAgT Reverse Complement Original Motif AYCACAGTGSAGCACTBVCBKGGTSVHCKTYBCCCK AGTGCTCCACTGTGGTGTCACAGT AGTGCWCCACWGTGGWGYMMYRVBBKGGTSVHCKTYBCCCK Direction: Forward Position #: 6 Overlap #: 19 Alignment: -----AYCACAGTGSAGCACTBVCBKGGTSVHCKTYBCCCK AGTGCTCCACTGTGGTGTCACAGT----------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif PPARGRXRA Reverse Complement Original Motif RGGGBMARGDBSACCYVVVKKYRMCWCCACWGTGGWGCACT BTRGGDCARAGGKCA BDRGGBMARRGKBVMCYVVVKKYRMCWCCACWGTGGWGCACT Direction: Forward Position #: 2 Overlap #: 14 Alignment: -RGGGBMARGDBSACCYVVVKKYRMCWCCACWGTGGWGCACT BTRGGDCARAGGKCA--------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ******************************************************* Combined Motifs for Top Global and Local Significant Motif ID 8 and Its Best Matches ****************************************************** ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1st motif name 2nd motif name 1st format 2nd format 1st motif 2nd motif Combined motif ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Myc Mycn Original Motif Original Motif VGCACGTGGH HSCACGTGGC VSCACGTGGC Direction: Backward Position #: 1 Overlap #: 10 Alignment: VGCACGTGGH HSCACGTGGC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif sscCCCGCGcs Original Motif Reverse Complement VSCACGTGGC SBCGCGGGGSB VSCRCGKGGVB Direction: Forward Position #: 1 Overlap #: 10 Alignment: VSCACGTGGC- SBCGCGGGGSB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ssCCCCGCSssk Reverse Complement Original Motif BVCCYCGMGSV SBCCCCGCCSBB SBCCCCGCSSBB Direction: Forward Position #: 1 Overlap #: 11 Alignment: BVCCYCGMGSV- SBCCCCGCCSBB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CTCF Combined Motif Original Motif Reverse Complement SBCCCCGCSSBB BMSMGCCYMCTKSTGGMHM SBYCSCGCCCVCTKSTGGMHM Direction: Forward Position #: 3 Overlap #: 10 Alignment: SBCCCCGCSSBB--------- --BMSMGCCYMCTKSTGGMHM ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CACTGTGrYrtCACAGTGswsCAcT Combined Motif Original Motif Reverse Complement SBYCSCGCCCVCTKSTGGMHM AGTGSWSCACTGTGAMAMCACAGTG SBYMSYGCHSCMYTGTGRMMMCACAGTG Direction: Forward Position #: 4 Overlap #: 18 Alignment: SBYCSCGCCCVCTKSTGGMHM------- ---AGTGSWSCACTGTGAMAMCACAGTG ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif HNF4A Original Motif Reverse Complement SBYMSYGCHSCMYTGTGRMMMCACAGTG TGMYCTTTGBCCK BGVHSTKYVBCCBTGTGRMMMCACAGTG Direction: Forward Position #: 1 Overlap #: 13 Alignment: SBYMSYGCHSCMYTGTGRMMMCACAGTG TGMYCTTTGBCCK--------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR1 Original Motif Original Motif BGVHSTKYVBCCBTGTGRMMMCACAGTG VDBHMAGGTCACCCTGACCY VBBHHVKGTSVCCBTGWSVYMMCACAGTG Direction: Forward Position #: 2 Overlap #: 19 Alignment: -BGVHSTKYVBCCBTGTGRMMMCACAGTG VDBHMAGGTCACCCTGACCY--------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif CagTGCTCCACTGTGgT Reverse Complement Reverse Complement CACTGTGYYKVSWCABGGBSACYBDDBVV ABCACAGTGGAGCACTG ABCACWGTGBAGCVHYRBGGBSACYBDDBVV Direction: Forward Position #: 3 Overlap #: 15 Alignment: --CACTGTGYYKVSWCABGGBSACYBDDBVV ABCACAGTGGAGCACTG-------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif ESR2 Reverse Complement Reverse Complement VBBHHVKGTSVCCBKKDBGCTBCACWGTGBT BAGGYCABHBTGACCKHV VHGBHMDBBBTGMCBKDBGCTBCACWGTGBT Direction: Forward Position #: 1 Overlap #: 18 Alignment: VBBHHVKGTSVCCBKKDBGCTBCACWGTGBT BAGGYCABHBTGACCKHV------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Combined Motif TGGAGCACTGTGACAcCACAGTGg Reverse Complement Original Motif ABCACWGTGBAGCBDYBGYCABVBDRDBCHV TGGAGCACTGTGACAVCACAGTGG TGGASCACTGTGRMRCCACAGTSDBVBDRDBCHV Direction: Forward Position #: 4 Overlap #: 21 Alignment: ---ABCACWGTGBAGCBDYBGYCABVBDRDBCHV TGGAGCACTGTGACAVCACAGTGG---------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Results created by MOTIFSIM on 06-18-2018 13:12:37 Runtime: 641.554 seconds MOTIFSIM is written by Ngoc Tam L. Tran